2 replies to this topic

[treonsverdery]

Just a few hours ago I thought, Yo, they should give Royal jelly to a variety of bugs to make them have different shapes plus live longer. If it works perhaps it could work on people.

Fortunately someone thought of this first then published a paper about 2 months ago. Nature http://www.nature.co...ature10093.html describes using royal jelly diet on other species to see if it affects them. Drosophila, one of the longevity model bugs creates changes to a larger shape just like honeybees. The drosophila also go from living 55 days to 70 days. about 30 pt longer. (drosophila engineered to actually produce the royalactin protein lived 80 days or about 45 pt longer)

Note that Bees given Royal jelly live about ten times longer. years rather than months. The nature article notes that a single protein royalactin is the source of the morphology change

The article has a longevity graph which I used the browser zoom to view.

obviously trying out royalactin on yeast, c elegans as well as mice to find longevity effects would be of benefit. The effect on the hayflick effect at human tissue culture would also be wonderful to read about. Notably royalactin is similar at longevizing to resveratrol among drosophila yet perhaps uses a completely different genetic pathway.

Edited by treonsverdery, 26 June 2011 - 08:32 PM.

[treonsverdery]

So, this brings to mind the longevity process of multidecade old lobsters

[Simon Silver]

This thread is old, but this is relevant and interesting. A royal jelly experiment on mice was in fact conducted in 2003, and the high/intermediate daily dose mice had a 25% lifespan increase. I think I will be stocking up on this, there is an old thread on mindandmuscle neuroscience forum about royal jelly with a wealth of info. I wasn't so interested then, but I don't think the life extension properties had come to light then. Here is the study abstract:


Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage.
Inoue S, Koya-Miyata S, Ushio S, Iwaki K, Ikeda M, Kurimoto M.
Source

Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675-1 Fujisaki, Okayama 702-8006, Japan. fujisaki@hayashibara.co.jp
Abstract

In this study, we investigate the effect of dietary Royal Jelly (RJ) on tissue DNA oxidative damage and on the life span of C3H/HeJ mice. In C3H/HeJ mice that were fed a dietary supplement of RJ for 16 weeks, the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, were significantly reduced in kidney DNA and serum. Secondly, we determined the effect of dietary RJ on the life span in C3H/HeJ mice. The 50% mice survivals of intermediate- (about 6 mg/kg weight) and high-dose groups (about 60 mg/kg weight) were reached at significantly longer times than that of the control group according to the generalized Wilcoxon test (p<0.05). The average survival times were 88 weeks for the control group vs. 79 weeks for the low-dose group (about 0.6 mg/kg weight), 112 weeks for the intermediate-dose group and 110 weeks for the high-dose group, respectively, showing that RJ extended the average survival time by about 25% compared to the control group. However, RJ did not extend the total life span. These results indicated that dietary RJ increased the average life span of C3H/HeJ mice, possibly through the mechanism of reduced oxidative damage.
PMID: 12954483 [PubMed - indexed for MEDLINE]

EDIT: I found you can get a kg online for $100 shipped frozen. The mg to kg conversion gives me 500mg per day for the intermediate group, which would make this the cheapest life extension supplement ever, except for maybe Methylene Blue.

Edited by Simon Silver, 21 October 2012 - 06:08 AM.