I had DP/DR really, really, really badly. I could not talk to people or make eye contact. Any anxiety causing situation: figure of authority, parent, friend, having to talk to strangers, forgetting something important, etc, would all trigger it: I would become numb all over my body, my head would feel weird and out of place. My vision would subtly change. Everything would look and feel very dream like. I would not be able to think or talk normally.. just completely derealized and depersonalized. I had tried many different things in my high school years, and nothing could help it. I could get temporary relief by drinking, but it would not actually make the DP/DR go away, it would just let me forget it. I meditated all the time and was really into lucid dreaming and astral projection. When I felt DP/DR symptoms I would feel like I was astral projecting or dreaming, although the DP/DR certainly came first. It came far before any spiritual experimentation. I had tried aniracetam and choline bit. and they definitely helped but they did not eliminate the symptoms. I would get very occasional 'glimpses' of a more normal, solid feeling existense where I actually felt like I inhabited my environment.
I began SSRIs, mainly Zoloft but also Prozac and Lexapro. These helped numb my emotions and made me indifferent to DP/DR sensations but they were still very much present. After withdrawing from Quite a few months ago, I completely and finally withdrew from Zoloft, and my symptoms came back with a vengeance, as if they had intensified twenty fold. It was awful, but I overcame it with the help of a lot of noots and supplements. Bacopa, taurine, noopept, aniracetam, alpha-GPC, sulbutiamine, theanine all did a great part in helping. But sarcosine was the only thing that ever consistently helped the DP/DR, which makes sense seeing as it pretty much has the opposite effect of a dissociative. The other noots helped with anxiety but the DP/DR came back when I stopped sarcosine. I currently do not take it, and I still feel DP/DR all the time with occasional 'glimpses' of normality, but the other noots/supps I take dilute the anxiety enough to where I do not stress about it. Also sarcosine has some strange interactions and probably should be cycled, but still IME it's the only thing that consistently makes me feel "associated" with reality. I'm sure other NMDA-modulating noots have potential in this field, but some of them are not very well studied and I am hesitant to try them.
TL;DR: DP/DR sucks, but sarcosine helps.
edit: spelling
Edited by katuskoti, 09 June 2014 - 03:57 AM.