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Resveratrol - Micronized?


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#31 maxwatt

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Posted 19 April 2010 - 05:43 PM

Hi Zorba,

Micronization down to 1.5 microns is expensive, reducing the particle size to say... 5-8 microns is not quite as expensive, but we do not consider that particle size as "micronized" since it does not match closely the particle size used at Sirtris, when they compared micronized resveratrol absorption vs non-micronized resveratrol.

We are actually waiting on a new high purity shipment, to begin offering regular non-micronized resveratrol again in bulk form just for folks like yourself and browser who prefer the larger particle (or lower price) of high purity regular bulk resveratrol.

Cheers
A


Do you test for purity after you micronize the power? Grinding can produce heat which can degrade a compound.

Edited by maxwatt, 19 April 2010 - 05:44 PM.


#32 mikeinnaples

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Posted 19 April 2010 - 05:55 PM

Gotta tell my friends that if they want to promote their wares, ImmInst.org is the place to do it.


You have a rather large chip on your shoulder.

Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#33 browser

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Posted 19 April 2010 - 08:56 PM

Gotta tell my friends that if they want to promote their wares, ImmInst.org is the place to do it.


You have a rather large chip on your shoulder.


I can see blatant use of a public forum for advertising. Call it me what you will, this is still, IMO, a violation of the terms of this forum and cheapens ImmInst.org, IMO. One of two reasons I decide /not/ to become a paid subscriber. Why pay to support the advertising of one of the other posters?

Now as far as Sardi's pronouncements to the press, well, I think they're humorous. It's a big mud slinging contest. The thread I started about suppliers cutting their Resveratrol with emodin. Did you notice which self-promoting website the pronouncement came from? All of the mud slinging and self-promotion is setting back our understanding of Resveratrol. Sardi does have one thing right. There's so much hype generated by the 350+ suppliers of Resveratrol that researchers think twice before deciding to do further studies on it.

I /do/ have some problems with the whole idea of taking one's Resveratrol in one fell swoop. Except for dumping Resveratrol on cell models invitro and injecting a Resveratrol solution into various parts of rats, Resveratrol was put in the water or chow. Rats don't get up, eat all of their food then drink all of their water then go on a fast the rest of the night (and in a lab setting, during the day when they wake up). They knosh a lot and sip their water now and again. It's for this reason I am excited about NutriHill's 20 mg. Resveratrol slow dissolving lozenges. May more competition in the area of diverse forms of Resveratrol delivery enter the business and prosper.

#34 Anthony_Loera

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Posted 20 April 2010 - 01:42 AM

Hi Zorba,

Micronization down to 1.5 microns is expensive, reducing the particle size to say... 5-8 microns is not quite as expensive, but we do not consider that particle size as "micronized" since it does not match closely the particle size used at Sirtris, when they compared micronized resveratrol absorption vs non-micronized resveratrol.

We are actually waiting on a new high purity shipment, to begin offering regular non-micronized resveratrol again in bulk form just for folks like yourself and browser who prefer the larger particle (or lower price) of high purity regular bulk resveratrol.

Cheers
A


Do you test for purity after you micronize the power? Grinding can produce heat which can degrade a compound.


Hi Maxwatt.

Our process is proprietary, I can't tell you how it's done. However... I can tell you we tried grinding at one point in china... bad, bad bad... the material suffered and the heavy metals where unacceptable.

A

#35 Anthony_Loera

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Posted 20 April 2010 - 02:37 AM

Browser,

there are certain things I can and I can't say in the forum. Most things I can say revolve around micronized resveratrol, a form of resveratrol that was produced at 1.5 microns on the average. It is not marketing, when you are trying to describe what micronized resveratrol is, and what it does. Comparing Micronized resveratrol particle size, by seeing what Sirtris used is also not marketing. It is information for those that will come here at a later time, looking for answers as to what the heck is meant by "Micronized Resveratrol" whether it comes from one manufacturer or another.

You state that resveratrol lozenges that dissolve slowly are good, while I don't think anything that reduces the time of absorption is good for resveratrol. The point you are trying to make about rats, is pointless in my opinion because you as a human, can metabolize resveratrol very quickly while a rat does not. It is my belief at this time that significant plasma levels in humans cannot be reached with any slow dissolving, or timed release trans-resveratrol substance or product.

The point about resveratrol in ethanol, or micronized resveratrol is to increase absorption and see if a higher plasma levels are achieved immediately, to overcome the issue that your metabolism can quickly remove the 'trans-resveratrol' from your plasma. Because of this, regular resveratrol in a lozenge is not my first choice when it comes to Buccal absorption. Micronized resveratrol or ethanol dissolved resveratrol will certainly work much better for a Buccal application. Tablets and Lozenges are slow, and may have binders and the like, that may not help to produce fast absorption.

As you can see by checking the date I first posted this thread (09/27/2007), we were the first to dive into high absorption resveratrol, and we asked for opinions regarding micronizing resveratrol. We received a lot of feedback, and where the first to produce independently tested micronized resveratrol at 1.5 microns.

Diversity is good, but just because there is a new product on the market, certainly does not mean it is better than everything before it (or less expensive). Heck, we have even produced dry (no ethanol, just pure powder) nano-resveratrol that was measured at less than 50 nanometers by an independent lab. The fact that we can produce something like this which we believe to be the best, can't always be done in mass due to the expense of producing it (or packaging it without creating a large floating nano-resveratrol cloud).

We can create resveratrol gum, resveratrol lozenges, resveratrol drinks, nano-resveratrol powder, resveratrol eyedrops, resveratrol inhalers, resveratrol eardrops, resveratrol based anti-fungal cream, soluble dry resveratrol powder (for tang like) preparations... Oh YEaH! We certainly have the technology, know the people, and understand what it takes... however, what people like you want is not diversity. You simply want something that you believe works for your condition.

In my opinion, we already have the high absorption material people like you are looking for... but you think it is too expensive. It is funny that you believe that: Because a 20mg lozenge with sucralose (http://www.holisticmed.com/splenda/) at $18.95 for 1.2 grams is really pretty high, when you can get 25 grams micronized resveratrol for $75. You have decided to basically pay $15.75 per gram of res in the lozenge, instead of $3 per gram of the pure micronized powder when buying bulk micronized powder.

I have to say, I definitely don't agree with the pricing of your lozenge product, specially because it does not use micronized resveratrol and because it dissolves slowly. Definitely not my personal choice, however if you are happy with it then keep on using it.

Cheers
A

Edited by Anthony_Loera, 20 April 2010 - 02:56 AM.


#36 zorba990

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Posted 20 April 2010 - 02:52 AM

Thanks Anthony, I look forward to when you will have the bulk
non micronized 99% or even 95 back in stock.

Hi Zorba,

Micronization down to 1.5 microns is expensive, reducing the particle size to say... 5-8 microns is not quite as expensive, but we do not consider that particle size as "micronized" since it does not match closely the particle size used at Sirtris, when they compared micronized resveratrol absorption vs non-micronized resveratrol.

We are actually waiting on a new high purity shipment, to begin offering regular non-micronized resveratrol again in bulk form just for folks like yourself and browser who prefer the larger particle (or lower price) of high purity regular bulk resveratrol.

Cheers
A



#37 Anthony_Loera

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Posted 20 April 2010 - 03:13 AM

Thanks Anthony, I look forward to when you will have the bulk
non micronized 99% or even 95 back in stock.

Hi Zorba,

Micronization down to 1.5 microns is expensive, reducing the particle size to say... 5-8 microns is not quite as expensive, but we do not consider that particle size as "micronized" since it does not match closely the particle size used at Sirtris, when they compared micronized resveratrol absorption vs non-micronized resveratrol.

We are actually waiting on a new high purity shipment, to begin offering regular non-micronized resveratrol again in bulk form just for folks like yourself and browser who prefer the larger particle (or lower price) of high purity regular bulk resveratrol.

Cheers
A



I can see it in route to Miami FL, it appears to have stopped in Belgium for the evening according to the airway bill.

It should hopefully arrive and be cleared by customs this week. When it is cleared by the FDA, we will have the batch quarantined and tested by AACL. Once AACL gives us the COA's to confirm quality and purity, we can proceed to use it as needed.

We may have some available within 2-3 weeks because of the lab tests and final packaging.

Cheers
A

Edited by Anthony_Loera, 20 April 2010 - 03:14 AM.


#38 niner

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Posted 20 April 2010 - 03:32 AM

I can see it in route to Miami FL, it appears to have stopped in Belgium for the evening according to the airway bill.

How is it getting around the air travel restrictions? Could it have been stopped in Belgium for longer?

#39 Anthony_Loera

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Posted 20 April 2010 - 03:44 AM

I can see it in route to Miami FL, it appears to have stopped in Belgium for the evening according to the airway bill.

How is it getting around the air travel restrictions? Could it have been stopped in Belgium for longer?



Oh.. that is right, the volcano ash... How the heck did I forget about that?

niner, you may be right ... again! :)

I sure hope things look better for folks trying to get home from overseas.

#40 browser

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Posted 20 April 2010 - 05:44 AM

Browser,

there are certain things I can and I can't say in the forum. Most things I can say revolve around micronized resveratrol, a form of resveratrol that was produced at 1.5 microns on the average. It is not marketing, when you are trying to describe what micronized resveratrol is, and what it does. Comparing Micronized resveratrol particle size, by seeing what Sirtris used is also not marketing. It is information for those that will come here at a later time, looking for answers as to what the heck is meant by "Micronized Resveratrol" whether it comes from one manufacturer or another.

You state that resveratrol lozenges that dissolve slowly are good, while I don't think anything that reduces the time of absorption is good for resveratrol. The point you are trying to make about rats, is pointless in my opinion because you as a human, can metabolize resveratrol very quickly while a rat does not. It is my belief at this time that significant plasma levels in humans cannot be reached with any slow dissolving, or timed release trans-resveratrol substance or product.

The point about resveratrol in ethanol, or micronized resveratrol is to increase absorption and see if a higher plasma levels are achieved immediately, to overcome the issue that your metabolism can quickly remove the 'trans-resveratrol' from your plasma. Because of this, regular resveratrol in a lozenge is not my first choice when it comes to Buccal absorption. Micronized resveratrol or ethanol dissolved resveratrol will certainly work much better for a Buccal application. Tablets and Lozenges are slow, and may have binders and the like, that may not help to produce fast absorption.

As you can see by checking the date I first posted this thread (09/27/2007), we were the first to dive into high absorption resveratrol, and we asked for opinions regarding micronizing resveratrol. We received a lot of feedback, and where the first to produce independently tested micronized resveratrol at 1.5 microns.

Diversity is good, but just because there is a new product on the market, certainly does not mean it is better than everything before it (or less expensive). Heck, we have even produced dry (no ethanol, just pure powder) nano-resveratrol that was measured at less than 50 nanometers by an independent lab. The fact that we can produce something like this which we believe to be the best, can't always be done in mass due to the expense of producing it (or packaging it without creating a large floating nano-resveratrol cloud).

We can create resveratrol gum, resveratrol lozenges, resveratrol drinks, nano-resveratrol powder, resveratrol eyedrops, resveratrol inhalers, resveratrol eardrops, resveratrol based anti-fungal cream, soluble dry resveratrol powder (for tang like) preparations... Oh YEaH! We certainly have the technology, know the people, and understand what it takes... however, what people like you want is not diversity. You simply want something that you believe works for your condition.

In my opinion, we already have the high absorption material people like you are looking for... but you think it is too expensive. It is funny that you believe that: Because a 20mg lozenge with sucralose (http://www.holisticmed.com/splenda/) at $18.95 for 1.2 grams is really pretty high, when you can get 25 grams micronized resveratrol for $75. You have decided to basically pay $15.75 per gram of res in the lozenge, instead of $3 per gram of the pure micronized powder when buying bulk micronized powder.

I have to say, I definitely don't agree with the pricing of your lozenge product, specially because it does not use micronized resveratrol and because it dissolves slowly. Definitely not my personal choice, however if you are happy with it then keep on using it.

Cheers
A


These are 20 mg. Resveratrol per lozenge. I am sure you'd be very happy if I used a whole bottle of your micronized Resveratrol every day. I don't see it necessary. And it is still an assumption that you need a high blood level of Resveratrol else it'll do no good.

I wondered who posted that rant against NutriHill's lozenges, asserting that sucralose is carcinogenic on Amazon. A complete one sided rant. Not unlike your rant about competitors cutting their Resveratrol with emodium. I want diversity because I believe that many of the assumptions about Resveratrol dosing are wrong. You and your sycophants are betting the farm of Sirtris' patent. Like no one ever wrote wrong, erroneous or even purposely misleading information in a patent. Bill Sinclair was so convinced about the usefulness of that patent that he subsequently developed a Resveratrol drink for Shakley.

You and yours are convinced that unless Resveratrol reaches a certain, temporary peak in blood plasma, it's worthless. I'm not of that opinion.

With respect to diversity and what you choose to produce versus what I choose to buy. You were very excited about Resveratrol gum, you were investigating it. Then you suddenly dropped it. Didn't you read the Sirtris patent before becoming excited about the gum?

You keep harping on my condition. That I'm fixing on dying. I'm sure that would be convenient for you. My condition makes me irrational therefore what I say about your endless marketing and stopping at nothing like posting what you did on your website is lashing out and should be ignored. You wish. You're about as off the mark as the guy who keeps pushing his already discredited Propecia cure for prostate cancer.

Very convenient that you are going to add "high quality Resveratrol" once some comes in. Didn't you have this substance to grind up for your more pricey micronized Resveratrol? If I wanted to sell the high premium stuff I certainly wouldn't stock the cheaper stuff. Someone might figure out that if you can get the stuff for a lot less, you can take more and get the same result. Oh, I forgot. It's all explained by the Sirtris patent. How's Glaxco liking their acquisition of Sirtris these days?

#41 Anthony_Loera

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Posted 20 April 2010 - 01:46 PM

Wow, where do I start?

1- The whole point about 'buccal' intake is absorption and a high plasma level in the blood. There is no other reason why you would be taking it, are you now backpeddling?
2- I saw your post on 'cutting resveratrol with emodin' and decided to ignore it, as it is an extract process which takes emodin out (along with other plant phenols and fiber) while making resveratrol higher in purity. Are you are clutching at straws here to try to offend me? I found your assertion in error, and assumed someone else would correct you (which they did).
3- You find it odd that I rely on Sirtris absorption data? While you used to rely on buccal data? (which you then ignore by using a lozenge and paying 5 times more? This makes no sense to me)
4- Sirtris patent data != Resveratrol gum, besides producing the gum would have you paying quite a bit over taking the bulk powder, much like your lozenge.
5- Some of your posts make you seem irrational, I am simply trying to understand why you are all over the map on many things... I can only conclude you are stressed because of your condition and like these boards, as you vent your frustrations in them.
6- We offer 50% resveratrol, 99% resveratrol in capsules, 98% micronized resveratrol powder, 98% micronized in capsules... you certainly don't visit our website to check facts before posting, do you?

We used to offer P98 for a long time:
If you followed the boards here... you would have noticed that we mentioned that we wanted to offer high purity regular resveratrol powder again in April, and it appears we were delayed.

It is as simple as that.

#42 FILY

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Posted 26 July 2010 - 03:41 AM

There is not huge difference between price of resveratrol powder and micronized. The method is not secret. just by special crush machine.
We are the micronized resveratrol manufacturer from China, including resveratrol microcapsule , water- resveratrol and acetyl- resveratrol .
We export 100kg-200kg of micronized resveratrol to USA every month.

#43 mikeinnaples

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Posted 26 July 2010 - 11:47 AM

There is not huge difference between price of resveratrol powder and micronized. The method is not secret. just by special crush machine.
We are the micronized resveratrol manufacturer from China, including resveratrol microcapsule , water- resveratrol and acetyl- resveratrol .
We export 100kg-200kg of micronized resveratrol to USA every month.


Is that with or without heavy metal contaminants or other things that can poison you? Sorry, you are a China supplier, I have to ask.

#44 Anthony_Loera

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Posted 26 July 2010 - 02:38 PM

FILY,

we tried a batch of micronized from china, and it was definitely not as clean (or as small) as the material we produce in the USA. As a matter of fact, we tested it at 5-10 microns with heavy metals. Micronized powder should be around 1.5 microns, not 5-10 microns. Folks considering micronized resveratrol should read the labels to check the particle size. If it's not around 1.5 microns... or doesn't state how large the particles are on the label, then you are victim of marketing if you still purchase it. :blink:

A

Edited by Anthony_Loera, 26 July 2010 - 07:36 PM.

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#45 2tender

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Posted 26 July 2010 - 02:44 PM

Regarding this, I only purchase Resveratrol from an American company that has third party testing done on all batches. Right now there is only one that I would purchase from. China has a bad reputation right now for Resveratrol. COA's from an American tester are mandatory.

#46 FILY

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Posted 27 July 2010 - 01:39 AM

FILY,

we tried a batch of micronized from china, and it was definitely not as clean (or as small) as the material we produce in the USA. As a matter of fact, we tested it at 5-10 microns with heavy metals. Micronized powder should be around 1.5 microns, not 5-10 microns. Folks considering micronized resveratrol should read the labels to check the particle size. If it's not around 1.5 microns... or doesn't state how large the particles are on the label, then you are victim of marketing if you still purchase it. :blink:

A


Particle size distribution: 100% < 5 microns, 20%< 1.5 microns. It meets customer's requirment. And that is what can do.
As to heavy metal, Customer from USA told me it is ok.

#47 FILY

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Posted 27 July 2010 - 01:44 AM

Regarding this, I only purchase Resveratrol from an American company that has third party testing done on all batches. Right now there is only one that I would purchase from. China has a bad reputation right now for Resveratrol. COA's from an American tester are mandatory.


2 tender

Maybe you are right, there are so many resveratrol suppliers from China, But not all of suppliers as you described. :)

#48 Anthony_Loera

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Posted 27 July 2010 - 01:46 AM

Particle size distribution: 100% < 5 microns, 20%< 1.5 microns. It meets customer's requirment. And that is what can do.
As to heavy metal, Customer from USA told me it is ok.



Particle size on a D50 scale should be 1.5 microns, 20% doesn't cut it for us. However to verify your production and safety, I have two questions for you that may help all of us:

1- What are the PPM for heavy metals.
2- To verify your company and micronization production, who is your customer in the USA so that we may contact them as a reference and confirm the order?

Thanks
A

P.S. Kind of surprised maxwatt has allowed this thread to continue.

Edited by Anthony_Loera, 27 July 2010 - 01:57 AM.


#49 FILY

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Posted 27 July 2010 - 01:47 AM

There is not huge difference between price of resveratrol powder and micronized. The method is not secret. just by special crush machine.
We are the micronized resveratrol manufacturer from China, including resveratrol microcapsule , water- resveratrol and acetyl- resveratrol .
We export 100kg-200kg of micronized resveratrol to USA every month.


Is that with or without heavy metal contaminants or other things that can poison you? Sorry, you are a China supplier, I have to ask.


mikeinnaples

We sent sample to our customer and have a third party test. It is ok.

#50 maxwatt

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Posted 27 July 2010 - 02:02 AM

There is not huge difference between price of resveratrol powder and micronized. The method is not secret. just by special crush machine.
We are the micronized resveratrol manufacturer from China, including resveratrol microcapsule , water- resveratrol and acetyl- resveratrol .
We export 100kg-200kg of micronized resveratrol to USA every month.


Is that with or without heavy metal contaminants or other things that can poison you? Sorry, you are a China supplier, I have to ask.


mikeinnaples

We sent sample to our customer and have a third party test. It is ok.


One problem with grinding (special crush machine?) to micronize resveratrol is that it generates heat, which can decompose resveratrol int other, unknown compounds whose effects are uncertain. This would not necessarily show up on a cursory assay, depending on the test methods used and the concentration of heat-generated impurities.

I am curious what methods Anthony, or FILY, use to control heat decomposition when grinding resveratrol.

#51 Anthony_Loera

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Posted 27 July 2010 - 02:15 AM

Hi Maxwatt,

I guess you are letting this thread continue. Not a problem, I can certainly post a quick advertisement to sell bulk micronized resveratrol if others are ok to do so:

<Blatant Advertisement>
=========================================================
:-D Buy Micronized Resveratrol from us, why? :-D

We micronize it here in the USA in an FDA facility using cGMP processes rather than outside of the country where the FDA has no reach. We also do not import our raw materials from China for our Micronized Resveratrol!

Just IM me if you want wholesale prices! :laugh:
=========================================================
</Blatant Advertisement>

Ok, enough of the fun stuff. Our process is proprietary, so I am limited to what I can say. What I can say, is that our Licap product, and 500mg micronized capsules and I believe our bulk powder all have a COA's that you can check.

Cheers, and thanks for allowing blatant advertising on this thread.
A

Edited by Anthony_Loera, 27 July 2010 - 02:19 AM.


#52 FILY

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Posted 27 July 2010 - 02:58 AM


Particle size distribution: 100% < 5 microns, 20%< 1.5 microns. It meets customer's requirment. And that is what can do.
As to heavy metal, Customer from USA told me it is ok.



Particle size on a D50 scale should be 1.5 microns, 20% doesn't cut it for us. However to verify your production and safety, I have two questions for you that may help all of us:

1- What are the PPM for heavy metals.
2- To verify your company and micronization production, who is your customer in the USA so that we may contact them as a reference and confirm the order?

Thanks
A

P.S. Kind of surprised maxwatt has allowed this thread to continue.

That is the least particle size we can get by traditional crush method for resveratrol physical property. I think it is more expensive to obtain 1.5 microns powder(nanometer grinder or other).
Heavy metals meets USP standard.
I am sorry I can't tell you my customer's name in USA. We should respect them. :)

#53 FILY

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Posted 27 July 2010 - 03:01 AM

There is not huge difference between price of resveratrol powder and micronized. The method is not secret. just by special crush machine.
We are the micronized resveratrol manufacturer from China, including resveratrol microcapsule , water- resveratrol and acetyl- resveratrol .
We export 100kg-200kg of micronized resveratrol to USA every month.


Is that with or without heavy metal contaminants or other things that can poison you? Sorry, you are a China supplier, I have to ask.


mikeinnaples

We sent sample to our customer and have a third party test. It is ok.


One problem with grinding (special crush machine?) to micronize resveratrol is that it generates heat, which can decompose resveratrol int other, unknown compounds whose effects are uncertain. This would not necessarily show up on a cursory assay, depending on the test methods used and the concentration of heat-generated impurities.

I am curious what methods Anthony, or FILY, use to control heat decomposition when grinding resveratrol.

The temperature keeps under 40℃ during prcessing less than 5min.

#54 Anthony_Loera

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Posted 27 July 2010 - 04:10 AM

That is the least particle size we can get by traditional crush method for resveratrol physical property. I think it is more expensive to obtain 1.5 microns powder(nanometer grinder or other).
Heavy metals meets USP standard.


The 'traditional method' of grinding usually is not very effective to create single micron materials, so I can now understand why you cannot achieve 1.5 microns, and why you probably have a PPM of 20 or higher for heavy metals.

I am sorry I can't tell you my customer's name in USA. We should respect them.


If your company is not a known supplier of resveratrol, I don't think many people would do business with you without references.

#55 niner

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Posted 27 July 2010 - 06:09 AM

I am sorry I can't tell you my customer's name in USA. We should respect them.

If your company is not a known supplier of resveratrol, I don't think many people would do business with you without references.

A public forum isn't really the place to be naming customers, unless the customer has specifically OK'd it.

#56 maxwatt

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Posted 27 July 2010 - 11:03 AM

FILY is not blatantly advertising. Though he is publicizing his company's abilities, is is providing potentially useful information.

Most of the resveratrol extractors are located in Hunan or adjoining provinces. FILY identifies himself as from Shanghai. I believe he is then either associated with a certain pharmaceutical company, or is or is working for a trader.

In any case, I am not convinced of the necessity of using a micronized product to obtain good results from resveratrol. It does aid in using a dispersant, which does obtain a higher peak serum level than with a similar, non-micronized dose. However, teh area under the curve (AUC) remains the same either way, and using a higher dose of non-micronized powder could achieve the same results. I do not think this applies to just filling a capsule with resveratrol powder. Some simple tests I've done indicate to me that with a capsule, pure resveratrol powder tends to clump on dissolution of the capsule, and much of it can then pass through the gut and be excreted without being absorbed. (This is something that at this point I classify as a reasonable speculation.) I believe those who favor buccal or sublingual administration are on to something, not so much because of improved absorption through the mucosa, but because eld in the cheek or under the tongue, resveratrol slowly disperses and is swallowed with the saliva (or with a glass of water) which effectively disperses it for better absorption.

#57 FILY

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Posted 27 July 2010 - 11:56 AM

FILY is not blatantly advertising. Though he is publicizing his company's abilities, is is providing potentially useful information.

Most of the resveratrol extractors are located in Hunan or adjoining provinces. FILY identifies himself as from Shanghai. I believe he is then either associated with a certain pharmaceutical company, or is or is working for a trader.

In any case, I am not convinced of the necessity of using a micronized product to obtain good results from resveratrol. It does aid in using a dispersant, which does obtain a higher peak serum level than with a similar, non-micronized dose. However, teh area under the curve (AUC) remains the same either way, and using a higher dose of non-micronized powder could achieve the same results. I do not think this applies to just filling a capsule with resveratrol powder. Some simple tests I've done indicate to me that with a capsule, pure resveratrol powder tends to clump on dissolution of the capsule, and much of it can then pass through the gut and be excreted without being absorbed. (This is something that at this point I classify as a reasonable speculation.) I believe those who favor buccal or sublingual administration are on to something, not so much because of improved absorption through the mucosa, but because eld in the cheek or under the tongue, resveratrol slowly disperses and is swallowed with the saliva (or with a glass of water) which effectively disperses it for better absorption.


maxwatt

It seems that you are Old China Hands , and know china plant extract industry very well. The wild herb Polygonum cuspidatum main distribute in Hunan province, so manufacturers loacted in that province and shanxi provice which is near to Hunan. I do not want to say more things about my company, but we have a factory in shandong provice.

You can buy resveratrol easily in China, even in very low price. what we focus is Resveratrol-related products.(resveratrol micronized, water-soluble resveratrol, acetyl-resveratrol and resveratrol microcapsule). most of China resveratrol suppliers just care about resveratrol.

As to improve bioavailability by high-dose resveratrol. maybe you can find something from this research paper.

The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol.
You can download from attachment.
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#58 Anthony_Loera

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Posted 27 July 2010 - 12:15 PM

Maxwatt,

dry micronized resveratrol will be less effective than micronized resveratrol in an emulsion, that is the reason why tween 80 in a licap is used. However purists will prefer the powder in a vegetarian capsule without an emulsion.

Having said that I share similar views regarding your other statements. I continue to agree that a dispersant or emulsion using resveratrol would be best, for absorption rather than just dry powder.

Cheers
A

Edited by Anthony_Loera, 27 July 2010 - 12:17 PM.


#59 LongLiveMom

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Posted 09 August 2010 - 07:58 AM

Life-enhancement have a very bad reputation from what I have seen and heard. Have a look at their product over at consumerlabs



I read about that report, too...thank God for the likes of consumer labs!

Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#60 mikeinnaples

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Posted 09 August 2010 - 12:44 PM

Life-enhancement have a very bad reputation from what I have seen and heard. Have a look at their product over at consumerlabs



I read about that report, too...thank God for the likes of consumer labs!


1. God doesnt exist.

2. Consumer Labs is far far far from an impartial source.
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