3 replies to this topic

[treonsverdery]

about 2/3 of developed world people during the 20th century died from heart disease
atherosclerosis is a big aspect of this

this paper http://www.lipidworl.../content/6/1/32 describes an immunization effective against atherosclerosis; mosshed TB bacteria plus low density lipoproteins protects rabbits

curiously mooshed TB bacteria known as freunds adjuvant are published as effective at reducing athersclerosis progression

this has been on the radar since the mid nineties, a primate study would obviously be of great value

curiously for you diabetes drug causes longevity people Freund's adjuvant is also published as blocking the start of diabetes among lab mice http://en.wikipedia....eund's_adjuvant

If any of you physician advised medically aware people have the urge I'd consider weighing the benefits of having the dangerous uncomfortable Freund's adjuvant treatment overseas

[lucid]

Paper:

Results
Immunization with Cu -LDL and MDA-LDL induced statistically significant antibodies against ox-LDL. In hypercholesterolemic rabbits immunized with MDA-LDL the level of cholesterol, LDL-cholesterol, triglyceride, fasting blood sugar and fatty streak lesions in aorta and right coronary arteries were significantly decreased as compared with non-immunized high-cholesterol group. Immunization with Cu -LDL in hypercholesterolemic rabbits significantly decreased triglyceride, fasting blood sugar, cholesterol and CRP. No significant differences were detected in the fatty streak lesions in this group as compared with non-immunized high-cholesterol diet. In groups under normal diet immunized with MDA-LDL or Cu -LDL no significant effect on biochemical factors and atherosclerotic lesions were observed.


Conclusions
This study indicates that although the effect of produced antibodies in several methods and different dietary regimens is different, immunization against ox-LDL is antiatherogenic.

Very interesting. Reading this makes me wonder why no one had tried this before. Seems very simple and straight forward, not to mention very cheap.

[treonsverdery]

1: Curr Opin Mol Ther. 2007 Apr;9(2):176-82.Links
Active and passive immunization for atherosclerosis.Chyu KY, Nilsson J, Shah PK. http://www.ncbi.nlm....Pubmed_RVDocSum
Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Division of Cardiology and Atherosclerosis Research Center, Suite 5347, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Inmmunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.

Vaccines for cholesterol management.Rittershaus CW.
AVANT Immunotherapeutics Inc., 119 Fourth Ave., Needham, Massachusetts 02494, USA. crittershaus@avantimmune.com

Over the last 50 years, several attempts have been made to harness the power and economy of vaccines in the fight against cardiovascular disease. Vaccines directed to lipoproteins, cholesterol itself, and molecules involved in cholesterol metabolism have all demonstrated success in modifying progression of disease in animal models of atherosclerosis. One vaccine that elicits antibodies to cholesteryl ester transfer protein has also progressed into the realm of human clinical testing . This review summarizes the published scientific work describing the various approaches that have been tried, their strengths and weaknesses, and where this field may go in the future.

Edited by treonsverdery, 24 January 2008 - 04:41 AM.

[treonsverdery]

Item

Edited by treonsverdery, 31 January 2008 - 08:56 AM.