As much as I am informed sceletium (more precisely active alkaloid mesembrine) has been scientifically confirmed to posess serotonin reuptake activity and to be a selective phospodiesterase-4 inhibitor. However there are claims it also taps into dopaminergic and cholinergic pathways, but for these two I haven't found any confirmation, so those claims might just as well be "guesses".
I've been reading about user experiences of its similarity to a low dose MDMA which led me to compare mesembrine's molecular structure to that of MDMA's. Overall they aren't certainly identical, but there are some interesting similarities. Sceletium isn't hallucinogenic, whereas MDMA is.
Anyone more informed on sceletium's alkaloid pharmacology? What effects did it have for you, how would you compare them to other psychoactive compounds?
Edited by ikaros, 02 July 2008 - 04:53 PM.