LONGECITY

Just saw this:

Does Sinclair add Quercitan to his Resveratrol anymore? 

Does Sinclair add Quercitan to his Resveratrol anymore? 

Here is his 2025 stack:

https://brainflow.co...-for-longevity/

 

NMN 

Resveratrol

Vitamin D3

Vitamin K2

Fisetin

Spermidine

Alpha Lipoic Acid

Fish Oil / Omega‑3

Berberine

Nattokinase

Low-Dose Aspirin

Statin

Rapamycin

Metformin

Seems like a pretty good stack to me - pretty close to what most bio-hackers use nowadays.

Looks a good stack to me too .. but strange: metformin and berberine together? really necessary? did not study this in depth though .....

He also has statins, which are not the most healthiest thing to have, seeing as there are better natural and safer alternatives.

Indeed, his stack seems "medication"-heavy.

Which could shorten life.
 

It looks like he is throwing the kitchen sink at it. 

Probably he is seeing deterioration at age 56 and it trying everything he can to halt it.

But with a stack that complicated you are going to have to add one thing at a time, very carefully, get the dose just right, before you add another component. Somehow I don't think he's done that. The time scales are too short. 

More likely he is reading papers, thinking, yeah X has good evidence, I'll add it and just expect to live longer. Then he'll only throw it out if side effects are really overt. 

Yes, that sounds like his strategy. 

And the lack of consistency will probably produce variable results. 

Rapamycin is notably absent.

I am likely recollecting badly but in case wasn't he making a case of low dose antiviral as valacyclovir to reduce impact of herpes infections and dementia risks? If we screen for cardiovascular say w statins and much of the rest for cancer we would progress, right? Maybe Sinclair never touched on this (cannot find why I have thins in mind ...) but curious if you encountered something similar.

This forum is so absurd that someone will select "disagree" to a clearly true statement.

I said "rapamycin is notably absent". Do you see it in his stack? if it's not in his stack, it's absent from his stack. 

This is notable because rapamycin has best support in animal studies as a life extending treatment. 

This forum is so absurd that someone will select "disagree" to a clearly true statement.

 

I said "rapamycin is notably absent". Do you see it in his stack? if it's not in his stack, it's absent from his stack. 

Though I didn't tag with 'disagree', you maybe still oversaw? In the post listing his stack, rapamycin is mentioned as the 2nd last item:
 

Low-Dose Aspirin

Statin

Rapamycin

Metformin

In the first post linked to webpage, one can read more detail:

Rapamycin ~6 mg 4x per year

mTOR inhibitor (Rx)

But I'm not familiar with his former stack. Does anyone know which items changed?

Seems like a pretty good stack to me - pretty close to what most bio-hackers use nowadays.

Though I didn't tag with 'disagree', you maybe still oversaw? In the post listing his stack, rapamycin is mentioned as the 2nd last item:
 

 

In the first post linked to webpage, one can read more detail:

 

 

But I'm not familiar with his former stack. Does anyone know which items changed?

Right, my bad. 

6mg 4x per YEAR??? 

I have been taking 8mg every 9 days. 

Are you taking Rapamycin as a supplement, or for a medical reason?

I’ve been reading about rapamycin. it’s like a “super” anti-aging drug. Basically, it slows down mTOR signaling which seems to be a big reason we age. The way I understand it, evolution only meant this signaling to be active when we’re growing up. After that, it doesn’t really switch off, so it just keeps running. It's like a program on a new PC that you can’t uninstall once the PC is old , and so keeps using up resources and wearing the hard-drive down. Rapamycin slows it down so the body can catch up on repairs.

Rapamycin is an immunosuppressant, taken by transplant recipients to avoid rejection. I assume it come with a whole list of adverse affects. Taking something that takes away your immune system seems counter productive when you are trying to live forever.

Rapamycin is an immunosuppressant, taken by transplant recipients to avoid rejection. I assume it come with a whole list of adverse affects. Taking something that takes away your immune system seems counter productive when you are trying to live forever.

Rapamycin is called an immunosuppressant in transplant medicine, but at the low or intermittent doses studied for anti-aging, it doesn’t weaken the immune system. In fact, it can rejuvenate immunity, improve vaccine responses, and reduce infections in older adults. Serious immunosuppression only happens at the high, chronic doses used in transplants, not at the doses relevant for longevity.

Very interesting, thanks for the information.

Very interesting, thanks for the information.

You're welcome.

In mice, it can boost lifespan by about 3-4 months (roughly 7 human years). But for me, a true longevity substance would extend life by several decades.

So even though rapamycin is the best mTOR modulator we know of, it is not all that great.