I kept looking, From the provided link - Ray Peat writes-
The most popular way of arguing that fish oil will prevent heart disease is to show that it lowers blood lipids, continuing the old approach of the American Heart Association's "heart protective diet." Unfortunately for that argument, it's now known that the triglycerides in the blood are decreased because of the fish oil's toxic effects on the liver (Hagve and Christophersen, 1988; Ritskes-Hoitinga, et al., 1998). In experiments with rats, EPA and DHA lowered blood lipids only when given to rats that had been fed, in which case the fats were incorporated into tissues, and suppressed mitochondrial respiration (Osmundsen, et al., 1998).
I researched this to find that here is what Hagve says in the
abstract -
The finding that n-3 fatty acids are transported from the liver as ketone bodies to a larger extent than n-6 fatty acids may thus explain that a high intake of n-3 fatty acids is not accompanied with hepatic steatosis. (fatty liver)
On this
link I found someone else who had been asked about Ray Peat's ideas, so he researched three of Ray Peat's assertions. One of them was the same one where I was finally able to find a reference source. This blogger fact checked three assertions in a row, and Ray Peat missed every one of them. This investigation is proving good to me, because I am examining my commitment to fish oil. And I have found one thing I am not certain of. Hemorrhagic stroke. I am controlling nose bleeds with K1, and my clotting time has been checked by the Red Cross. But, maybe, my clotting is not within a healthy range. My last surgeon didn't care whether or how much fish oil I take. So I have an array of facts that made me comfortable. But now I intend to get my clotting measured and make sure that I am in the safe zone. That is the same procedure used to make coumadin safe.
From the BlogMisty,
re Ray Peat's ideas, particularly trying to see what is what in the text you mention:
I have a number of problems with this document. The first is that the references in the text are in the format (Author/s year). In the reference section they are listed alphabetically by the title of the journal in which they appeared. This makes following them a nightmare.
I checked up on three of them, hitting fairly at random on those supporting this section which purports that fish oil is toxic to the liver:
"Unfortunately for that argument, it's now known that the triglycerides in the blood are decreased because of the fish oil's toxic effects on the liver (Hagve and Christophersen, 1988; Ritskes-Hoitinga, et al., 1998). In experiments with rats, EPA and DHA lowered blood lipids only when given to rats that had been fed, in which case the fats were incorporated into tissues, and suppressed mitochondrial respiration (Osmundsen, et al., 1998)."
Hagve and Christophersen, 1988
This one actually says they encourage ketogenesis and stop hepatic steatosis (fatty liver). Sounds OK to me.
Ritskes-Hoitinga, et al., 1998
This one fed rabbits 40% of calories as fat and up to 20% of calories as fish oil. Rabbits eat grass.
Osmundsen et al 1998
As far as I can make out this last paper is looking at the metabolism features of omega 3 fatty acids, which are clearly specific to omega three fatty acids, and different from other fatty acids. I'm happy with that. I don't see any mention of toxicity. This paper is available full text and I've been through the introduction and discussion. These discuss metabolism without mentioning toxicity. There are undoubted differences in fatty acid metabolism between different fats. So be it. Toxicity??? I'm not convinced.
Too much of a slog to go through the whole document. My take on Alzheimers is that it is carbohydrate poisoning. Re BSE, the prion hypothesis is absolutely that, hypothesis. Researches in this field who give small group seminars to the scientists, my wife included, at her institute are VERY careful to stress that the prion hypothesis is not remotely proven. Not what you would think from the BBC reports, or DEFRA. The cause of BSE is currently unknown.
Grass has omega 3 fats, cows put omega three fats to their muscles. I eat those muscles. This sort of "bovine" level seems fine to me. A few grams extra to compensate for grain feeding to beef also seems fine. I'd not go for 30ml a day from a bottle of cod liver oil myself, but I worry that Peat goes over the top. I would agree that anyone getting 20% of their calories from flax oil is in trouble!
Peter
http://raypeat.com/a...s/fishoil.shtml
From the provided link - Ray Peat writes-
"In declaring EPA and DHA to be safe, the FDA neglected to evaluate their antithyroid, immunosuppressive, lipid peroxidative (Song et al., 2000), light sensitizing, and antimitochondrial effects, their depression of glucose oxidation (Delarue et al., 2003), and their contribution to metastatic cancer (Klieveri, et al., 2000), lipofuscinosis and liver damage, among other problems."
I am a total clown, but I couldn't find the Ray Peat quoted studies. Can I have some help in finding them? If not, any PubMed links to the idea that EPA/DHA is needed in tiny amounts would be helpful to me. I am committed to 3.9 grams EPA/DHA a day. Funny thing, when I am cruising PubMed, I am always finding stuff that is the opposite of Ray Peat's viewpoint. And about the immune suppressive thing, all I see is an increase in anti-inflammatory prostaglandins with fish oil. Is that the immune system suppressive effect? Or is there more?