Ladasten/Bromantan
@now 15 Sep 2012
Heraclitean 15 Sep 2012
Let's hope we get some answers, I do believe that a few people on this forum have taken it.
@now 15 Sep 2012
@now 15 Sep 2012
And of course: are there side effects, what are they, ... And is there desensitization.
Phenylpiracetam works fine for me, but if I read the logs that can change easily (that's why I never take it more than 1 time/week. Ever).
But if others tried Ladasten/Bromantan, I hope they share their experience.
@now 15 Sep 2012
Otoh it is an amantadine derivative..
Edited by @now, 15 September 2012 - 08:00 PM.
golden1 15 Sep 2012
S3B 16 Sep 2012
I have some friends from Russia who have managed to get me Noopept, Fenotropil (phenylpiracetam) and Ladasten too. Should take about a month to reach me as they have to send it via a friend travelling to London. Once I get Ladasten I'd be happy to post my experience with it. I am a noot-noob and I will start my Geratam (piracetam) + choline regime this coming week, and then stack the Noopept and Fenotropil when it arrives. This will also give me a good opportunity to log the differences in potency.
What interests me most is if Ladasten would be synergistic with the racetams. How should I stack it with my racetam regime. Any ideas? Let me know your thoughts, and I'll report back with my experience with Ladasten when I get it.
@now 17 Sep 2012
S3B 17 Sep 2012
I would try to test fenotropil and ladasten "stand-alone". That way you'll know better what the benefits are. More importantly, you'll notice any side-effects much better.
@now 22 Sep 2012
Details:
- took 50mg in the morning
- kicked in after 2h
- notably stimulating and anxiolitic
- better mood
- No noticable side effects
I think of it as anti-lethargy++ : you do all the little things without getting tired. No brain fog either. The difference compared to noopept is that you won't think "better" (but "more" - just better perserverance).
So if you're smart enough you'll get focus+++. I can also see how this will lift people out of a foggy/lethargic period: the stuff kicks in in 2h and lasts all day. Use that energy to change your habits and focus, keep at it some time, continue living without ladasten (my theory being that after a few weeks you get used to a different rythm)
I do think the dose of 50mg in the AM is enough given the half life of 11h AND you need to good care of yourself given that you'll burn more energy. Anyway, it definitely battles something that lot of people "fight".
Climactic 22 Sep 2012
Got some. Tried it. Basically a "boring" log: works as "advertised". Either there is a serious side effect - or it is very strange something like this isn't available in the west.
Details:
- took 50mg in the morning
- kicked in after 2h
- notably stimulating and anxiolitic
- better mood
- No noticable side effects
I think of it as anti-lethargy++ : you do all the little things without getting tired. No brain fog either. The difference compared to noopept is that you won't think "better" (but "more" - just better perserverance).
So if you're smart enough you'll get focus+++. I can also see how this will lift people out of a foggy/lethargic period: the stuff kicks in in 2h and lasts all day. Use that energy to change your habits and focus, keep at it some time, continue living without ladasten (my theory being that after a few weeks you get used to a different rythm)
I do think the dose of 50mg in the AM is enough given the half life of 11h AND you need to good care of yourself given that you'll burn more energy. Anyway, it definitely battles something that lot of people "fight".
Good log, but I think much more experience is warranted. I had the same effect, although the stimulation was admittedly mild. The next day I couldn't get the same effect even out of 100mg, and had to fallback to other stimulants. It stabilized my mood, but didn't make me feel any better than just fine. Rat studies have used much higher doses. For me, it remains to be seen whether it has an effect on physical endurance during a workout. In any event, it is too expensive at awakebrain.com, and much more so when trying higher doses..
Edited by Climactic, 22 September 2012 - 04:20 PM.
jerichodotm 23 Sep 2012
Got some. Tried it. Basically a "boring" log: works as "advertised". Either there is a serious side effect - or it is very strange something like this isn't available in the west.
Details:
- took 50mg in the morning
- kicked in after 2h
- notably stimulating and anxiolitic
- better mood
- No noticable side effects
I think of it as anti-lethargy++ : you do all the little things without getting tired. No brain fog either. The difference compared to noopept is that you won't think "better" (but "more" - just better perserverance).
So if you're smart enough you'll get focus+++. I can also see how this will lift people out of a foggy/lethargic period: the stuff kicks in in 2h and lasts all day. Use that energy to change your habits and focus, keep at it some time, continue living without ladasten (my theory being that after a few weeks you get used to a different rythm)
I do think the dose of 50mg in the AM is enough given the half life of 11h AND you need to good care of yourself given that you'll burn more energy. Anyway, it definitely battles something that lot of people "fight".
Thank you. I recently ordered some and am excited to give it a go.
@now 23 Sep 2012
I'll wait 2 days to wash out and get the cold out of my system and repeat to see if still gives these side effects. The positive effects were still there: enhanced focus and stamina, mood lifting.
Edited by @now, 23 September 2012 - 07:26 PM.
TiredAt45 23 Sep 2012
I'm glad Ladasten/Bromantan is finally getting some reviews. I hope it turns out to be beneficial.
@now 23 Sep 2012
I hope others start posting....
Climactic 23 Sep 2012
Sorry, but it is not at all appropriate for you to scream "side effects" from an isolated experience, considering everything else going on in your life. This thread is starting to become post-heavy and content-free. How about we take it for a week or two, or over a period of time, and then post our experience? This isn't a chatroom.phenylpiracetam seems to have less side effects so far
Edited by Climactic, 23 September 2012 - 08:54 PM.
Climactic 23 Sep 2012
You guys don't understand that people will be reading these threads years from now, and they'll have to parse through all this junk. Do you see the user chrono post like this? Or do you see research papers come out in ten parts? No. All I am suggesting is - use your words and your posts carefully. Write as if you're writing a Study of One.^
Just to let you know: downvoted you and upvoted him.
Edited by Climactic, 23 September 2012 - 09:27 PM.
Healthy Tony 24 Sep 2012
That being said, I was wondering if anyone could comment on long term tolerance buildup? Has anyone taken it for a few weeks or more?
Bigbrains 24 Sep 2012
All I could realy find on the net about this substance though is that it was used for some time by Russian Olympic Athletes with good results until Olympic Commitee made a special test to detect the drug and ban it. Seems like it does a pretty good job at what its supposed to do,but I'm surprised from looking at google that this drug never had much use out of Russia.
gizmobrain 24 Sep 2012
(also looking for a source of amisulpride, agomelatine, and phenylpiracetam)
Climactic 24 Sep 2012
(also looking for a source of amisulpride, agomelatine, and phenylpiracetam)
Nootrabiolabs has lately been selling bulk phenylpiracetam on ebay. CoA here. It is cheaper than Phenotropil and Demiurge. I have yet to try it in 100-300 mg doses. I also have to subjectively compare its taste and potency with the other two.
gizmobrain 24 Sep 2012
Nootrabiolabs has lately been selling bulk phenylpiracetam on ebay. CoA here. It is cheaper than Phenotropil and Demiurge. I have yet to try it in 100-300 mg doses. I also have to subjectively compare its taste and potency with the other two.
Hadn't seen this yet, thanks. These are the guys I got noopept from. The packaging didn't do much to inspire product confidence, but it seemed to be genuine.
@now 24 Sep 2012
I do think reactions should be "emotion free". "...with al the things going on in your life...." ? a) you don't know me and b) actually, nothing is going on, except for having a cold and being a bit lethargic because of that.
Anyway, let's make this topic worthwhile for future readers again. I do hope others will ( be able to ) post their experiences in due time.
Edited by @now, 24 September 2012 - 08:05 AM.
Tubemode 24 Sep 2012
Derivatives of adamantane, like memantine, are potentially neuroprotective drugs for the favourable care of Alzheimer's and Parkinson's diseases. A further adamantane derivate is N-(2-adamantyl)-N-(para-bromophenyl)-amine (ladasten) which is capable to modulate animal performance in different learning paradigms. To clarify if some of those behavioural alterations are mediated by modulation of catecholamine syntheses we studied the effects of single administration of ladasten (50 mg/kg, per os) on catecholamines' biosynthesis in the ventral tegmental area, nucleus accumbens, hypothalamus, striatum and hippocampus. We found that ladasten differentially regulates tyrosine hydroxylase mRNA and protein as well as dopamine and L-DOPA content. We then investigated the effects of ladasten on activity-dependent hippocampal synaptic plasticity in vitro and found that application of 10 microM ladasten transforms short-term potentiation of synaptic transmission to a long-lasting form. A transformation of short-term into long-term potentiation was also observed, when ladasten was applied 40 min after a single 100 Hz 200 ms tetanization. This reinforcement was blocked by the protein synthesis inhibitor anisomycin and could be attenuated by the D1/D5 receptor antagonist SCH23390. These results suggest that ladasten induces reinforcement of short-term potentiation via protein synthesis and dopamine dependent mechanisms.
If the two of you prefer, perhaps it is best if someone make a separate thread regarding the substance from a theoretical perspective.
Edited by Tubemode, 24 September 2012 - 10:13 PM.