13 replies to this topic

[InquilineKea]

I'm not sure if I can video-record the stuff, but I've tape-recorded a few sessions if anyone else wants to listen in.

[niner]

Anything interesting that we should know about?

[InquilineKea]

Yes - lots. We're discussing a huge number of research papers. The URL is here: http://bit.ly/wRhlTr

[AgeVivo]

research papers. The URL is here: http://bit.ly/wRhlTr

sounds very interesting

[chillywings]

Thanks for sharing! I'm definitely interested on listening in. Please post what you have if you'd be so kind.

[Mind]

Thanks for sharing. What I would be interested in is if you hear anything that has not been covered here in the forums. Something new or different that has not been discussed. I don't know how familiar you are with the discussions here, but pretty much every aging theory has been hashed over several times over the last decade. What I would like to hear about is new papers that shed some interesting light on some of these theories, or cast the problem in a slightly different light.

[Danail Bulgaria]

Thnaks for shareing them InquilineKea! Where can we listen to the sound files?

[InquilineKea]

I'll try to upload them at the end of the quarter (when the course ends).

[scottknl]

InquillineKea, What's the most surprising thing you've learned from this course so far? The topics look like lots of fun.

[InquilineKea]

Hm, probably the connection between deficient DNA repair and aging (there's a huge one - older people have more mutations and less efficient DNA repair), and the very numerous types of deficient DNA repair.

Also, aging does not affect neuronal transmission speed in mice, but it does make it harder to express the proteins used in the second step of long-term potentiation (which probably explains why fluid IQ decreases with age but also why crystallized IQ doesn't decline).

Also, the progerin protein does accumulate (in small amounts) in all people too (something that Aubrey de Gray missed).

Edited by InquilineKea, 05 February 2012 - 02:50 AM.

[scottknl]

Hm, probably the connection between deficient DNA repair and aging (there's a huge one - older people have more mutations and less efficient DNA repair), and the very numerous types of deficient DNA repair.

Also, aging does not affect neuronal transmission speed in mice, but it does make it harder to express the proteins used in the second step of long-term potentiation (which probably explains why fluid IQ decreases with age but also why crystallized IQ doesn't decline).

Also, the progerin protein does accumulate (in small amounts) in all people too (something that Aubrey de Gray missed).

I knew about the first one, and the second one matches experience. The progerin protein could be one of several mechanisms why ageing seems to gather speed as one gets older. It really does go faster, and it's not just perception. cool!

One factor of ageing I didn't know about until recently is that the environment your stem cells function in determines whether they differentiate or not. No differentiation = no cell replacement after apoptosis. CR is one way to keep your internal environment cleaner, I'd guess. Hopefully SENS will provide more at some future date.

[InquilineKea]

Oh yes - that too. The distinction between senescence and apoptosis is one that I learned a lot about in this course.

PS: Scott - since you're in Seattle, you can attend the course too! It's every Friday at 2:30 to 4:30 PM. Matt Kaeberlein is far nicer and far more open than most university faculty.

I'm not even registered for the course, but he still allows me to participate and to even do the assignments.

Edited by InquilineKea, 05 February 2012 - 08:33 PM.

[Musli]

Aubrey does know about progerin. According to him, it accumulates too slowly to contribute to the aging process as we know it today. Maybe when we get to the far longer lifespans, its accumulation will start affecting our health, but we shouldn't be concerned with it now.

As far as DNA mutations are concerned, Aubrey believes that (apart from mutations to mitochondrial DNA) they too do not contribute to aging within a normal (current) lifespan. And, so far, the research done by Dr Vijg's lab has not proven Aubrey wrong. Let's hope it stays that way and cancer is the only malignant condition resulting from DNA mutations.

Edited by Musli, 05 February 2012 - 10:36 PM.

[drew_ab]

Dr. Matt Kaeberlein recently wrote an article for Scientific American called:

"A Practical Approach to Healthspan Medicine" - Some forward-thinking physicicans are forging a new protocol for keeping their patients healthy as they age. 

 

https://www.scientif...hspan-medicine/

Edited by drew_ab, 16 April 2025 - 10:53 AM.