upregulate the CYP3A4 liver enzymes that scrub all steroids as well as cholesterol from the blood; measure the effect on atherosclerosis as well as cardiac related death
The herb St johns wort raises CYP3A4 2/5
the cerebroprotective ischemia drug and discussed nootropic phenytoin raises CYP3A4
perhaps this will have effects like statins that reduce cholesterol as well as cardiac related deaths
Now here's the idea:
either of these materials are predicted to reduce cholesterol, atherosclerosis as well as cardiac related deaths
Amazingly there are zero papers at pubmed.org with search items [atherosclerosis, CYP3A4] or [cardiac, CYP3A4] that talk about how the amount of this liver enzyme affects atherosclerosis or heart disease; it's like researchers were studying "the kitchen sink" dids lots of research on faucets n sponges but did zero research on the size of the drain, or the effect of a bigger drain
update:
there is a review article that describes this idea at http://www.ncbi.nlm....Pubmed_RVDocSum Several compounds induce P450 and other genes regulating cholesterol balance and prevent or regress atherosclerosis
funny: prior to finding the review article I thought that if a person want to write a great med school app or do something that rapidly confers full professor status it would be studying if more liver CYP3A4 means less heart disease; I think it went well with the reviewer
there is a powerful idea that goes with the proven validity of the upregulation of liver enzymes to prevent or regress atherosclerosis
any immunization that creates immune response to the body's CYP3A4 minimizers may amplify CYP3A4 creating less atherosclerosis; a heart disease vaccine
Edited by treonsverdery, 23 January 2008 - 07:22 PM.
