8 replies to this topic

[Anthony_Loera]

The article was brought to my attention by a user on the [GRG]
I am not sure if this has been presented here before.


It is quite interesting, and I think may be something folks here would like to read about.
http://discovermagaz...n-we-cure-aging

Thanks
Anthony

[Live Forever]

Oooh, interesting. I always love to see these types of articles. Thanks for the link. :thumb:

[Mind]

The caveat with these experiments is that by modifying inflammation, we are playing with fire. After all, fighting off infection is an absolutely essential bodily function. “The danger of monkeying around in a system like that is that you may do more harm than good,” Cohen says. But humans appear willing to renegotiate the ancient evolutionary bargain that traded robust reproductive health for frail old age.

I tend to think that with our knowledge and monitoring of infectious disease we could selectively suppress or increase inflammation when needed.

[forever freedom]

So living in an isolation bubble does help to extend a lifespan after all.


Think about living in an isolation bubble + doing CR.... maybe it would give us an considerable amount of years? But then again, who would want to live in a bubble? =/

[caston]

So living in an isolation bubble does help to extend a lifespan after all.

Are these any studies on this? Is it even possible to raise an organism in an environment with no competing bactera, pathogens, virus's, fungii, and prions?

Edited by caston, 07 December 2007 - 12:17 AM.

[Anthony_Loera]

So living in an isolation bubble does help to extend a lifespan after all.

Are these any studies on this? Is it even possible to raise an organism in an environment with no competing bactera, pathogens, virus's, fungii, and prions?

I haven't seen any studies like this at all.

It does (for some unknown reason...) remind me of an episode of (yes, I it's ridiculous I know...but I can't stop typing...it..)
Star Trek:

"Pulaski suddenly remembers the "Thelusian Flu" aboard the Lantree and asks how the children's immune systems would react to it. Kingsley says it would be genetically altered to extinction. Pulaski believes that's what happening to them — the children's immune systems are attacking everyone." -Unnatural Selection episode.

(Ugh, I Digressed horribly...)

I think folks living with HIV can probably be considered the folks who most likely would continue to live in a bubble, but I don't notice many who actually do completely cut themselves off physically, even if they would live longer. I don't think regular folks would choose this unless you could create a closed in colony of some sort.

I suppose people would have to choose the bubble, or a regular limited life.
If you could live in a bubble, would you want to?

A

[missminni]

One of the caveats with blocking the protein in nf-kappa B, (which resveratrol blocks), which I believe
is what stops inflammation/aging, is that if it is blocked too much, the skin cells might proliferate to
a degree that could be cancerous. I believe that was a possibility mentioned by Dr. Chang in one of
the articles I read. Not that this would deter me, vain risk taker that I am, but it is something to consider beside being more vulnerable
to infections. I found the excerpt from the article below:

link to article Chang and Adler caution that their findings aren't likely to be the source of the long-sought fountain of youth. That's because they don't know if the rejuvenating effects of NF-kappa-B are long-lasting. Also, the protein has roles in cancer, the immune system and a range of other functions throughout the body. Suppressing the protein on a long-term basis could very well result in cancers or other diseases that undermine its otherwise youthful effect.

"You might get a longer lifespan but at the expense of something else," Chang said.

[Mind]

Just another paper on inflammation and aging, this one related to the function of microglial cells.

and another forum discussion about inflammation and skin aging.

[Luna]

Umm, yay for LYSO-SENS