284 replies to this topic

[Colli]

ALCAR/ALA combined supplement: turned me into a stammering wreck - not good when I already suffer from a particularly crippling case of social anxiety. Seriously, I couldn't string a sentence together without tripping over virtually every word. When I stopped using it, the stuttering went away. I have since investigated this effect and it seems more likely that ALA was the culprit.

Deprenyl: made me feel that life just wasn't worth the struggle.

Niacin/niacinamide: did help my social anxiety a little, but unfortunately it gave me a persistant cough and chest tightness.

Edited by Colli, 10 February 2010 - 01:51 PM.

[wayside]

Something in Jarrow Neuro Optimizer gives me massive headaches (CDP Choline, Phosphatidylcholine, Phosphatidylserine, ALCAR, ALA, Glutamine, Taurine). Pretty sure it's not the taurine, energy drinks don't give me a headache.

Some brands of green tea extract give me massive heartburn.

[stephen_b]

Something in Jarrow Neuro Optimizer gives me massive headaches

My experience too.

[tintinet]

I've taken most every supplement mentioned in this thread without notable effect, positive or negative, with rare exception. The only things that I think really gave me horrible reactions were 'energy' type supplements with various ingredients like evodiamine. These gave me really severe anhedonia, dysphoria, and malaise.

[Lufega]

Cordyceps - Increases energy, stamina, libido and breathing capacity. I didn't feel winded even when working out. Actually, this one is a pretty good supplement. Only downside is that It gave me anxiety and put me in a lousy mood.

Astragalus - Improved my immune status and I felt more tone/muscular while I was on it. Again, this is all positive except I have a known condition where raising your immune function is contra-indicated.

[HaloTeK]

Pycnogenol: massive headaches, I really wanted this substance to work for me.

pantethine: great for clearing up any kind of acne or skin problems, not so good for my head (headaches).

ALCAR: feel great energy, not so good for my head (headaches), hemorrhoidal symptoms after about 2 weeks on the substance (probably because of ALCARs effect on the stress AXIS.

rhodiola rosea, gynostemma: once again, great energy, not so good for my head (headaches).

fish oil: mania from DHA doses over 1gram after about a weeks time, I couldn't even sleep.

magnesium, epsom salts: mania and lethegy from typical dosages.

olive leaf extract: acne breakouts.

vitamin k2: low blood sugar (90mg mk-7 3x a week did this).

calcium: tingling sensations in my fingers (500mg daily).

lactoferrin: great for clearing up the skin, but gave me heart burn.




Side note: I normally never get headaches.

[niner]

Wow HaloTek, that's a lot of adverse events. It sounds like a strategy of minimal dosing would be a good idea.

[Lufega]

Melatonin - gynecomastia. Well, it made worse what was already there

[rwac]

...except I have a known condition where raising your immune function is contra-indicated.

You're assuming that your autoimmune issue does not have an infectious origin.

[Ben]

Melatonin - gynecomastia. Well, it made worse what was already there

Are you serious? I'm worried about this too. Have you any papers on this? Any info? I've scoured the net about 4 times quite thoroughly and each time came up with nothing substantial.


For me: Bacopa (quality AOR) - Makes me too sleepy and there is an anxiety come down.

[Ungomma]

During my 2nd week on it Deprenyl (not a supplement though) started to cause EXTREME night-time fears which were then followed by hallucinations of presense and one instance of auditory hallucination (radio noise).

Nasty!

[pycnogenol]

During my 2nd week on it Deprenyl (not a supplement though) started to cause EXTREME night-time fears which were then followed by hallucinations of presense and one instance of auditory hallucination (radio noise).

Nasty!

How much Deprenyl were you taking to cause this unfortunate side effect?

[Lufega]

...except I have a known condition where raising your immune function is contra-indicated.

You're assuming that your autoimmune issue does not have an infectious origin.

I wonder, rwac, how astragalus would fare against someone who is Lyme positive. The dose range is 5-15 grams daily.

[Lufega]

Melatonin - gynecomastia. Well, it made worse what was already there

Are you serious? I'm worried about this too. Have you any papers on this? Any info? I've scoured the net about 4 times quite thoroughly and each time came up with nothing substantial.

This review referenced a paper titled "melatonin and painful gynecomastia" but I can't access the full study or abstract.

http://content.nejm..../full/336/3/186

[rwac]

I wonder, rwac, how astragalus would fare against someone who is Lyme positive. The dose range is 5-15 grams daily.

It made me feel quite a bit better, so I took astragalus extract for a while.

I don't know if it was good for me in the end. Plus, this was along with antibiotics, so it's possible that driving my immune system towards th1 was a good thing. So it's confusing.

Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice.

Chen W, Li YM, Yu MH.

Department of Geriatrics, Huashan Hospital, Fudan University of Shangai, China.

Abstract

BACKGROUND: Type 1 diabetes mellitus (DM) is a chronic autoimmune disease that is related to the disequilibrium state of Th1 and Th2 subgroups of helper T lymphocyte (Th) and their cytokines. Astragalus polysaccharides (APS) are bioactive components extracted from one of the traditional Chinese herbs, used to enhance the function of human immune system. OBJECTIVE: To investigate the effects of APS on preventing type 1 DM and Th1/Th2-subtype cytokines, we compared the results of administration of APS and normal saline (NS) on non-obese diabetic (NOD) mice. SUBJECTS AND METHODS: APS or NS was administered to 4-week-old mice at a dose of 2.0 g/kg per day for 10 weeks. At 40 weeks, blood glucose, serum C-peptide (C-P) and GAD antibody were measured; pancreas was examined histologically; the intra-islet lymphocyte infiltration and T lymphocyte subsets in the spleen were analysed; the gene expression of IL-1 beta, IL-2, IL-6, IL-12, TNF-alpha, INF-gamma, IL-4, IL-5, IL-10, TGF-beta, Bcl-2, SOD, Fas and iNOS were measured by RT-PCR. RESULTS: The results showed that APS-administered NOD mice had a lower incidence rate of type 1 DM, lower serum C-P level, better histologic findings of pancreatic islets, and a lower D4+/CD8+ ratio of T lymphocytes from the spleen and the infiltrated islets. RT-PCR analysis showed gene expression levels are lower in IL-1 beta, IL-2, IL-6, IL-12, TNF-alpha, INF-gamma, Fas, iNOS, and higher in IL-4, IL-5, IL-10, TGF-beta, Bcl-2, SOD in the pancreatic tissue from APS-administered NOD mice as compared to the NS group. CONCLUSIONS: These results demonstrated the effects of Astragalus polysaccharides on the prevention of type 1 DM in NOD mice by correcting the imbalance between the Th1/Th2 cytokines.

http://www.ncbi.nlm.nih.gov/pubmed/18924264

[FunkOdyssey]

I wonder, rwac, how astragalus would fare against someone who is Lyme positive. The dose range is 5-15 grams daily.

It made me feel quite a bit better, so I took astragalus extract for a while.

I don't know if it was good for me in the end. Plus, this was along with antibiotics, so it's possible that driving my immune system towards th1 was a good thing. So it's confusing.

This is the primary reason I now avoid intentional attempts to push the immune system in a particular direction. Its virtually impossible to understand the current state of your Th1 vs Th2 balance (which is already in itself a grossly reductionist idea) without counts of every specific immune cell type (by surface markers), levels of every cytokine, etc. Hell, even if you had all of that information, you'd still be somewhat arrogant to presume to comprehend what is going on.

I hold LDN as an exception since health outcomes with its use for a huge variety of problems seem to be excellent. I do not claim to fully understand how it works.

[FunkOdyssey]

I hold LDN as an exception since health outcomes with its use for a huge variety of problems seem to be excellent. I do not claim to fully understand how it works.

I'd like to revise that statement, having broadened my horizons a little more and counted another ~50 or so anecdotes, results with LDN are quite mixed in various conditions including both CFS and Lyme. Seems to be very hit or miss with some improving, some worsening, and some seeing no changes.

I'll add another adverse reaction: methylcobalamin reproducibly causes bad physical anxiety, with agitation and chest tightness. Not good. No such reaction from methylfolate (another methyl donor) or cyanacobalamin, so it seems to be very specific to methylcobalamin.

[Lufega]

I'll add another adverse reaction: methylcobalamin reproducibly causes bad physical anxiety, with agitation and chest tightness. Not good. No such reaction from methylfolate (another methyl donor) or cyanacobalamin, so it seems to be very specific to methylcobalamin.

I had this same reaction to methylcobalamine which is why I stopped it a couple of years ago. It probably means your body is saturated with it. My cousin also started using it. He likes how edgy it makes him but I notice that he too, became anxious even doing some nail-bitting. Can't convince him to get off it though..

[iago]

Buproprion SR. This made me extra sleepy and more depressed. XL had the opposite effect (until my insurance company decided I could only get generics, then the XL was useless).

[rwac]

I'll add another adverse reaction: methylcobalamin reproducibly causes bad physical anxiety, with agitation and chest tightness. Not good. No such reaction from methylfolate (another methyl donor) or cyanacobalamin, so it seems to be very specific to methylcobalamin.

I had this same reaction to methylcobalamine which is why I stopped it a couple of years ago. It probably means your body is saturated with it. My cousin also started using it. He likes how edgy it makes him but I notice that he too, became anxious even doing some nail-bitting. Can't convince him to get off it though..

Interesting. You guys ought to try taking equal amounts of methyl-B12 and adenosyl-B12.
I've got some good effects from Thorne B Complex #12.

Quercetin (250mg): I got a feeling of an impending asthma attack. I used to be asthmatic as a child, but I haven't had an attack in years.

[FunkOdyssey]

I'll add another adverse reaction: methylcobalamin reproducibly causes bad physical anxiety, with agitation and chest tightness. Not good. No such reaction from methylfolate (another methyl donor) or cyanacobalamin, so it seems to be very specific to methylcobalamin.

I had this same reaction to methylcobalamine which is why I stopped it a couple of years ago. It probably means your body is saturated with it. My cousin also started using it. He likes how edgy it makes him but I notice that he too, became anxious even doing some nail-bitting. Can't convince him to get off it though..

Interesting. You guys ought to try taking equal amounts of methyl-B12 and adenosyl-B12.
I've got some good effects from Thorne B Complex #12.

Quercetin (250mg): I got a feeling of an impending asthma attack. I used to be asthmatic as a child, but I haven't had an attack in years.

Sublingual administration might have had something to do with it, and I was also taking a full milligram.

I might try the thorne basic b-complex, has slightly lower doses of B12 as well as superior forms of the other b-vitamins: http://www.iherb.com...Caps/18791?at=1

Edited by FunkOdyssey, 25 September 2010 - 01:26 PM.

[e Volution]

Potassium Gluconate powder gave me wicked Diarrhea lol...

[Lufega]

Gotu Kola and copper made me gain ~ 25 lbs. They both inhibit lipolysis. I'm unsure if Carnosine also played a part.

Regulation of sympathetic nerve activity by L-carnosine in mammalian white adipose tissue.
Shen J, Yao JF, Tanida M, Nagai K.

Institute for Protein Research, Osaka University, Suita, Osaka, Japan. jshen@anbas.co.jp <jshen@anbas.co.jp>


Abstract
Previously, we showed that l-carnosine, a bioactive dipeptide, influences the sympathetic nerve activity innervating kidney and brown adipose tissue. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we investigated the in vivo effects of L-carnosine on the sympathetic nerve activity innervating white adipose tissue (SNA-WAT) and lipolysis. We found that intraperitoneal (ip) administration of L-carnosine at doses of 100 ng/rat and 10 microg/rat elevated and suppressed SNA-WAT, respectively. The effect of lower dose of L-carnosine (100 ng/rat) was eliminated by pretreatment with diphenhydramine hydrochloride, a histamine H(1) receptor antagonist. In contrast, the effect of higher dose of L-carnosine (10 microg/rat) was suppressed by thioperamide maleate salt, a histamine H(3) receptor antagonist. Moreover, ip administration of 100 ng and 10 microg of L-carnosine increased and decreased the levels of plasma free fatty acids (FFAs), respectively. The changes of plasma FFAs resulting from the exposure to 100 ng and 10 microg of L-carnosine were diminished by the beta-adrenergic receptor blocker propranolol hydrochloride and the muscarinic receptor blocker atropine sulfate, respectively; and eliminated by the corresponding histamine receptor antagonists, which eliminated the changes in SNA-WAT. Our results suggest that low doses of L-carnosine may regulate the lipolytic processes in adipose tissue through facilitation of the sympathetic nervous system, which is driven by histamine neurons through the H(1) receptor, and that the beta(3)-receptor may be involved in this enhanced lipolytic response. High doses of L-carnosine, on the other hand, may lower lipolysis by suppressing sympathetic nerve activity via the H(3) receptor, and the muscarinic receptor may be related to this response.

Not sure if 500 mg is considered a high dose or low dose but the weight gain is there. Stopping these three seems to be reversing the problem.

Edited by Lufega, 25 September 2010 - 03:29 PM.

[tintinet]

Oddly, NSI Green Tea seemed to give me really nasty anxiety/depression, or at least exacerbate any I had underlying.

[FunkOdyssey]

Oddly, NSI Green Tea seemed to give me really nasty anxiety/depression, or at least exacerbate any I had underlying.

I've had good luck with the NOW Foods EGCG, it's 400mg of green tea extract containing 200mg EGCG. I'd be interested to see your response to that instead.

[hamishm00]

Also using that product now as well. Seems to be the perfect dosage.

[cathological]

ExtenZe!!! I was hard for ten days!

[Steve_86]

Deprenyl - nearly broke up with my girlfriend (now wife) due to intolerant a$hole behavior

What dose were you taking?

[FunkOdyssey]

Deprenyl - nearly broke up with my girlfriend (now wife) due to intolerant a$hole behavior

What dose were you taking?

5mg, I should have taken more though, breaking up with her earlier would have been in my best interest. Hindsight is 20/20.

[Steve_86]

Deprenyl - nearly broke up with my girlfriend (now wife) due to intolerant a$hole behavior

What dose were you taking?

5mg, I should have taken more though, breaking up with her earlier would have been in my best interest. Hindsight is 20/20.

Haha, it sounds like a useful tool for dealing with relationship problems.

Currently I'm taking 1.25mg per day but haven't noticed any change in my behaviour.