Yes this is an obvious one, CR obviously protects from skin aging as we can see from the animal evidence in CR rodents, dogs, and monkeys. Some people on CR tend to look younger than their ages too. I had this study in my folder for a little while but never got around to reading it until now, so thought you might be interested:
PDF:
Modulation of Cutaneous Aging With Calorie
Restriction in Fischer 344 Rats
http://archfaci.ama-.../reprint/7/1/12
Objective: To examine whether histological changes in
skin owing to intrinsic aging in a laboratory rodent model
are modulated by caloric restriction (CR).
Methods: The abdominal skin from colony-raised ad libitum–
fed Fischer 344 rats and age-matched rats subjected
to CR was studied in the light microscope using
histological morphometric methods. Animals 4, 12, and
24 months or older were used in this study. We studied
the skin to obtain (1) quantitative data on the depth of
the epidermis, dermis, and fat layer, the epidermal cellular
density, the percentage fraction of dermal collagen,
elastic fibers, pilosebaceous units, and capillaries,
and the fibroblast density; and (2) qualitative assessment
of histological staining for dermal glycosaminoglycans.
We analyzed data by means of general linear model
2-way analysis of variance to obtain significance for the
effects of age, diet, and age-diet interaction.
Results: The ad libitum–fed rats showed age-related increase
in the depth of the epidermis, dermis, and fat layer.
Calorie restriction prevented these changes, but epidermal
nuclear density appeared to be stimulated. A trend
toward increased values for collagen and elastic fibers,
fibroblasts, and capillaries in skin samples from CR rats
was observed. Pilosebaceous units were not modified.
Moderately reduced staining for the dermal glycosaminoglycans
in the skin of CR rats was noticed.
Conclusions: Histomorphological changes resulting from
intrinsic aging affected some of the studied variables in the
rat skin, and these changes were delayed or prevented by
CR. Some stimulatory effects, such as increased densities
of fibroblasts and capillary profiles and higher values of
connective tissue fibers resulting from CR, were also observed.
Cutaneous morphological changes due to natural
aging in this rat model seem to be modified by physiological
or metabolic alterations imposed by CR.
Edited by Matt, 11 June 2008 - 05:36 PM.
