original thread
my suggestion still stands at 120mcg (100%DRI) as 60%k1 and 40%k2-mk7... i wouldnt mind additional mk4 but at what dose? are there any benefits seen in lower dosing?
Edited by ajnast4r, 05 November 2009 - 01:37 AM.
Posted 05 November 2009 - 01:20 AM
Edited by ajnast4r, 05 November 2009 - 01:37 AM.
Posted 05 November 2009 - 01:31 AM
Posted 05 November 2009 - 01:38 AM
No option for MK4 ?
Posted 05 November 2009 - 05:07 AM
Posted 05 November 2009 - 05:11 AM
Posted 05 November 2009 - 08:41 AM
K1 is useless. I'd go with 2- to 4mg Mk4 and 1- to 2mg Mk7.
Posted 05 November 2009 - 08:56 AM
Posted 05 November 2009 - 01:16 PM
Posted 05 November 2009 - 05:59 PM
Posted 05 November 2009 - 06:46 PM
I'd say go by studies. I think Rotterdam found a benefit using around 30-40 mcg of MK-4? Maybe go with something like a mix of both 45mcg MK-4, 45 mcg MK-7
Posted 05 November 2009 - 06:50 PM
Natto is gives MK-7, not MK-4. See this:I'd say go by studies. I think Rotterdam found a benefit using around 30-40 mcg of MK-4? Maybe go with something like a mix of both 45mcg MK-4, 45 mcg MK-7?
I wouldn't go into mg ranges for MK-7. Duke, what evidence is there that 1-2 mg of MK-7 is a benefit and not dangerous? Natto studies would be what to look at there, and I think a typical serving of natto is in the 200-400mcg range or so. I recall one study where the participants just consumed a couple of servings a week, they didn't eat multiple packs daily.
Posted 05 November 2009 - 06:58 PM
Posted 05 November 2009 - 07:09 PM
Posted 05 November 2009 - 07:38 PM
Very interesting to see the results of that one when they arrive. Here is another one. A 3 year study. They are betting on 180 mcg MK-7 so this is likely the best guestimate at this moment:There is one clinical study I recall where they were testing for the optimal MK-7 dosage --
http://clinicaltrial...8...mk-7&rank=4
Study has been completed, but data isn't out yet (that I know of). Maybe someone could find bits of released data or contact study authors?
Edited by Blue, 05 November 2009 - 07:39 PM.
Posted 05 November 2009 - 07:43 PM
K1 is useless. I'd go with 2- to 4mg Mk4 and 1- to 2mg Mk7.
Way high.
As for my views, they're in the original thread that the op thoughtfully linked.
Posted 05 November 2009 - 07:43 PM
Posted 05 November 2009 - 08:04 PM
K1 is useless. I'd go with 2- to 4mg Mk4 and 1- to 2mg Mk7.
Way high.
As for my views, they're in the original thread that the op thoughtfully linked.
Not way high. I take 5mg MK4 each day:
http://www.iherb.com...ules/14812?at=0
I do hear things about making sure to be cautious about your intake, since they can all (meaning K1 as well) convert to mendione in the liver and increase your risk of cancer... apparantly, though more research is needed, so this may be more of a cautionary view.
Edited by shazam, 05 November 2009 - 08:04 PM.
Posted 05 November 2009 - 10:26 PM
Yes, all epidemological evidence I know of proves superiority or non-inferiority of MK-7 (and/or long chain vitamers, or a mix of all MK-ns). I've wanted to post on the issue in MR's regimen thread and try to put the MK-4 myth to rest, but it's not likely to happen any time soon (i.e. this week or weekend).In short, all the epidemiological evidence argues for MK-7.
Edited by kismet, 05 November 2009 - 11:08 PM.
Posted 05 November 2009 - 11:11 PM
Posted 06 November 2009 - 10:41 AM
ok so what it boils down to is, is there any evidence that mk4 will do anything at such low doses? as far as i can tell the only evidence for mk4 is from the japanese studies which all used mg amounts, not the mcg amounts suggested for this project.
putting in mk4 in mcg amounts bc it looks good would be a waste... i would rather see 100mcg of mk7 and no mk4 if thats what the evidence suggests is best.
Posted 06 November 2009 - 11:08 AM
Posted 06 November 2009 - 07:25 PM
If it's one or the other, I'd say go with MK-7. The only reason to include mcg levels of MK-4 is if you want to cover all bases, or if MK-7 is too expensive. On a ingredient by ingredient basis, I expect MK-7 may be one of the more expensive vitamins in the product.ok so what it boils down to is, is there any evidence that mk4 will do anything at such low doses? as far as i can tell the only evidence for mk4 is from the japanese studies which all used mg amounts, not the mcg amounts suggested for this project.
putting in mk4 in mcg amounts bc it looks good would be a waste... i would rather see 100mcg of mk7 and no mk4 if thats what the evidence suggests is best.
Edited by nameless, 06 November 2009 - 07:26 PM.
Posted 07 November 2009 - 12:37 AM
Interesting if the product included a true mix, MK4-MK10, along with a decent dose of MK-7, although that may be tricky to find a source for. Unless some MK-7 products include extra menaquinones naturally.
Posted 07 November 2009 - 12:43 AM
Interesting if the product included a true mix, MK4-MK10, along with a decent dose of MK-7, although that may be tricky to find a source for. Unless some MK-7 products include extra menaquinones naturally.
IIRC NOW makes a product with mixed menaquinones. MK7 and above.
It's also cheaper than straight MK7.
Posted 07 November 2009 - 06:18 AM
Interesting if the product included a true mix, MK4-MK10, along with a decent dose of MK-7, although that may be tricky to find a source for. Unless some MK-7 products include extra menaquinones naturally.
IIRC NOW makes a product with mixed menaquinones. MK7 and above.
It's also cheaper than straight MK7.
yea the k2 i take from now is derived from natto and contains mk7 + other menaquinones
Posted 07 November 2009 - 06:27 AM
Posted 07 November 2009 - 08:08 AM
Interesting. I think I've read that before. I've heard testimonials of MK4 dosages stopping bleeding extremely fast at 5mg before. Still worth looking into the potential negative ramifications of supplementing that high, but very interesting. It's entirely possible that it does that at lower dosages. Does anyone know why they dose so high? Is it because MK4 is typically syntethic/less bioavailable or something?Stevenson et al. from Sheffield have just published a huge report on vitamin K and its use to prevent fractures. The full text is here. It's a meta analysis of the ECKO trial of 5mg K1 against placebo and 4 MK4 studies. It discusses some epidemiology in Japanese women; in one part of Japan where natto consumption is high, the blood levels of MK7 are a lot higher than in the Hiroshima area, and the women with higher levels of MK7 have less fractures. Stephan at WholeHealthSource has a post titled Are the MK-4 and MK-7 Forms of Vitamin K2 Equivalent?.
It's worth looking at, as he lays out the case against MK7 in favor of MK4. LEF sells a vitamin K supplement with 1mg K1, 1mg MK-4, and 100mcg MK-7. It is surprisingly cheap for LEF.
Edited by shazam, 07 November 2009 - 08:12 AM.
Posted 07 November 2009 - 07:02 PM
Edited by kismet, 07 November 2009 - 07:03 PM.
Posted 17 November 2009 - 07:14 PM
Edited by drmz, 17 November 2009 - 07:16 PM.
Posted 17 November 2009 - 07:29 PM
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