52 replies to this topic

[sunshinefrost]

I noticed when taking IDEBENONE my skin gets healthy and tight. Amazing! Like CoQ10, this stronger ubiquinone is now implemented in some of the creams but very hard to find. It makes sense, nivea is already making cream with CoQ10 and it works pretty good.

[Athanasios]

I noticed when taking IDEBENONE my skin gets healthy and tight. Amazing! Like CoQ10, this stronger ubiquinone is now implemented in some of the creams but very hard to find. It makes sense, nivea is already making cream with CoQ10 and it works pretty good.

Just a heads up for those who want to try this, make sure to spot test it if you haven't used it before. More people have adverse reactions, rash, to this vs. CoQ10.

[Justchill]

anybody has a source for such creams?

[Anthony_Loera]

I noticed when taking IDEBENONE my skin gets healthy and tight. Amazing! Like CoQ10, this stronger ubiquinone is now implemented in some of the creams but very hard to find. It makes sense, nivea is already making cream with CoQ10 and it works pretty good.

Hmmm...

I don't know.
Seems like Resveratrol may be better than Idebenone according to some folks, see attached.
 Skin Care Formulation.pdf   120.05KB   51 downloads

Here we report a resveratrol-based skin care formulation, with 17 times greater antioxidant activity than idebenone. The role of resveratrol in prevention of photoaging is reviewed and compared with other antioxidants used in skin care products.

[Dmitri]

Has anyone tried pure vitamin E creams ala http://www.iherb.com...113-g/3848?at=0

I'm guessing it works in a similar way to retin-A

I use that cream, but I use the 5,000 IU version; I like it as it keeps my skin looking nice and smooth. I'm 26 so I'm not sure if it's working but it's doing a good job of keeping my skin moisturized and dry free.

[HOTCells]

Anybody know of the best science-based anti-aging skin creams? I've heard of Geronova's Rejuv, LEF's Rejuvenight/Rejuvenex, and Revgenetics had a resveratrol-containing cream. What is the latest?

In my experince resveratrol does absolutely nothing for wrinkles. What I do find works is Tretinoin at night 0.05% and a good 17% vitaminc C serum (only ascorbic acid) followed by a good peptide enriched moisturizer (one that contains a multitude of peptides, i.e. Matrixyl, and Matrixyl 3000) in the morning. BTW, I never had any luck with LEF's skin care products. I am guessing this is because LEF doesn't use the recommended amount of matrixyl 3000 or other peptides in their products. I have e-mailed them asking them the percents they use, but they wouldn't tell me, stating that it was a "trade secret." When it comes to peptides, there really is no trade secret, either you use a percent that has been shown to be effective or you don't. I am only speculating that LEF's refusal to answer my question is because they don't.

Edited by HOTCells, 01 May 2011 - 06:47 PM.

[Justchill]

What about the nivea creams with CoQ10 enzyme; should that be beneficial ?

[tintinet]

Anybody know of the best science-based anti-aging skin creams? I've heard of Geronova's Rejuv, LEF's Rejuvenight/Rejuvenex, and Revgenetics had a resveratrol-containing cream. What is the latest?

In my experince resveratrol does absolutely nothing for wrinkles. What I do find works is Tretinoin at night 0.05% and a good 17% vitaminc C serum (only ascorbic acid) followed by a good peptide enriched moisturizer (one that contains a multitude of peptides, i.e. Matrixyl, and Matrixyl 3000) in the morning. BTW, I never had any luck with LEF's skin care products. I am guessing this is because LEF doesn't use the recommended amount of matrixyl 3000 or other peptides in their products. I have e-mailed them asking them the percents they use, but they wouldn't tell me, stating that it was a "trade secret." When it comes to peptides, there really is no trade secret, either you use a percent that has been shown to be effective or you don't. I am only speculating that LEF's refusal to answer my question is because they don't.

If LEF's peptide enriched products are not good, what are some good ones?

[tommix]

Maybe i will sound like caveman, but i think the best stuff to use is very cheap and very simple - take any butter, lets say cocoa butter, melt it, put there vitamin a palmitate, to get ~5000 iu/ml (mililiters), put vitamin e. Mix it, let it become solid - voila! it will cost not more 10$ for 200 grams! it will lasts like half a year for person! BEfore you use it - take a lemon, squeeze juices, use them on your face, be with them for 20 minutes, wash, and use that cream. You all know what vitamin a does for skin, what e and c does. It's nature baby! And you have to use that earlier you can, the earlier you start to use-the longer you'll save better skin DNR, not damaged by free radicals (which is the main reason for aging skin).

There is one site http://www.dermaxime.com/vitamin-a.htm where is many vitamin a palmitate effetcs on skin.

PS NEVER EVER use those commercial creams-they are SHIT! 99% of ingredients are for preservative purpose only, and milligram of stuff is for skin, so better - do it yourself with natural ingredients. Cause those companies-they don't give a shit about your skin. All their stuff not working, it only lats the same amount of time-until next "better" products will be created. [it's like Always -the same shit, but every few months there comes a better version of it]

And yes - telomeres have nothing to do with longevity. And if it does, which is not - who cares? It doesn't makes you look younger, it does not make your organs to be younger. It does not protects DNA from free radicals. Few years ago i was so into it, i was thinking-wow it's amazing.. but it's NOT. I have more faith, and more facts to back it up, in melatonin then in telomeres I respect Anthony_Loera - but man Blackburn worked on it almost 30 years.. you're waisting your time i think.

Edited by tommix, 04 May 2011 - 02:25 PM.

[noos]

tommix, thanks for posting your formula.
Does it has to be vit A palmitate or other form is ok?
Are you sure you can keep this mix without contamination problems? No preservatives?
Also, isn´t it too oily?
I was thinking in diluting in coconut oil which I think it is good for the tocotrienols.

Edited by noos, 24 September 2011 - 01:52 AM.

[Anthony_Loera]

And yes - telomeres have nothing to do with longevity. And if it does, which is not - who cares? It doesn't makes you look younger, it does not make your organs to be younger. It does not protects DNA from free radicals. Few years ago i was so into it, i was thinking-wow it's amazing.. but it's NOT. I have more faith, and more facts to back it up, in melatonin then in telomeres I respect Anthony_Loera - but man Blackburn worked on it almost 30 years.. you're waisting your time i think.

I will disagree with you on the question of telomeres. The main item that I took from Blackburn was that telomeres shrink at different rates, she also was not working on longevity with telomeres for 30 years. She was discovering and studying them, the function, repair and all the minutea regarding their function in cells. Without her discoveries and information, we could certainly not stand on the shoulders of this giant of science and suggest new ideas and new efforts. So I think you believe she was studying longevity through telomeres and telomerase, and I believe this thinking is wrong. Understanding how telemeres work was her principal goal, not using them to increase longevity.

Having said that, our current skin cream does not activate telomerase.

Instead the new formulation works through micronized resveratrol activating of SIRT1, the P53 gene, FOX01, and with the new addition of tetrahydrocurcumin and (a stabilized form of GHK) it now becomes a dramatically much more powerful gene activation skin cream. (a stabilized form of GHK) alone is shown to dramatically heal wounds in ulcers for patients with diabetes and I believe is a peptide that shuttles ingredients into cells:

http://onlinelibrary...99A08109.d02t01

Some background on GHK copper and wound healing in skin:
http://www.pedorthic...d%20Healing.pdf


Of course, we don't claim GHK in our cream is for wound healing as it's formulation is not specifically for open wounds at all (so don't try it), but suggest that it only helps repair skin along with other benefits that are associated with it.

Yes folks, this is a fantastic science based cream, using these and 3 other ingredients that have all been studied as well.

Cheers
A

Edited by Anthony_Loera, 24 September 2011 - 04:45 PM.

[mustardseed41]

Idebenone is far more proven to work topically than Resveratrol. In any case, both pail in comparison to Tretinoin (retin-a).

[Al-Iksir]

What about the nivea creams with CoQ10 enzyme; should that be beneficial ?

well, without the nivea the q10 would surely be beneficial
contains some bad stuff. keep it natural.

[Anthony_Loera]

Idebenone is far more proven to work topically than Resveratrol. In any case, both pail in comparison to Tretinoin (retin-a).

Do you have a study for that claim? I think I posted a study that says resveratrol is 17x better:
http://onlinelibrary...08.00354.x/full

A

[canz]

Life cell works well for me. South Beach Skin care. Advertisements are over the top, but the product actually works quite well.

[MrHappy]

I'm not sure exactly which item or combination of items in my current nootropic stack is the cause of it, but in the last 2 months my skin has gone from mid-30s appearance to mid-20s. It was unexpected, to say the least. The elasticity has improved dramatically and wrinkles have visibly shrunk or 'disappeared' - other than under my eyes.

[noos]

Have you posted your regimen MrHappy?

[mustardseed41]

Idebenone is far more proven to work topically than Resveratrol. In any case, both pail in comparison to Tretinoin (retin-a).

Do you have a study for that claim? I think I posted a study that says resveratrol is 17x better:
http://onlinelibrary...08.00354.x/full

A

You still actually believe that I see. Oh my. I can find you A (key letter A) study that say's just about anything. But then you got sumin to sell.

Edited by mustardseed41, 09 November 2011 - 09:17 PM.

[Anthony_Loera]

You still actually believe that I see. Oh my. I can find you A (key letter A) study that say's just about anything. But then you got sumin to sell.

Then it appears you are blind? I didn't know, I am sorry about that.

A

[MrHappy]

Have you posted your regimen MrHappy?

I did in the uridine thread.. is there a better place? Perhaps my status..?

My daily morning regime is:
500mg of alpha-gpc choline
250mg of uridine-5'-monophosphate
1 berocca
Washing down:
4 capsules of flaxseed oil (I'm vegetarian)
1 vitamin E capsule
1 grape-seed extract capsule equiv 12000mg

My nightly regime is:
1 lecithin capsule 1200mg
1 grape-seed extract capsule
1 sublingual B-12
Occasionally a bacopa capsule, 2 hours before sleep.

Could so many possiblities from that list... <chuckle>

[Methos000]

Have you posted your regimen MrHappy?

I did in the uridine thread.. is there a better place? Perhaps my status..?

My daily morning regime is:
500mg of alpha-gpc choline
250mg of uridine-5'-monophosphate
1 berocca
Washing down:
4 capsules of flaxseed oil (I'm vegetarian)
1 vitamin E capsule
1 grape-seed extract capsule equiv 12000mg

My nightly regime is:
1 lecithin capsule 1200mg
1 grape-seed extract capsule
1 sublingual B-12
Occasionally a bacopa capsule, 2 hours before sleep.

Could so many possiblities from that list... <chuckle>

What has changed here in the past two months?

[niner]

Idebenone is far more proven to work topically than Resveratrol. In any case, both pail in comparison to Tretinoin (retin-a).

Do you have a study for that claim? I think I posted a study that says resveratrol is 17x better:
http://onlinelibrary...08.00354.x/full

That study claims that resveratrol is 17x better as an antioxidant than idebenone, but that doesn't have much bearing on how well either of them work for skin. The actual mechanisms of action of both may involve things other than antioxidant properties. The ability of each to be delivered to the cell and to withstand metabolism are both critical factors, while the 17x figure is probably in vitro. I'm pretty sure that both compounds do pale in comparison to tretinoin, which has voluminous human clinical data. However, tretinoin has significant toxicities, and as far as I know topical resveratrol and idebenone do not.

[MrHappy]

All of it. I was on MB + ascorbic acid and friends before that.