37 replies to this topic

[Shepard]

What is the major arguments that Cr wouldn't work in humans as well as in mice?

Here is a thread that has links and references to plenty of reading material:

http://www.imminst.o...Lloyd Demetrius

Edited by shepard, 11 May 2008 - 07:00 PM.

[VictorBjoerk]

Does anyone know how the Rhesus Apes are doing with Richard Weindruch?Have the Cr monkeys started getting old and dying off yet?

[Matt]

They have better survival, zero diabetes, less cancer, less arthritis and other complications... They have sharper minds, and also better immunity than ad lib fed group. They also look a lot younger according to the care takers of the monkeys.

Edited by Matt, 13 May 2008 - 01:16 AM.

[maestro949]

Which are all secondary aging markers - mostly those that lead to disease and death well before maximum lifespan is reached. Primary damage is still occurring (ROS, (epi)genetic damage, stem cell decline, amyloid buildups, etc). Even if primary damage is occurring at a slower rate with CR, which appears to be the case, longer lived species will likely show a less significant gain in maximum lifespan than their shorter-lived calorie restricted counterparts simply because there is more time for damage types less affected or unaffected by CR to exponentially accumulate and compound.

Edited by maestro949, 13 May 2008 - 10:17 AM.

[VictorBjoerk]

But this build-ups of proteins and damage may occur faster in mice although their short lifespan just like in the children with progeria,or?
Have any of the monkeys started dying from old age?

[Matt]

But this build-ups of proteins and damage may occur faster in mice although their short lifespan just like in the children with progeria,or?
Have any of the monkeys started dying from old age?

One of the groups, the group put on CR since 1989 are starting to die off yes. Monkeys were then introduced in 1994 so they will die off a little later.

The oldest 'rhesus monkey' on record is apparently C58 the one in the Calorie Restricted group at the NIA. He died at 43 (which around 129 human years).

[maestro949]

But this build-ups of proteins and damage may occur faster in mice although their short lifespan just like in the children with progeria,or?

Mice have fewer damage repair pathways than higher mammals so yes, they accumulate damage faster. When taken out of the wild, they tend to die of cancer as many cellular damage types lead to cancer. Progerias are genetic defects that lead to usually lead to heart disease.

Have any of the monkeys started dying from old age?

Not sure but it's still too early to fully assess the impact on maximum age. There are 3 tests going on; The NIA study, the U. Wisconsin study and the U. of Maryland study. All started > 1987 and max lifespan is ~25 so we have at least a few years to go I would think.

Edited by maestro949, 13 May 2008 - 11:40 AM.

[VictorBjoerk]

But this build-ups of proteins and damage may occur faster in mice although their short lifespan just like in the children with progeria,or?
Have any of the monkeys started dying from old age?

One of the groups, the group put on CR since 1989 are starting to die off yes. Monkeys were then introduced in 1994 so they will die off a little later.

The oldest 'rhesus monkey' on record is apparently C58 the one in the Calorie Restricted group at the NIA. He died at 43 (which around 129 human years).

Isn't he the oldest recorded rhesus monkey ever?