7 replies to this topic

[VinceG]

I have added a new (14th) theory of aging to my treatise ANTI-AGING FIREWALLS - THE SCIENCE AND TECHNOLOGY OF LONGEVITY. The theory is called Stem Cell Supply Chain Breakdown and you can find a comprehensive discussion of it and its relationship to other theories of aging by following the given link. "This theory holds that aging is due in large or major part to a breakdown in the healthy functioning of the stem cell supply chain. This breakdown may be due to problems in replication or differentiation of critical stem cell populations, depletions of such populations due to aging or pathological conditions, or age-related shutdown of key parts of the supply chain." Also I have posted an addendum to the theory in a long September 25 2009 blog entry The stem cell supply chain - closing the loop for very long lives.

Insofar as I know this theory is a new and original way of looking at aging, in large part based on very recent research. I welcome feedback and discussion about this work.
Vince Giuliano vegiuliano@comcast.net

[VidX]

I'll definitelly check it out. You are a great guy Vince, keep up the good work!

[DJS]

Well researched. When I have some time I want to take a closer look at your ideas.

[VidX]

Don't know if it's rellevant, but reading this - " Adult stem cells live in niches - stem cell microenvironments and the health of the stem cells and their ability to reproduce or differentiate both depend upon and condition the states of their niches. " - I remembered an experiment where old mice muscle was supplied with young blood, and muscle satellite cells acted like young again.

[VinceG]

Don't know if it's rellevant, but reading this - " Adult stem cells live in niches - stem cell microenvironments and the health of the stem cells and their ability to reproduce or differentiate both depend upon and condition the states of their niches. " - I remembered an experiment where old mice muscle was supplied with young blood, and muscle satellite cells acted like young again.

VidX
Actually I think that is quite relevant and, if my memory serves me right, that effect has been observed for stem cells under several circumstances. Something like that also holds for old guys with young girl friends. No kidding; it has been studied. Check out my blog post * Impact on longevity of older men being with younger women and frequent sexual intercourse

[niner]

Vince, you are an inspiration to us all. (All the guys, anyway...)

[VinceG]

Don't know if it's rellevant, but reading this - " Adult stem cells live in niches - stem cell microenvironments and the health of the stem cells and their ability to reproduce or differentiate both depend upon and condition the states of their niches. " - I remembered an experiment where old mice muscle was supplied with young blood, and muscle satellite cells acted like young again.

VidX
Actually I think that is quite relevant and, if my memory serves me right, that effect has been observed for stem cells under several circumstances. Something like that also holds for old guys with young girl friends. No kidding; it has been studied. Check out my blog post * Impact on longevity of older men being with younger women and frequent sexual intercourse

I just ran again across a publication relevant to this discussion Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
It is at http://www.rifters.c...egeneration.pdf and characterized aged progenitor cells as suffering from a decline in notch signaling. Companionship of the younger cells restores the notch signaling. See my blog post Niche, Notch and Nudge about the role of notch signaling in stem cells.
Vince

[VidX]

Yes Vince, that's the one I was talking about. Thanks for the link, a good chance to refresh my memory.