37 replies to this topic

[2tender]

Agreed. We are off topic here, but the point that I want to make is that safe supplimenting is smart. If a person has pre-existing health problems they should consult their physician and/or do their research before taking anything. If a person decides to use the supplement, they should use the best available and use their own best judgement regarding its continued use. With something like "Sweets syndrome" I would ask my Physician before using Resveratrol (I know easier said.than done) and discontinue anything that gives a rash or enhances other symptoms., the better off you are. As for 5HTP, I havent tried it, if taking it once a wk works for you Im glad to hear it. I think that modest and moderate supplement intake is prudent..

Edited by 2tender, 04 September 2010 - 01:08 AM.

[niner]

Anyway, the gist of this is that I am being cautious about RSV now and waiting a few days to make sure that whatever it is in macrolides that makes them inhibit cytochrome P450 pathways has no relation to whatever it is in RSV that elicits the same behavior. Nobody really understands T cell-mediated hypersensitivity reactions, and especially weird, off the map ones like Sweet's Syndrome, which has been incorrectly characterized in the science to date more than it has been correctly characterized on a number of fronts.

Welcome to ImmInst, leha! Your hypersensitivity to macrolides is unlikely to be related in any direct way to P450 inhibition. The list of things that inhibit P450s is as long as your arm. Longer, in fact. P450s are a large class of enzymes whose main job is the oxidation of any foreign molecule that you might happen to ingest. It's the nature of these enzymes that whatever is a substrate for them is frequently also an inhibitor, so there are a hell of a lot of inhibitors of them. Resveratrol's ability to inhibit P450s is not particularly potent, as these things go.

[happyhammet]

leha, you should not take resveratrol while you are on medications that depend on P450 metabolism.
Resveratrol is a potent P450 inhibitor.

http://www.ncbi.nlm....pubmed/20027150

[maxwatt]

Reveratrol does modulate C450 enzymes, though the effect is much less than say grapefruit, which one is warned not to eat while taking certain medications. The effect of inhibition is to make the medication more potent, as if one is taking a larger dose. The exact interactions are unknown, and vary with an individual's phenotype. Resveratrol can both inhibit and induce different enzymes. But as niner said, it's not likely to be a problem under most circumstances.

Cancer Prev Res (Phila Pa). 2010 Sep;3(9):1168-75. Epub 2010 Aug 17.
Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study.
Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS.

Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724. schow@azcc.arizona.edu.
Abstract
Resveratrol has been shown to exhibit cancer-preventive activities in preclinical studies. We conducted a clinical study to determine the effect of pharmacologic doses of resveratrol on drug- and carcinogen-metabolizing enzymes. Forty-two healthy volunteers underwent baseline assessment of cytochrome P450 (CYP) and phase II detoxification enzymes. CYP1A2, CYP2D6, CYP2C9, and CYP3A4 enzyme activities were measured by the metabolism of caffeine, dextromethorphan, losartan, and buspirone, respectively. Blood lymphocyte glutathione S-transferase (GST) activity and GST-pi level and serum total and direct bilirubin, a surrogate for UDP-glucuronosyl transferase (UGT) 1A1 activity, were measured to assess phase II enzymes. After the baseline evaluation, study participants took 1 g of resveratrol once daily for 4 weeks. Enzyme assessment was repeated upon intervention completion. Resveratrol intervention was found to inhibit the phenotypic indices of CYP3A4, CYP2D6, and CYP2C9 and to induce the phenotypic index of 1A2. Overall, GST and UGT1A1 activities were minimally affected by the intervention, although an induction of GST-pi level and UGT1A1 activity was observed in individuals with low baseline enzyme level/activity. We conclude that resveratrol can modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogenesis. However, pharmacologic doses of resveratrol could potentially lead to increased adverse drug reactions or altered drug efficacy due to inhibition or induction of certain CYPs. Further clinical development of resveratrol for cancer prevention should consider evaluation of lower doses of resveratrol to minimize adverse metabolic drug interactions. Cancer Prev Res; 3(9); 1168-75. ©2010 AACR.

PMID: 20716633

[APBT]

maxwatt

How goes your Resveratrol and Melatonin trial; anything new to report?

[maxwatt]

maxwatt

How goes your Resveratrol and Melatonin trial; anything new to report?

It works in so far as I can take res at night and have no problem sleeping.

[hamishm00]

I have also been taking resv and melatonin in a similar fashion to max for about two years now. Never had an issue with sleeping. But that's kind of a pointless statement because I have had never had a problem with sleeping, ever, and I have never not taken resveratrol during the day/night without taking melatonin in the evening.

[2tender]

Thanks for posting that. I dont think you would be using Resveratrol that long without perceived and/or obvious benefits. You could post what they are, couldnt you? Also what type and dose are you using. Thanks!