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Schizophrenia Related Cognitive Decline Help

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#1 max_cognition

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Posted 05 November 2011 - 06:08 AM


Hi,

I have schizophrenia and over the years my cognition has been declining. I don't know if it's because of the medications or the illness. For all I know it could be a mixture of both. I have memory problems (both short term and long term), problems concentrating, low attention span, trouble speaking and putting my thoughts into words, etc. The list goes on. Nevertheless, I'd like to correct my cognitive problems through the use of substances like nootropics and other smart drugs. I've talked to my psychiatrist about this and he doesn't seem to have a clue. "Just take your meds," he says!

I became interested in these substances after I saw the movie Limitless. In a way I'd like to find my own NZT!

I've been doing some research on this a have a list of various substances to try. I guess the only way to really know which works is through experimentation. So far I plan on buying the following substances from Cerebral Health:

-Piracetam (and maybe later other racetams like Oxi and Ani)
-Choline Bitartrate (or would Alpha-GPC work best?)
-Noopept (though I wouldn't use this regularly)
-Sulbutiamine (I'm thinking a of using this before exercising)

I've also thought about trying N-Acetyl-Tyrosine (or is it N-Acetyl L-Tyrosine?) and Hydergine and a few others which I have written down in my notes. To be honest I'd like to try it all but I know I should probably do it carefully. Maybe try one at a time and then maybe combine them for a synergistic effect.

Thanks for reading and feel free to comment. Thanks!

#2 Connor MacLeod

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Posted 05 November 2011 - 06:55 AM

You might want to have your homocysteine level checked. In addition to cardiovascular disease, elevated homocysteine is also associated with schizophrenia and other neurological disorders (e.g. depression, autism, Alzheimers, etc.) For example:

Plasma homocysteine, folate and B12 in chronic schizophrenia
http://www.sciencedi...278584607001844

Various supplements have proven effective at bringing down homocysteine levels, in particular folinic acid (probably better to avoid folic acid), B-12, TMG (trimethlyglycine), and B6. These nutrients play key roles in three metabolic reactions that recycle or process homocysteine.

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#3 Verne

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Posted 05 November 2011 - 02:14 PM

You know... Omega 3 Fish Oil might actually be of some help to you. I came across this today while reading up on it myself:

A study from the Orygen Research Centre in Melbourne suggests that omega-3 fatty acids could also help delay or prevent the onset of schizophrenia. The researchers enlisted 81 'high risk' young people aged 13 to 24 who had previously suffered brief hallucinations or delusions and gave half of them capsules of fish oil while the other half received fish-tasting dummy substitute. One year on, only three percent of those on fish oil had developed schizophrenia compared to 28 percent from those on the substitute. A study conducted at Sheffield University in England reported positive results with fish oil on patients suffering from schizophrenia. Dr. Malcolm Peet, Professor of Psychiatry at Sheffield University organized the study and followed the progress of the participants. Participants of the study were previously taking anti-psychotic prescription drugs but after some time were no longer effective on patients. After taking fish oil supplements, participants in the study experienced progress compared to others who were given a placebo.
However, the largest controlled study to date found no cognitive benefit after two years in the elderly.



http://en.wikipedia....l#Mental_health


#4 hippocampus

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Posted 05 November 2011 - 06:51 PM

try gluten-free diet for a month (google "gluten schizophrenia" for more info)
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#5 Application

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Posted 06 November 2011 - 03:53 AM

It might help if you posted your medications. But in general schizophrenia medications tend to be the opposite of smart drugs. They heavily suppress many of the neurotransmitters that nootropic users are seeking to raise such as dopamine and the cholinergic system.

Hi,

I have schizophrenia and over the years my cognition has been declining. I don't know if it's because of the medications or the illness. For all I know it could be a mixture of both. I have memory problems (both short term and long term), problems concentrating, low attention span, trouble speaking and putting my thoughts into words, etc. The list goes on. Nevertheless, I'd like to correct my cognitive problems through the use of substances like nootropics and other smart drugs. I've talked to my psychiatrist about this and he doesn't seem to have a clue. "Just take your meds," he says!.....


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#6 Luminosity

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Posted 06 November 2011 - 04:12 AM

Chinese medicine (herbs and acupuncture) can be used on mental illness. You would want to find a good acupuncturist. I wrote a thread on that you could look for. You would not want to smoke cigarettes, take recreational drugs, consume too much sugar, sodas caffeine or junk food. Eat fruits and veggies, and take care of yourself.

The difficulties you mentioned could be caused by your medications but I hesitate to even say that because of what could happen if you stop taking them. If you can find good magnesium and vitamin B6 supplements, those can help support your nervous system, as well as a general B vitamin supplement. If you don't get much sun and are deficient in vitamin D, a good supplement would help you feel better. Source Naturals is a good one.

Your post seems very lucid and intelligent.

Good luck.

Edited by Luminosity, 06 November 2011 - 04:13 AM.


#7 The Immortalist

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Posted 06 November 2011 - 04:54 AM

Hi,

I have schizophrenia and over the years my cognition has been declining. I don't know if it's because of the medications or the illness. For all I know it could be a mixture of both. I have memory problems (both short term and long term), problems concentrating, low attention span, trouble speaking and putting my thoughts into words, etc. The list goes on. Nevertheless, I'd like to correct my cognitive problems through the use of substances like nootropics and other smart drugs. I've talked to my psychiatrist about this and he doesn't seem to have a clue. "Just take your meds," he says!


What's it like having schizophrenia? Do you see illusions and other things that are not real? Do you hold beliefs that are contrary to reality? It doesn't really make sense to me how a person could be like that.
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#8 hippocampus

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Posted 06 November 2011 - 01:23 PM

there are many books about schizophrenia, read some ...

milk thistle can help against liver damage induced by antipsychotic medication.
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#9 max_cognition

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Posted 17 November 2011 - 06:17 AM

I tried to post a reply but it's not showing up...

#10 max_cognition

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Posted 17 November 2011 - 06:20 AM

You might want to have your homocysteine level checked. In addition to cardiovascular disease, elevated homocysteine is also associated with schizophrenia and other neurological disorders (e.g. depression, autism, Alzheimers, etc.) For example:

Plasma homocysteine, folate and B12 in chronic schizophrenia
http://www.sciencedi...278584607001844


I wasn't aware of that, thanks for telling me! I'll be sure to look it up.

I get regular (about once per year) urine and blood tests. Everything always comes out okay. No complains from my family doctor.

Various supplements have proven effective at bringing down homocysteine levels, in particular folinic acid (probably better to avoid folic acid), B-12, TMG (trimethlyglycine), and B6. These nutrients play key roles in three metabolic reactions that recycle or process homocysteine.


I used to take Super B Complex (Nature's Bounty) with Folic Acid plus Vitamin C and Biotin for a few weeks. I didn't really notice a difference.

Anyway, everyday I prepare myself a large bowl of fruits and vegetables, so I don't think I need extra vitamins and minerals. However, I do take a vitamin D supplement because I don't get much sun anymore.

You know... Omega 3 Fish Oil might actually be of some help to you. I came across this today while reading up on it myself:
Quote

A study from the Orygen Research Centre in Melbourne suggests that omega-3 fatty acids could also help delay or prevent the onset of schizophrenia. The researchers enlisted 81 'high risk' young people aged 13 to 24 who had previously suffered brief hallucinations or delusions and gave half of them capsules of fish oil while the other half received fish-tasting dummy substitute. One year on, only three percent of those on fish oil had developed schizophrenia compared to 28 percent from those on the substitute. A study conducted at Sheffield University in England reported positive results with fish oil on patients suffering from schizophrenia. Dr. Malcolm Peet, Professor of Psychiatry at Sheffield University organized the study and followed the progress of the participants. Participants of the study were previously taking anti-psychotic prescription drugs but after some time were no longer effective on patients. After taking fish oil supplements, participants in the study experienced progress compared to others who were given a placebo.
However, the largest controlled study to date found no cognitive benefit after two years in the elderly.


http://en.wikipedia....l#Mental_health


I used to take Fish Oil but didn't notice any perceivable benefits (I was only on it for about a month, though). I still have some left but I'm saving it for when I get some Piracetam. I've read somewhere that it's good to use these two together.

try gluten-free diet for a month (google "gluten schizophrenia" for more info)


I've heard about this but I've never tried it. Thanks for reminding me!

It might help if you posted your medications. But in general schizophrenia medications tend to be the opposite of smart drugs. They heavily suppress many of the neurotransmitters that nootropic users are seeking to raise such as dopamine and the cholinergic system.


I take 25 mg of Olanzapine (also known as Zyprexa). They prescirbe this dose up to 30 mg. I've also been on Risperdal, Seroquel and Geodon. I've been on meds for almost 3 years now. I'd like to be off them but they say this isn't possible without becoming psychotic again.

Chinese medicine (herbs and acupuncture) can be used on mental illness. You would want to find a good acupuncturist. I wrote a thread on that you could look for. You would not want to smoke cigarettes, take recreational drugs, consume too much sugar, sodas caffeine or junk food. Eat fruits and veggies, and take care of yourself.


My mum did mention a few times how her friend's son (who also has some type of mental disorder) has been helped by Chinese medicine. I'll do some research on this topic and I'll be sure to ask my pdoc about it, so thanks to you, too, Luminosity!

The difficulties you mentioned could be caused by your medications but I hesitate to even say that because of what could happen if you stop taking them. If you can find good magnesium and vitamin B6 supplements, those can help support your nervous system, as well as a general B vitamin supplement. If you don't get much sun and are deficient in vitamin D, a good supplement would help you feel better. Source Naturals is a good one.


I did go off my meds a few months ago but had to go back on after 3-4 weeks. It was like a reawakening of the senses at first but then it became too much to handle. I guess you could say I became psychotic.

Your post seems very lucid and intelligent.

Good luck.


Thank you very much! I'm pretty stable on my meds.

What's it like having schizophrenia? Do you see illusions and other things that are not real? Do you hold beliefs that are contrary to reality? It doesn't really make sense to me how a person could be like that.


How a person can be like what exactly? Schizophrenic? It's a brain illness, basically. Anyone can get sick. Sometimes it's torture and like being in a nightmare. But I'm human just like you and we can get used to just about anything.

It's not all bad. I suppose it does have its perks.

milk thistle can help against liver damage induced by antipsychotic medication.


Thanks!


You've all given me a lot to think about and do research on. I've written a lot of it down and I also plan on discussing it with my psychiatrist. So thanks for that. I'll be around for any further information. I should be getting my nootropics in a 2-3 weeks, so, if you like, I'll keep you posted on its effects etc.

#11 max_cognition

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Posted 17 November 2011 - 06:26 AM

Okay, I think I got it figured out. It wasn't posting because of the links, I think. Also, I quoted each one of you by name but for some reason it didn't go through... Please excuse. Thanks!

#12 chrono

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Posted 17 November 2011 - 06:51 AM

Okay, I think I got it figured out. It wasn't posting because of the links, I think. Also, I quoted each one of you by name but for some reason it didn't go through... Please excuse. Thanks!


Hi max! I approved your original post. For members with less than 10 posts, links need to be approved (keeps the spam-mongers away). There's usually a notice about this, but there have been some bugs lately, so maybe you didn't see it.

You do sound really lucid to be asking this type of question, so I think you're starting from a good place. I don't have a lot of knowledge about schizoaffective disorders, but I would suggest some more of the 'generally supportive' class of nootropics. Stuff like fish oil, green tea extract, phosphatidyl serine, etc. You probably won't 'feel' this kinda stuff in the same way as the nootropics in the first post, but they're a good idea for cognitive health in general, and if you're battling a disorder with real cognitive decline, giving your brain the nutrients it needs to function at its peak and avoid other kinds of degeneration is doubly important.

#13 Propoxy

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Posted 17 November 2011 - 06:12 PM

Glycine or Sarcosine

also if you feel sick in the morning and have white spots on your nails you should get yourself checked for pyroluria here a full list of symptoms http://www.naturopat...oluria_quiz.htm

http://www.ncbi.nlm....1?dopt=Abstract
http://www.ncbi.nlm....7?dopt=Abstract

Edited by Propoxy, 17 November 2011 - 06:17 PM.


#14 sam7777

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Posted 18 November 2011 - 02:44 AM

O wow, I would be highly amazed if such an oversight in a simple vitamin and mineral was all that was causing the problem, and yet hardly anyone ever gets basic mineral and vitamin tests sadly.

#15 medievil

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Posted 30 November 2011 - 12:04 AM

It might help if you posted your medications. But in general schizophrenia medications tend to be the opposite of smart drugs. They heavily suppress many of the neurotransmitters that nootropic users are seeking to raise such as dopamine and the cholinergic system.

Hi,

I have schizophrenia and over the years my cognition has been declining. I don't know if it's because of the medications or the illness. For all I know it could be a mixture of both. I have memory problems (both short term and long term), problems concentrating, low attention span, trouble speaking and putting my thoughts into words, etc. The list goes on. Nevertheless, I'd like to correct my cognitive problems through the use of substances like nootropics and other smart drugs. I've talked to my psychiatrist about this and he doesn't seem to have a clue. "Just take your meds," he says!.....

Im in the predromal phase and antipsychotics were cognitive improving for me. I have the most succes with methylene blue and nefiracetam, also arcosine and nac can help alot, both are effective for negative symptons, ive improved my declining cognition alot, also fish oil works to help prevent progressin into shizophrenia.

#16 medievil

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Posted 30 November 2011 - 12:08 AM

I compiled a extensive list of effective medications and supplements in this thread:
http://www.mindandmu...phrenic-regimen

#17 Adan

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Posted 01 December 2011 - 06:16 PM

I have schizophrenia and tried a number of nootropics. None of them helped and I am not sure why. I tried Oxiracetam, Aniracetam, CDP Choline, Lion's mane, fish oil, and sarcosine. I did experience a temporary improvement in my cognition the first time I tried Oxiracetam but I think it was a placebo effect. I think that's the case because after that first day I didn't experience any improvements.


There's one thing to note though, my psychiatrist increased my antipsychotic dose a couple of times during the time I tried these substances. So maybe they don't work after a certain antipsychotic dose is reached. I don't really remember the doses though. I'm currently at 5mg of risperidone per day.

Edited by Antonio, 01 December 2011 - 06:28 PM.


#18 Adan

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Posted 01 December 2011 - 11:21 PM

I came across this article today:

http://www.scienceda...10417214159.htm

A substance named L-Lysine may help alleviate schizophrenia symptoms - specifically cognitive deficits. I may try it.
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#19 Ark

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Posted 02 December 2011 - 12:18 AM

You may want to consider that your Schizophrenia is caused by Toxoplasmosis, a parasite transmitted through contact with cats.

If this is the case , I would think trying to up the immune system would help limit the effect of Toxoplasmosis ability to alter/affect the production of dopamine which is known to be linked to devolpment of Schizophrenia.
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#20 Adan

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Posted 03 December 2011 - 04:31 PM

Looks like a substance l-lysine might help with cognitive deficits and negative symptoms. The trial reported in the article was very small though so I wouldn't get too excited.

http://www.scienceda...10417214159.htm

#21 Adan

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Posted 03 December 2011 - 04:33 PM

oops, I forgot that links aren't allowed.

Anyway, a substance called l-lysine might help. A small trial on it for schizophrenia was reported on that website science daily. Specifically it helped with cognition and negative symptoms in some patients. I might try it.

Edited by Antonio, 03 December 2011 - 04:35 PM.


#22 medievil

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Posted 05 December 2011 - 06:28 PM

oops, I forgot that links aren't allowed.

Anyway, a substance called l-lysine might help. A small trial on it for schizophrenia was reported on that website science daily. Specifically it helped with cognition and negative symptoms in some patients. I might try it.

Yes it seems to have some potential, it acts by depleting iNOS wich has negative effects, overall eNOS seems to be good in shizophrenia, besides nmda agonists resveratrol and ginseng increase eNOS activity.

Here's a list of other endogenious nutrients that have shown effiacy.


Acetylcysteine
Sarcosine
DHEA
Pregnenolone
Vitamin B12
L methylfolate

Theoretical:
Alcar
D aspartic acid

Besides that we have minocycline, mirtazepine, buspar and other meds with positive trials when added to a antipsychotic.

Edited by medievil, 05 December 2011 - 06:28 PM.


#23 thedevinroy

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Posted 05 December 2011 - 09:31 PM

Olanzapine seems to block dopamine, serotonin, muscarinic, histamine, and adrenergic receptors. Nicotinic receptors are unaffected. Thus, I suggest something that increases Nicotinic Receptor density and/or stimulation such as Noopept, ALCAR, Alpha GPC, Lemon Balm, or Galantamine. CDP Choline would contradict your medication. I'd start with Alpha GPC, since it is also a powerful methyl donor. Add in a racetam if needed, and if Alpha GPC doesn't help, experiement with co-administration of ALCAR doses from 250mg to 2 grams.

As far as herbs for Schizophrenia, a combination of various sedatives and adaptogens, possibly nervines and tonics. I'd start with Chamomile and Gotu Kola. Add in Ashwagandha and Ginkgo when needed for a boost. Lemon Balm when you need to relax and introspect.

You ever try Picamilon? Chronic B3 supplementation has helped schizophrenia in experiments... temporarily cured it actually. (Look up the study by Dr. Humphrey Osmond and Dr. Abram Hoffer in 1951.) Picamilon has GABA attached to B3, to easily cross the BBB. It may be sedating, so I don't like taking more than 25-50mg at a time. You might be able to handle more.

Lastly, Schizophrenia may in fact be caused by the parasitic virus, Toxoplasmosis, as Ark mentioned. Many immunostimulants may provide some relief. Ashwagandha also increases cholinergic activity, so that one's a double whammy for you (though it also stabilizes monoamines, which as long as you don't overdo it, won't cause problems with your medicine). Jiaogulan also looks pretty promising, too, and I am considering adding that to my own stacks. Other common herbs for stimulating the immune system (that will not contradict your medication) are Reishi, Garlic, Maitake, Noni, Echinacea, Astragulus, and Andrographis. Hell, any herbs would most likely give you an immune boost. No one gets enough green things...

Good luck!

#24 medievil

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Posted 05 December 2011 - 09:39 PM

I disagree that cdp choline would be bad, muscarinic antagonism can mostly been seen as undesirable in shizophrenia, counteracting the effects of antagonism may be a good idea. Altough antimuscarinics work in a study for sa, anhedonia and avolition they increase positive symptons and are bad for cognition.

#25 thedevinroy

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Posted 05 December 2011 - 10:43 PM

I disagree that cdp choline would be bad, muscarinic antagonism can mostly been seen as undesirable in shizophrenia, counteracting the effects of antagonism may be a good idea. Altough antimuscarinics work in a study for sa, anhedonia and avolition they increase positive symptons and are bad for cognition.


CDP choline increases dopamine receptor density (http://www.ncbi.nlm....les/PMC1908237/). Thus, it would counteract the antidopaminergic properties of Zyprexa to some degree. It's just as expensive as Alpha GPC, which provides the same other benefits on the cholinergic system. It would suck to find out CDP Choline increases schizophrenic symptoms after paying a pretty penny for it. Uridine also increases Potassium dependent dopamine release in the stratium (http://www.ncbi.nlm....pubmed/16055952).

Acetylcholine does to some degree increase dopamine receptor density, but only when both nicotinic and muscarinic receptors are stimulated at the same time. (http://www.ncbi.nlm....pubmed/15249143)

#26 medievil

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Posted 05 December 2011 - 10:57 PM

That may not allways be a bad thing, shizophrenics have low phasic dopamine levels wich is why amphetamine is an excellent treatment for negative symptons combined with a antipsychotic, also when D2 is sufficiently blocked, increased dopamine receptor density wont really overpower it, while it can potentiate D1 agonism, the most important in shizophrenia and D2/D3 at phasic level atleast to counteract ADHD and anhedonia and other negative issues.

Dopamine also causes NMDA antagonism in the prefrontal cortex i beleive this is mediated by D2, the glutamate system is at the core of shizophrenia, with dopamine, NE, nitric oxide, inflammation, oxidative stress, serotonine as secondary issues.
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#27 medievil

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Posted 06 December 2011 - 02:01 AM

Highly underrated l methylfolate.

My regime is gonna look like this:

Lexapro
Mirtazepine
Ritalin ER
FIsh oil
L methylfolate
DHEA
Methylene blue (may leave this out for a while to keep things minimal, even tough i definatly love this stuff, substances that can show structural or epigenetic changes after a few weeks are more important.)

Edited by medievil, 06 December 2011 - 02:03 AM.

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#28 MrHappy

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Posted 06 December 2011 - 09:05 AM

I'm truly sorry to be sounding like a broken record these days, but I think it's probably worth it, under the circumstances :) :

Uridine in schizophrenia & bipolar:
http://www.ncbi.nlm....pubmed/20504471
http://www.sciencedi...006899394906971
http://www.sciencedi...165614799012985
http://psycnet.apa.o...s/pha/16/3/199/
http://www.faqs.org/...app/20090054370
http://www.lieberton...9/cap.2010.0054
http://www.wikinvest..._(RGEN)/Uridine

Glutathione deficiency and schizophrenia:
http://www.ncbi.nlm....pubmed/16410648
http://www.ncbi.nlm....pubmed/20633320
http://www.ncbi.nlm....pubmed/20596963

Uridine in preventing apoptosis from glutathione deficiency:
http://www.ncbi.nlm....pubmed/16839635


B3 also shows some major promise according to a recently published paper (full paper reproduced in the link below):
http://www.regainmentalhealth.com/

#29 thedevinroy

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Posted 06 December 2011 - 04:52 PM

That may not allways be a bad thing, shizophrenics have low phasic dopamine levels wich is why amphetamine is an excellent treatment for negative symptons combined with a antipsychotic, also when D2 is sufficiently blocked, increased dopamine receptor density wont really overpower it, while it can potentiate D1 agonism, the most important in shizophrenia and D2/D3 at phasic level atleast to counteract ADHD and anhedonia and other negative issues.

Dopamine also causes NMDA antagonism in the prefrontal cortex i beleive this is mediated by D2, the glutamate system is at the core of shizophrenia, with dopamine, NE, nitric oxide, inflammation, oxidative stress, serotonine as secondary issues.


Phasic dopamine response in Schizophrenia: http://www.ncbi.nlm..../pubmed/1676137 Basically it says that tonic levels of dopamine create an abnormally high response to phasic dopamine release. How does this correlate to what you are saying?


NMDA antagonism is mediated also by D4 as well.

Perhaps Huperzine A would be a fair adjacent treatment, since it does increase NE and DA in the cortex as well as increase nicotinic receptor activity and directly antagonize NMDA receptors. You would obviously have to use it alongside a methyl donor to boost immunity and prevent subsequent depressive symptoms from sustained choline in the CNS (choline being an important methyl donor). Methylfolate is a good one.

Have yall ever tried Abilify? They are prescribing that stuff for everything nowadays... It's a D2 partial agonist (kind of like Chaste Berry in a way) and 5-HT2C partial agonist.

Edited by devinthayer, 06 December 2011 - 05:01 PM.


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#30 medievil

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Posted 06 December 2011 - 05:11 PM

In shizoprhenia you want to do the following:

Reduce tonic dopamine (ideally 5HT2C agonism, wich doesnt not interact with phasic dopamine levels)
Increase phasic dopamine, ritalin or amphetamine can only do this. Ritalin works good with lexapro and mirtazepine.

Antagonize several serotonine receptors, again 5HT2C antagonism and 5HT2A antagonism isnt ideal, but does shift dopamine balance away from the mesolimbic area's were tonic dopamine is pro psychotic

Increase NE while antagonizing alpha 2 (like with wellbutrin) i do not take a antipsychotic atm as i find mirtazepine does the job well enough, it synergizes with ritalins ne increase due to the alpha2 antagonism, also this increases 5HT, while 5HT1A is open the baseline serotonine + the released serotonin gets targetted to 5HT1A, this increases prefrontal dopamine levels wich counteracts pfc hypofunctioning in shizophrenia.

Most important as glutamate is at the core of shizophrenia, counteract the glutamate hypoactivity, agents that do this: minocycline, NAC, sarcosine, d aspartic acid, glycine and d serine (last are also glycine site agonists, sarcosine is one too while inhibiting reuptake of glycine. Besides NMDA are the other glutamate receptors highly important as well.
Pregnenoline and DHEA (preg is much better)potently modulate glutamate, dopamine and serotonin, preg is highly effective for both positive and negative symptons.

Deplete iNOS with l-lysine or minocycline wich as well modulates glutamate, minocycline is highly effective for negative symptons, sarcosine likewise.
Increase eNOS, both resveratrol and l methylfolate do this, mfolate is way more potent and also potently acts on methylation and epigenetics, extremely important for long term improvement.

I looked at every proven effective treatment for shizophrenia and i conclude to look no further than (http://www.mindandmu...phrenic-regimen)

Mirtazepine, NAC, glycine, sarcosine, d aspartic acid, aniracetam or nefiracetam, pramiracetam (it increases NO), L lysine, minocycline, DHEA, pregnenolone, l methylfolate, resveratrol, curcumin. If positive symptons a antipsychotictive but those cause long term brain damage and possible permanent movement disorders.

Personally im into predromal shizophrenia, a yearlong lasting phase to shizophrenia, however i am higly convinced damage can be reversed before a true unprovoked psychosis occurs.

Edited by medievil, 06 December 2011 - 05:17 PM.

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