Magnesium
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onge
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ity
Advocacy & Research for Unlimited Lifespans
Posted 29 October 2009 - 01:22 AM
Posted 29 October 2009 - 02:13 AM
Edited by ajnast4r, 29 October 2009 - 02:14 AM.
Posted 29 October 2009 - 04:07 AM
my suggestion is 200mg, 50% DRI as albion glycinate
Posted 29 October 2009 - 04:18 AM
my suggestion is 200mg, 50% DRI as albion glycinate
The important question is, will it fit ?
Posted 29 October 2009 - 04:54 AM
Posted 29 October 2009 - 04:56 AM
Posted 29 October 2009 - 06:27 AM
If we don't overdose anything, there won't be much reason to take a partial dose. Magnesium is a problem due to its volume; that's why everyone uses oxide. It's not so much that it's cheap, it's more that it's small. Anyway, 200 mg is reasonable. The RDA is for all sources, not just supplements. People get magnesium from food and also from water. The upper limit on Mg is not all that much, as I recall.If it fits, I'd like to see a little more even, perhaps 250-300mg, considering some people will take partial doses of the multi. Not sure it will squeeze in though.
Posted 29 October 2009 - 06:31 AM
Posted 29 October 2009 - 06:40 AM
Posted 29 October 2009 - 07:37 AM
Posted 29 October 2009 - 07:47 AM
Posted 29 October 2009 - 03:03 PM
Posted 29 October 2009 - 07:44 PM
Posted 29 October 2009 - 08:38 PM
Unlike the other albion amino acid chelates I have not seen a study showing better absorption from magnesium. But the possible increased heavy metal absorption from citrate scares me. What is the evidence for magnesium aspartate?Haven't voted. Despite the hype, Mg glycinate isn't terribly well-absorbed. This review of published studies:
Ranade VV, Somber JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. Am J Therapeut. 2001 Sep-Oct;8(5):345-57.
... found a % mEq bioavailability of 23.5%, only marginally better than oxide; citrate is at 29.64 (if you're really doing this, make sure you get real, fully-reacted Mg citrate, not 'blends,' 'complexes,' etc), and true aspartate at 41.7.
Edited by Blue, 29 October 2009 - 08:38 PM.
Posted 30 October 2009 - 04:22 AM
J Am Coll Nutr. 1996 Feb;15(1):102-6.
The lack of influence of long-term potassium citrate and calcium citrate treatment in total body aluminum burden in patients with functioning kidneys.
Sakhaee K, Ruml L, Padalino P, Haynes S, Pak CY.
University of Texas Southwestern Medical Center at Dallas 75235-8885, USA.
BACKGROUND: It has been suggested that citrate salts might enhance aluminum (Al) absorption from a normal diet, posing a threat of Al toxicity even in subjects with normal renal function. We have recently reported that in normal subjects and patients with moderate renal failure, short-term treatment with tricalcium dicitrate (Ca3Cit2) does not significantly change urinary and serum Al levels. However, we have not assessed total body Al stores in patients on long-term citrate treatment. OBJECTIVE: The objective of this study was to ascertain body content of Al non-invasively using the increment in serum and urinary Al following the intravenous administration of deferoxamine (DFO) in patients with kidney stones and osteoporotic women undergoing long-term treatment with potassium citrate (K3Cit) or Ca3Cit2, respectively. METHODS: Ten patients with calcium nephrolithiasis and five with osteoporosis who were maintained on potassium citrate (40 mEq/day or more) or calcium citrate 800 mg calcium/day (40 mEq citrate) for 2 to 8 years, respectively, and 16 normal volunteers without a history of regular aluminum-containing antacid use participated in the study. All participants completed the 8 days of study, during which they were maintained on their regular home diet. Urinary Al excretion was measured during a two-day baseline before (Days 5, 6) and for 1 day (Day 7) immediately following a single intravenous dose of DFO (40 mg/kg). Blood for Al was obtained before DFO administration, and at 2, 5 and 24 hours following the start of the infusion. RESULTS: The median 24-hour urinary Al excretion (microgram/day) at baseline versus post-DFO value was 15.9 vs. 44.4 in the normal subjects and 13.3 vs. 35.7 in the patients. These values were all within normal limits and did not change significantly following DFO infusion (p = 0.003 and p = 0.0001, respectively). The median change of 17.1 micrograms/day in urinary Al in the normal subjects was not significantly different from the 18.7 micrograms/day change measured in the patient group (p = 0.30). Similarly, no change in the mean serum Al was detected at any time following the DFO infusion, either in the patient or control group (patients 4.1 to 4.3 ng/ml, controls 7.4 to 4.6 ng/ml). CONCLUSION: The results suggest that abnormal total body retention of Al does not occur during long-term citrate treatment in patients with functioning kidneys.
PMID: 8632109
Posted 30 October 2009 - 05:13 AM
Haven't voted. Despite the hype, Mg glycinate isn't terribly well-absorbed. This review of published studies:
Ranade VV, Somber JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. Am J Therapeut. 2001 Sep-Oct;8(5):345-57.
... found a % mEq bioavailability of 23.5%, only marginally better than oxide; citrate is at 29.64 (if you're really doing this, make sure you get real, fully-reacted Mg citrate, not 'blends,' 'complexes,' etc), and true aspartate at 41.7.
Posted 30 October 2009 - 05:25 AM
Posted 30 October 2009 - 06:10 AM
If Albion has unpublished data, maybe email them and ask for a copy? Maybe explain the project and that an Albion is being considered, and you just need more info.
Posted 30 October 2009 - 09:30 PM
Edited by FunkOdyssey, 30 October 2009 - 09:30 PM.
Posted 30 October 2009 - 09:36 PM
interesting i hadnt seen that.. albion cites a study claiming superior bioavailability but its unpublished.
aspartate would be the clear choice here.
Posted 30 October 2009 - 11:04 PM
I'm sure more people are sensitive to aspartate.
Posted 31 October 2009 - 05:22 AM
Edited by nameless, 31 October 2009 - 05:44 AM.
Posted 31 October 2009 - 09:46 PM
Posted 31 October 2009 - 11:54 PM
Maybe, but it might increase the bioavailability of other things as well, including things that you didn't want to be absorbing. For safety's sake it would be better to not go this route.4) Is it possible to increase the bioavailability of Magnesium/Calcium with other substances?
Posted 04 November 2009 - 04:45 PM
Ideas:
1) Put Magnesium and Calcium into a seperate pill to save space.
2) Use forms that also contain an other nutrient, like -ascorbate.
3) Don't use the form thats most bioavailable per mg Mg, but per mg total substance. ;-)
4) Is it possible to increase the bioavailability of Magnesium/Calcium with other substances?
Posted 04 November 2009 - 04:53 PM
I agree highly with number 1. If you want this to be something reasonable to take for others besides the most dedicated supplement takers minimizing the number of pills should be a concern
Ideas:
1) Put Magnesium and Calcium into a seperate pill to save space.
Edited by rwac, 04 November 2009 - 04:53 PM.
Posted 05 November 2009 - 05:20 AM
I agree highly with number 1. If you want this to be something reasonable to take for others besides the most dedicated supplement takers minimizing the number of pills should be a concern
Ideas:
1) Put Magnesium and Calcium into a seperate pill to save space.
You're assuming that the multi will even have Calcium, which is kinda unlikely, really.
Edited by shazam, 05 November 2009 - 05:22 AM.
Posted 09 November 2009 - 11:45 PM
Posted 30 December 2009 - 04:03 AM
Yes. Magnesium glycinate, 360 mg per day.
Posted 30 December 2009 - 09:13 PM
Magnesium is best taken at night on an empty stomach,
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