Need help updating My Regime after this post...but I wanted first to review my illnesses and also the state of Research Understanding and Pipeline Treatment for Autoimmunity.
WARNING A LONGGGGGGGGGGGG POST !?
Well Ive got at a few things going on so to speak...Sjogrens type symptoms, Parietal Cell Antobodies, Hashimoto's, Arthritis (AS & HLA-B27+)
and also unexplained Hepatitis of unknown etiology.(personally I think it is Seronegative -Primary Biliary Cirrhosis)
I also have Neuropathies, twitching, spams, numbness, pain allover..starting to lose fine motor in right hand (cramps on release of objects)...
So perhaps CNS but also perhaps Peripheral issues.
Important to note for everyone...some of these diagnosis are confirmed thru bloods (antibodies seen) but others like the Neuropathy, Sjogrens, and Hepatitis have no reason to be there according to the current diagnostics !!!!!!!
And believe me Ive had them all...(cept a Lyme Test)
So if you ever get sick and they cant find out why... don't be surprised.
They just dont have tests that are either 100% or cover every variation.
Autoimmunity 100+ diseases and counting:
it is in my opinion one of the most contentious issues of our time...so the immune system with seemingly unending signaling complexities.
Put immunology Researchers into a room and see them all disagree.
Even how or what is Autoimmunity...basic questions unanswered..even with the best computer models..still no answers.
What I can vouch for is...genetics...your family is what makes you... their genetics mixed together is what you end up with...it is now proven that twins DO get AI diseases...sometimes takes 30 years longer for the other twin to get sick but they do eventually... and sets of genes makes you more likely to get these diseases.
Now what actually triggers the diseases into being is another thing...for me it was a set of Pathogens.... 'Camplyobacter Jeujuni' and then closely followed by severe 'Zoster Virus'...something changed....shifted in my state...transcribing into disease symptoms.
Now 'Trev' Marshall of 'MP' fame talks about pathogens getting into cells..so small no one can see them as the cause for this switch on of TH1 sustained response...
the question for me is ...are the pathogens still in me causing my immune system to attack itself...or are they gone?...more questions...
Did they either look like my genes for instance (HLA-B27+) while they were there confusing the immune system into a permanent state of Autoimmunity..or did the pathogens while they were there switch on some genes that look like pathogens to the immune system memory.....or did genetic manipulation by these viruses cause the immune system to be confused...or is it simply that the immune system is aging and its assembly line gets a bit rusty, turning out faulty immune cells...
...or as 'Marshall' reckons they invaded our cells...so many different ideas...yet none have been proven/disproven..
Perhaps a clue..
Resetting the Immune system (blowing it away with drugs) repopulating with Stem Cells...growing a new Immune system has had some success...however it is not 100%...remission of partial symptoms is to me puzzling
This suggests to me that perhaps either the pathogen is still in you...or well what else could it be...my immunologist says that its because ones genes are still the same after resetting the immune system..but I dont buy it..so what if they are.
I was not born with these diseases..only started 3 years ago...after Pathogens attacked me..soooo....once reset you should be right if you can avoid the Pathogen/Environmental triggers for another 40 years say..
as the new Immune system grows it should recognise the state it grows in as OK not pathogen...yet some who have this ultimate treatment do not benefit as much as they should in theory...why ?
So perhaps the Pathogens are still in you and are popping their heads out of cells or mutating to look slightly different yet close enough to our own cells...in this way it sounds like Im saying Marshall could be right ....it would have to be a pathogen that is active..
Or perhaps as we age and the process of Autoimmunity begins it sets of a cascade of constant gene changes...that the immune system cannot get a stable fix on...
Autoimmune Therapies:
Current:
B-Cell Depletion, DMARD's...obliterate most of the immune system...like using Agent Orange to stop weeds in your garden..it works but kills most everything else around....in short current therapies are few...and cause many other symptoms...and in some are the cause of death.
If you didnt know...there has never ever been a treatment that has cured one Autoimmune Patient of any Autoimmune Disease...period ! Remission is as close as they have got...the process is still there.
btw this includes the 'Marshall Protocol'
New Ideas:
Some new therapy directions are to try and selectively rebalance the TH1 to a more balanced immune system ... imbetween TH1 & TH2 by increasing/inducing T-regulatory cells.
In inflamed tissue...biopsies reveal a cluster of T-regulatory cells..so the immune system is trying to do its job at regulating but something is making them ineffective..
having these clusters of T-reg cells is part of the reason why Autoimmune Diseased people are many more times more likely to get cancer in those inflamed organs.
Then they talk about effective and non effective (or defective) T-Regulatory cells. perhaps the Autoimmune diseased patient has now ineffective T-regs to this particular TH1 issue..unable to stop the sustained inflammation after the pathogen has gone...perhaps the older we get the less effective they can become...perhaps again genetics..perhaps something has changed with the creation of T-regs...the assembly line has faults.
It is now documented that the fetus uses T-regs at least partially to avoid immune wars with mum...this link below especially interesting regarding the begnnings of our own immune development for autoimmunity
http://www.punchng.c...t20081214444917Thus the T-Reg therapy camps are looking at ways of inducing effective T-reg's
either as a master immune volume control..or more specific targets.
"dnaJP1"
http://www.tucsoncit...tpage/77417.php or specific Antigen targeted created crafted T-regs...
such as MultiVax
http://www.fiercebio...oney/2008-12-09Other Options
Another known has 'Tranilast'
N-(3',4'-dimethoxycinnamonyl) anthranilic acid...its exact action is not known...its a synthetic Metabolite from Tryptophan.
http://www.nuonthera..._sclerosis.htmlNow there are others ..but that this is the limit of my research so far..
So if anyones got some direction for new therapies which Ive missed please let me know !?
HomeBrew Inducement of T-regs;
Well a lot of people already take Probiotics...aka yoghurt..
Some of the strains have been found to induce T-regs...Bifodus infantis...as well Lactobacillus Reuteri...and some other strains....no one really knows what interactions do take place between the zillions of Bacteria and strains in the gut though.
UVB Induces Tregs..but of course also skin cancer.
DHEA Metabolite induces T-regs...but also of course other effects.
Tryptophan Metabolite induces T-Regs.(Tranilast)
Statins - Induce T-regs and some nasty side effects as well
Parasites...helminths induce T-regs (worms)
CAFFEINE
btw i mentioned earlier in this thread that Caffeine induces T-regs but it does NOT..in fact it suppresses T-reg activity...paradoxically it reduces TNF-Alpha.
I have missed some treatments i know...let me know please to add to the list.