Rapid version
Doubling the size of a nucleus creates 4 to 8 or more times as much chemical activity
Big nucleus Lotta chemistry, lotta metabolism, more rapid protein production
Little nucleus Less activity, "cooler thus longer lasting", CRmimetic?, fewer free radicals right where the DNA is?
Does changing the size of the nucleus effect longevity
Wordy version
Doubling the diameter of a nucleus makes the volume 8 times larger as well as makes the surface area 4 times larger (comparing diameter 2 or 4). This effects the activity area strongly, thus the amount of chemical activity. giving higher cytokine, nutrient movement, as well as free radical activity. Note however thaty big nucleus, like a big bowl of soup, might change less from outside the nucleus material transport. When observing tissues from the same organism are there cytes with different sized nuclei? If there are, do the smaller ones show different hayflick effect, free radical responsiveness, or DNA change rate, or CRmimetic protein making differences that go with 4 or 8 times different chemosurroundings. Does IPMAT (mitosis) effect nucleus size, if it does then the resize the nucleus to little cytokines may be new longevity drugs.
Well, with different sized nuclei effecting these parameters what is the effect of using the cytochemicals or genes that causes nucleus size variance on different tissue types. Will myocytes live 20 times longer if they have the same nucleus size as neurons (remember nonneurons get full replacement every 7 years, thus 140 year (multicentury with fish or turtles) neuron chemistry on all the other cyte types may give longevity) Further, is merely regulating mitosis to change the volume during IPMAT a way to increase longevity (light similarity to SENS)
Aside from siRNA to cytokine production pubmed lists a number of genes as well as chemicals that effect nucleus size change. Are there current drugs or plant chemicals that effect the nucleus size of regenerating tissue?
Also nifty
Does the nuclear envelope, like the dura or blood brain barrier, screen ick from the nucleus, if it does it then nuclear envelope genes may be a longevity membrane gene as better screening of things that reach the nucleus could be beneficial
Edited by treonsverdery, 10 January 2012 - 07:04 PM.
