I haven't read up on this much but I know that turmeric is suppose to be a good anti-inflammatory as well as a plethora of other benefits. But is it the best supplement for this? If there are any better what are they?
![](http://www.longecity.org/images/ImmInstLOGO.gif)
Posted 20 November 2009 - 10:20 PM
Posted 20 November 2009 - 10:24 PM
Edited by shaggy, 20 November 2009 - 10:25 PM.
Posted 20 November 2009 - 10:27 PM
Posted 20 November 2009 - 10:29 PM
Posted 20 November 2009 - 11:11 PM
curcumin WITH BIOPERINE, and grape seed extract are prolly some of the best...also noni has been showing good signs
Meat
Posted 20 November 2009 - 11:42 PM
Posted 20 November 2009 - 11:52 PM
Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.
Posted 20 November 2009 - 11:55 PM
NSAIDs
Boswellic acids, aka acetyl-11-keto-beta-boswellic acid (AKBA)
Wait, that's 2.......
Posted 20 November 2009 - 11:58 PM
Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.
it has been proven that curcumin is very poorly absorbed, i wanna say around 5%(without Bioperine)! so it is imperative that bioperine is added, as most products do contain it already
How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.
Posted 21 November 2009 - 12:06 AM
Posted 21 November 2009 - 12:53 AM
Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.
it has been proven that curcumin is very poorly absorbed, i wanna say around 5%(without Bioperine)! so it is imperative that bioperine is added, as most products do contain it already
How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.
Nice copy and paste.. But little substance in Bioperine's efficacy at improving bioavalabity of curcumin in humans.
If absorbtion of curcumin is 5%, what is it with added bioperine?
Posted 21 November 2009 - 01:00 AM
Bioperine does enhance absorption, but this explanation is just BS.How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.
Posted 21 November 2009 - 03:09 AM
Bioperine does enhance absorption, but this explanation is just BS.How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.
Posted 21 November 2009 - 03:21 AM
Piperine (Bioperine) is a 3A4 inhibitor, and like many 3A4 inhibitors, it is a PGP efflux pump inhibitor. Any compound that is pumped out ("anti-absorbed") by PGP will be absorbed better in the presence of piperine. Piperine is also said to alter the microstructure of the intestinal brush border in ways that enhance absorption. Depending on species, piperine may alter phase II metabolic enzymes, but this doesn't appear to be the case in humans. It has some fairly complicated effects on pharmacokinetics. It shows a fairly substantial effect on the absorption of curcumin. The question that you have to ask yourself about piperine is what else is it helping to get in? Something you don't want in?you gotta a better explanation.....Bioperine does enhance absorption, but this explanation is just BS.How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.
Posted 21 November 2009 - 05:44 AM
Bioperine does enhance absorption, but this explanation is just BS.How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.
Posted 21 November 2009 - 06:31 AM
I don't see how thermogenesis is going to substantially alter pharmacokinetics. It's basically a bunch of speculation and marketing talk. They do give a nod toward the literature, talking about the micelle formation, AA active t'port, and some reference the epithelial cell wall. The whole thing seems marketing-oriented, kind of obfuscutory, and not super consumer-friendly.this better?
A thermonutrient such as BioPerine would potentially improve the process of nutrient absorption by
enhancing thermogenesis. The leading theory of food-induced thermogenesis relates to the autonomous
nervous system. The autonomous nervous system is represented by two main receptors in the
gastrointestinal tract, the alpha and beta adrenergic receptors.
Most of the food or thermonutrient-induced thermogenesis is facilitated by beta receptors, which
include a compound known as cyclic adenosine 3’, 5’ monophosphate (cAMP). The role of cAMP as a
"second messenger" to the hormonal and enzymatic actions in the body is well recognized. When
thermogenesis occurs, the demand for fresh nutrients to sustain the metabolic processes rapidly
increases.
Piperine has been found in independent studies to stimulate the release of catecholamines, thermogenic
hormones whose action is made possible by the presence of cAMP. However, the nature of the
thermogenic response mediated by catecholamines is relatively short-lived. Therefore the window of
opportunity for piperine-induced thermogenesis and enhanced nutrient absorption is narrow.
These thermogenic properties may explain how a small amount of BioPerine(5 mg) can afford such a
profound effect on serum nutrient levels (as shown in our studies on water soluble, fat soluble and
botanical ingredients). It is possible that when piperine is ingested, it has a localized thermogenic
effect on epithelial cells which increase the uptake of nutrients.
Other mechanisms by which piperine stimulates nutrient absorption have also been discussed in
literature. These include increased micelle formation, stimulation of active transport of amino acids
(gamma-glutamyl transpeptidase), and epithelial cell wall modification due to the affinity of piperine
towards fats and fatty substances.
In view of these findings it is proposed that piperine ingested in relatively small amounts would act as
a thermonutrient. Localized thermogenic action on the epithelial cells would in turn increase the rate of
absorption of supplemented nutrient(s)
Posted 21 November 2009 - 07:55 AM
Petroleum ether extract of Cissus quadrangularis (Linn.) enhances bone marrow mesenchymal stem cell proliferation and facilitates osteoblastogenesis.
Potu BK, Bhat KM, Rao MS, Nampurath GK, Chamallamudi MR, Nayak SR, Muttigi MS.
Department of Anatomy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
OBJECTIVE: To evaluate the effects of the petroleum ether extract of Cissus quadrangularis on the proliferation rate of bone marrow mesenchymal stem cells, the differentiation of marrow mesenchymal stem cells into osteoblasts (osteoblastogenesis) and extracellular matrix calcification. This study also aimed to determine the additive effect of osteogenic media and Cissus quadrangularis on proliferation, differentiation and calcification. METHODS: MSCs were cultured in media with or without Cissus quadrangularis for 4 weeks and were then stained for alkaline phosphatase. Extracellular matrix calcification was confirmed by Von Kossa staining. marrow mesenchymal stem cells cultures in control media and osteogenic media supplemented with Cissus quadrangularis extract (100, 200, 300 microg/mL) were also subjected to a cell proliferation assay (MTT). RESULTS: Treatment with 100, 200 or 300 microg/mL petroleum ether extract of Cissus quadrangularis enhanced the differentiation of marrow mesenchymal stem cells into ALP-positive osteoblasts and increased extracellular matrix calcification. Treatment with 300 microg/mL petroleum ether extract of Cissus quadrangularis also enhanced the proliferation rate of the marrow mesenchymal stem cells. Cells grown in osteogenic media containing Cissus quadrangularis exhibited higher proliferation, differentiation and calcification rates than did control cells. CONCLUSION: The results suggest that Cissus quadrangularis stimulates osteoblastogenesis and can be used as preventive/ alternative natural medicine for bone diseases such as osteoporosis.
PMID: 19841707 [PubMed - in process]
J Ethnopharmacol. 2007 Mar 21;110(2):264-70. Epub 2006 Sep 26.
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.
Panthong A, Supraditaporn W, Kanjanapothi D, Taesotikul T, Reutrakul V.
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. apanthon@mail.med.cmu.ac.th
Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.
PMID: 17095173 [PubMed - indexed for MEDLINE]
Edited by abelard lindsay, 21 November 2009 - 07:55 AM.
Posted 21 November 2009 - 12:16 PM
Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.
it has been proven that curcumin is very poorly absorbed, i wanna say around 5%(without Bioperine)! so it is imperative that bioperine is added, as most products do contain it already
How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.
Nice copy and paste.. But little substance in Bioperine's efficacy at improving bioavalabity of curcumin in humans.
If absorbtion of curcumin is 5%, what is it with added bioperine?
bioperine enhances curcumins BA several hundred fold:
Posted 21 November 2009 - 12:34 PM
Posted 21 November 2009 - 03:47 PM
Posted 21 November 2009 - 05:49 PM
Edited by hyper_ventriloquism, 21 November 2009 - 05:50 PM.
Posted 13 July 2011 - 07:13 AM
Posted 15 July 2011 - 02:54 PM
The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages.
Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK.
Source
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Korea.
Abstract
Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals, including humans. In the present study, we demonstrated the anti-inflammatory effects of MSM in lipopolysaccharide (LPS)-stimulated murine macrophages, RAW264.7 cells. MSM significantly inhibited the release of nitric oxide and prostaglandin E(2) by alleviating the expression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated RAW264.7 cells. Furthermore, the levels of interleukin-6 and tumor necrosis factor-alpha were decreased by MSM treatment in cell culture supernatants. Further study indicated that the translocation of the p65 subunit of nuclear factor (NF)-kappaB to the nucleus was inhibited by MSM treatment in LPS-stimulated RAW264.7 cells, in which it helped block degradation of inhibitor of NF-kappaB. In addition, in vivo studies demonstrated that topical administration of MSM at 500-1250 microg/ear resulted in similar inhibitory activities in 12-O-tetradecanoylphorbol 13-acetate-induced mouse ear edema. Collectively, theses results indicate that MSM inhibits LPS-induced release of pro-inflammatory mediators in murine macrophages through downregulation of NF-kappaB signaling.
Posted 19 April 2013 - 04:33 PM
Edited by golgi1, 19 April 2013 - 04:55 PM.
Posted 19 April 2013 - 09:33 PM
Posted 19 April 2013 - 09:58 PM
C60-olive oil is useful against certain kinds of chronic inflammation.
Edited by golgi1, 19 April 2013 - 10:01 PM.
Posted 20 April 2013 - 06:16 AM
Posted 20 April 2013 - 02:49 PM
Posted 20 April 2013 - 04:24 PM
0 members, 1 guests, 0 anonymous users