My last updates
medievil 14 Apr 2012
I also reduced my regime to pregnenolone and a stimulant today because of a drastic reduction in ocd and me thinking logically (more sups just inhibit eachother.
My biggest help was l methylfolate wich theoretically can cure shizophrenia by silencing bad genes (silenced bad genes is why not all idential twins get shizophrenia if their sis/bro has it) it really did seem to have cured shizophrenia altough i bet alot of my other sups togheter with chronic social exposure helped me a shitload too.
I still need a stimulant; stimulants are EXTREMELY effective for negatives in shizo but should only be used in combination with something for positive symptions (id recommend methylene blue; pregnenolone; l methylfolate; nefiracetam mostly; one of those with amphetamine; i highly urge to avoid ap's).
Here's some good info on amp for shizo:
http://www.shire.com...hirenews?id=477
If anyone wants help with shizophrenia or has questions let me know; ill be glad to help.
malden 16 Apr 2012
interested in methylfolate, i think order some one.
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medievil 11 May 2012
Im taking
Lexapro
nac
Aniracetam
Cod liver oil
Glutamine
MPA
I take nac as a general health supplement and for tolerance (it can work for that as it slows glutaminergic firing; something for tolerance is important as aniracetam probably accelerates this). I take aniracetam as it could help my negative shizophrenia symptions due to its glutaminergic action; it also synergizes with stimulants; i add cod liver oil and glutamine to it to enhance its effectiveness. I take lexapro to augment the anti sa effect of stims and for my OCD. Mpa is currently take as stimulant as getting them prescribed in the uk is damn hard; but i want to replace it with ritalin ER.
Every few weeks i change regime somewhat and see what it does; so far im very pleased with the results;ill give it some time and report back in detail.
no idea whats up with the font...
Edited by medievil, 11 May 2012 - 04:14 PM.
malden 11 May 2012
I have the same aprouch as you, trieing different regimens every week or month, things like aniracetam and NAC have earned a definitif place in regimens. stuff seems to keep working for me.
Greetings
medievil 11 May 2012
Edited by medievil, 11 May 2012 - 11:16 PM.
medievil 11 May 2012
medievil 11 May 2012
malden 12 May 2012
lol insane regimes togheter with switching regime daily is a typical shizophrenia symption; it didnt make any sense whatsoever.
I think it do make sense, especialy if you keep shelter under shizophrenia. Acknowledge your symptons and try to balance them out is a good thing al will have more profits in the long run. I mean this only on prospect to regimens(. I can according to your info on the forum not judge the rest of your life naturally P)
Hold or switching to fast or to big regimens maybe a "Symptom" but ist something you can change if you want.
Ive had the same problem, but since I pridicted myself to hold on not take to much different things ive get a fat better point of what realy helps end what realy do not. plus it gives me more structure
just trieing to give some good advice here no hatings or whatever
Greetings
medievil 12 May 2012
My cognition was pretty damn impaired; i used to take big stacks before i triggered my progression allmost 2 years ago; but they were consisten after my cognition declined it got a ton worse so im pretty sure its involved.Hold or switching to fast or to big regimens maybe a "Symptom" but ist something you can change if you want.
Altough id agree its hard to blame shizophrenia for this; its not really a delusion.
Sure thing i appreciate all opinions/advice.
Edited by medievil, 12 May 2012 - 07:17 AM.
medievil 12 May 2012
medievil 12 May 2012
Psychopharmacology (Berl).
2011 Aug;216(4):589-99. Epub 2011 Mar 22.
Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors.
Yamada N, Araki H, Yoshimura H.
Source
Department of Pharmacology and Pharmacy, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Abstract
RATIONALE:
After reports of adverse effects with hormone replacement therapy, such as reproductive and breast cancer and coronary heart disease, much attention has been given to the development of new remedies to alleviate menopausal depression in women, but methods for their preclinical evaluation have not been clarified. We previously developed a procedure to predict the drug effect on the menopausal depressive-like state in female mice.
OBJECTIVES:
We attempted to identify psychoactive components from ginseng root, one of the earliest known materials for menopausal disorder, and to clarify the possible mechanism involved.
METHODS:
As an index of a depressive-like state, we used the prolongation of immobility time induced by an ovariectomy during the forced swimming test. Chronic treatment with the candidate substance began the day after ovariectomy and continued for 14 days. To examine whether the 5-HT(2A) receptor antagonist ritanserin antagonized the antidepressant-like effect of ginsenoside Rb(1), ritanserin was given as pretreatment 15 min before the daily administration of ginsenoside Rb(1) and the antagonistic effect was compared with ginsenoside Rb(1) alone.
RESULTS:
Ginsenoside Rb(1) and compound K were active ingredients that dose-dependently prevented the prolongation of immobility time induced by ovariectomy. Co-administration of ritanserin, a 5-HT(2A)-receptor antagonist, antagonized the effect of ginsenoside Rb(1).
CONCLUSIONS:
We suggest that ginsenoside Rb(1) and its metabolite, compound K, are antidepressant-like components of the ginseng root, and that 5-HT(2A) receptors may play an important role in mediating the antidepressant-like effect of ginsenoside Rb(1).
Eur J Pharmacol.
2001 May 18;420(1):33-43.
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Nakamura K, Kurasawa M.
Source
CNS Supporting Laboratory, Nippon Roche Research Center, 200 Kajiwara, Kamakura, 247-8530, Kanagawa, Japan. kazuo.nakmura@roche.com
Abstract
The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety. This study, therefore, aimed to characterize the anxiolytic effects of aniracetam in different anxiety models using mice and to examine the mode of action. In a social interaction test in which all classes (serotonergic, cholinergic and dopaminergic) of compounds were effective, aniracetam (10-100 mg/kg) increased total social interaction scores (time and frequency), and the increase in the total social interaction time mainly reflected an increase in trunk sniffing and following. The anxiolytic effects were completely blocked by haloperidol and nearly completely by mecamylamine or ketanserin, suggesting an involvement of nicotinic acetylcholine, 5-HT2A and dopamine D2 receptors in the anxiolytic mechanism. Aniracetam also showed anti-anxiety effects in two other anxiety models (elevated plus-maze and conditioned fear stress tests), whereas diazepam as a positive control was anxiolytic only in the elevated plus-maze and social interaction tests. The anxiolytic effects of aniracetam in each model were mimicked by different metabolites (i.e., p-anisic acid in the elevated plus-maze test) or specific combinations of metabolites. These results indicate that aniracetam possesses a wide range of anxiolytic properties, which may be mediated by an interaction between cholinergic, dopaminergic and serotonergic systems. Thus, our findings suggest the potential usefulness of aniracetam against various types of anxiety-related disorders and social failure/impairments.
Lexapro also provides additio
nal 5HT2A agonism wich is respond very well too (also explains my very good response to 5HT2A but all compounds have many other actions too).
With standard ad augmentation mostly being 5HT antagonists both compounds offer a novel alternative.
medievil 15 Jun 2012
Will take this till i receive the cilltep stack.
Also want to give papaverine a little try added to my stack.
medievil 15 Jun 2012
medievil 15 Jun 2012
medievil 15 Jun 2012
medievil 18 Jul 2012
Quercetin
Forskolin
Craze
D aspartic acid
Phenibut
Magnesium
Is my current combo, works pretty well except that i got a tremor of craze and some cafeine like anxiety wich is rather anoying.
medievil 27 Jul 2012
Currently im out of stims for a while but ill see how it goes, not sure what to do about anhedonia tough.
Also ran out of d aspartic acid, added some gotu kola instead of that wich also reases cAMP and should synergize with cilltep (curcumin is also a PDE4i like quercetin.
medievil 01 Aug 2012
Also gonna withdrawal of phenibut with benzo's as it barely helps anything, started taking it again for anhedonia several weeks ago but it only helped for 20% or so, barely at all actually.
St johns wort (perika)
Curcumin
Fish oil
DHEA
L methylfolate
Gotu kola
Is my current stack, i want to retry craze for a bit for anhedonia and motivational issues, this time with some benzo's around as last time it made me shakey and anxious at even the recommened doses, it didnt really work out that way as i kept taking more trying to overwrite the anxiety (it does help because the euphoria overpowers the anxiety but thats not a proper solution).
It all needs some time to work, hopefully st johns wort or dhea would help my anhedonia long term (beleive they both could help with that) but ill see.
Edited by medievil, 01 August 2012 - 01:31 PM.
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medievil 03 Aug 2012
With etizolam craze's works far better without the issues i had last time, works well for anhedonia, sa, motivation and focus.
I also replaced perika with aniracetam, i started getting sunburns alot so i stopped perika for now