A new entry on V.Guliano blog, I recommend reading it, very interesting. Kind of "More and more dots are connecting" situation.. Sirt3, mitochondria, energy metabolism, p53, cell cycle arrest, induction of senescence (to avoid cancer), mitochondrial ROS relation to cancer, the role (possibly a main one) of a mitochondria in CR, all the downstream interactions, etc...
http://anti-agingfir...ledge-of-aging/
Those of you who have put together jigsaw puzzles know that every once in a while a piece is found that links together several seemingly unrelated chunks of the puzzle. The sirtuin SIRT3 is doing that for several chunks of the aging/longevity puzzle, showing a key way in which the Oxidative Damage and theMitochondrial Damage theories of aging fit together and how these fit with the known life-extending properties of calorie restriction, with the role of exercise, response to stress and PGC – 1alpha, cell metabolism, several age-related diseases includingobesity, diabetes and Alzheimer's Disease, the FOXO gene family, and actions of P53, and with the actions of the dietary polyphenol resveratrol. Much of the relevant research is quite recent.
Edited by VidX, 22 January 2011 - 09:36 PM.
