11 replies to this topic

[Lyle Dennis]

http://extremelongev...human-lifespan/

[Marios Kyriazis]

The longevity action of Fox0 gene has been known for a while, and people have been trying to influence it for some years. Interesting research though.

[Freebytes]

This was interesting in regards to that gene. http://www.ncbi.nlm....8249 Basically, it appears that there is a drug that might influence it and also might have a positive impact on fighting leukemia.
Edit: fixed link. -mod

Edited by maxwatt, 20 December 2012 - 02:34 AM.

[knut]

So is there a way to increase FoxO in an animal?

FoxO has been shown to maintain continuous stem cell reproduction in all creatures. The Hydra is a good example because it seems to be immortal thanks to FoxO, whereas in humans and others FoxO drops as we age, leading to decreased stem cell production and death.

Edited by knut, 19 December 2012 - 05:48 PM.

[pleb]

This was interesting in regards to that gene. http://www.ncbi.nlm....8249 Basically, it appears that there is a drug that might influence it and also might have a positive impact on fighting leukemia.

when i tried the link it tells me it does not exist !

[niner]

This was interesting in regards to that gene. http://www.ncbi.nlm....8249 Basically, it appears that there is a drug that might influence it and also might have a positive impact on fighting leukemia.

when i tried the link it tells me it does not exist !

Hmm. It IS the ncbi, after all, so maybe they know something... Anyway, I fixed the link in the original post. However, that paper isn't about increasing the expression of FoxO, it's about increasing the expression of FoxO targets, which is a whole different matter.

[pleb]

Thanks niner, it does work now, but as you say it's about targets not about Fox O gene expression,

[1kgcoffee]

protein restriction:
http://www.ncbi.nlm....pubmed/18650956

Fits well with all of the recent studies on methionine restriction and mtor.

[niner]

Genome. 2008 Aug;51(8):668-72. doi: 10.1139/G08-047.
foxo is required for resistance to amino acid starvation in Drosophila.
Kramer JM, Slade JD, Staveley BE.

Department of Biology, Memorial University of Newfoundland, St. John's, NL A1B3X9, Canada. bestave@mun.ca

The ability of an organism to alter its metabolism, growth, and reproductive capacity in response to fluctuations in food availability has likely been an important factor in the course of evolution. The insulin signalling pathway is an evolutionarily conserved mechanism used by metazoan animals to sense and respond to changes in nutrient intake. During conditions of starvation the level of circulating insulin is low. Under conditions of low insulin, the foxo family of transcription factors are activated. Studies in Drosophila suggest that Drosophila foxo may alter the transcriptional profile of cells to allow for maximum survival of the fly during starvation. We have tested this ability in transgenic flies containing a luciferase reporter gene under the control of foxo response elements. We show that foxo activity is increased during amino acid starvation and reduced in the presence of amino acids. In addition, we find that loss of function of foxo leads to reduced survival under conditions of amino acid starvation in both larvae and adult flies. These data provide direct evidence that foxo is activated during amino acid starvation and is critical for optimal survival under these conditions.

PMID: 18650956

This is the abstract that 1kgcoffee linked in the previous post. I thought it was important (and short) enough to deserve a place here. If you want more foxo activity, maybe protein restriction will do the trick. This work was in flies, but drosophila and humans share a lot of conserved pathways, particularly for ancient survival-related pathways.

[Logic]

http://www.longecity...s-on-foxo-gene/
Wine, resveratrol, Olive Oil, tyrosol effects on FoxO gene

[nowayout]

Hydra immortality is really not immortality in any useful form. One might as well make a big deal out of the immortality of the human germ line.

[Marios Kyriazis]

Hydra immortality is really not immortality in any useful form. One might as well make a big deal out of the immortality of the human germ line.

...Or that of cancerous cells