• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

- - - - -

Allotopic Expression & the "Mitochondrial Problem"


  • Please log in to reply
93 replies to this topic
⌛⇒ support MITOMOUSE via LongeCity!

#91 John Schloendorn

  • Guest, Advisor, Guardian
  • 2,542 posts
  • 156
  • Location:Mountain View, CA

Posted 21 October 2006 - 08:35 PM

My point was simply that solving the mtDNA mutations problem would not necessarily make the other "deadly things" of SENS much easier.

I agree. This is why we differentiate between seven relevant classes of damage after all.

#92 Mark Hamalainen

  • Guest
  • 564 posts
  • 0
  • Location:San Francisco Bay Area
  • NO

Posted 21 October 2006 - 08:53 PM

Do I suffer from brain blockage or am I right in thinking that this decline cannot be a result of "mitochondriogenic" damage?


You're attacking a straw man. Nobody claims that allotopic expression will eliminate aging of the mitochondria entirely.

However, there is no research that I am aware of that seeks to design an intervention to address the age related depletion of the stem cell niche.


Thats a fairly obvious experiment Prometheus, and I will be happy to see it attempted, especially with some SENS modifications included in the new stem cells. Stem cell research does not lack for funding though, and I imagine this experiment will be attempted soon with or without the MF's help.

#93

  • Lurker
  • 1

Posted 22 October 2006 - 02:42 AM

SENS modifications included in the new stem cells

Such as?

⌛⇒ support MITOMOUSE via LongeCity!

#94 Mark Hamalainen

  • Guest
  • 564 posts
  • 0
  • Location:San Francisco Bay Area
  • NO

Posted 22 October 2006 - 10:08 PM

Such as?


I'll provide the allotopically expressed mitochondrial genes. John'll hook us up with the genes for some enhanced lysosomal enzymes. Just give us 3-4 years.




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users