1 reply to this topic

[brokenportal]

http://www.scripps.e...tabolism-aging/

Here is one quote from the page:

Multidisciplinary approaches create synergy in the discovery process. Areas of research include developmental biology of fat and muscle, cartilage catabolism, whole body metabolism, molecular genetics, bioinformatics, imaging, and structural studies on G-protein coupled receptors (GPCRs). The department also applies zebra fish and mouse genetics to help identify safe drug targets for treatment and prevention of functional deficiencies. Such approaches led to identification of a new GPCR, GHS-R1a, and its endogenous agonist, a hormone called ghrelin. A decline in ghrelin production appears to explain many of the changes occurring during normal aging.

I havent looked into this too much. Is there already aging research on the table in this way that we could be supporting?

[Logic]

Ghrelin seems to be produced by gut bacteria and signal the brain that you are hungry.
Leptin does the opposite and we tend to become more resistant to Leptin signalling from sugars and fructose.

We aren't what we eat; We are what our gut bacteria excrete.
Put another way: We're all living on bacteria shit! (Sung to the tune of Yellow Submarine)

So research on probiotics, prebiotics and how to get the right bacteria into the gut alive and keep them that way is what's called for here.

The research on FOS, Inulin, RS seems quite advanced while the research on bacteria types, what they excrete and novel bacteria like LKM-512 seems to be in its infancy and critical to health and longevity due to the wide ranging and dramatic effects they have.

I think novel bacteria can be found or made that would have profound effects on longevity by constantly producing beneficial substances.

Manipulating Host-Microbe Interactions: Probiotic Research and Regulations
http://www.ncbi.nlm....books/NBK57065/

http://www.emergingi...ing-probiotics/

http://pspg.ucsf.edu...-receives-young

http://www.uoguelph....en-vercoe.shtml