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rhodiola warning

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#31 normalizing

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Posted 15 March 2018 - 01:04 AM

E and C are highly pro-oxidants too. i would recommend against regular ingestion of them in pill form and concentrate on foods that contain them


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#32 Nate-2004

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Posted 15 March 2018 - 02:05 AM

E and C are highly pro-oxidants too. i would recommend against regular ingestion of them in pill form and concentrate on foods that contain them

 

They aren't pro-oxidant, highly anti-oxidant, which has its own problems. Alpha-tocopherol alone without gamma can be problematic and too much of both E and C is also problematic especially where ROS can benefit such as exercise and other ways of creating a stress response. It's fine in this occasional use case of taking potentially neurotoxic drugs or drugs that inhibit reuptake as a protective measure. Food sources are fine too but there's really no difference other than inclusion of lipids for bioavailability and other micronutrients. Also, almonds are mostly alpha tocopherol (25:1) while walnuts are mostly gamma (28:1), so... you'd have some of the same issues, you'd want to balance those out anyway. 


Edited by Nate-2004, 15 March 2018 - 02:05 AM.


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#33 hav

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Posted 22 March 2018 - 03:13 PM

are you sure its only 45 mins half life? i remember dosing on that stuff, maybe 2 caps at most, and it lasted like 6 hours the stimulation that is. maybe you mean something else in it lasts just 45 mins? because certainly, the stimulation keeps going for a while

 

 

Like I said, read the page on examine, it's got references. I agree with you, the effects seem to last, which is not unheard of. It could just be that it's a really strong MAO-B inhibitor and then once it wears off it takes time for MAO to deal with all that dopamine. One study showed an AUC of 240 mins which is the total drug exposure time from what I understand. That's a good 4 hours. This was all in mice though so who knows what it does in humans.

 

I'm considering taking it every 4 days, which is what I do with modafinil. I don't know if I will do it with modafinil or in alternation with it (mod, then 2 days later rhodiola, then 2 days later mod).

 

I used to take that myself and noticed it's effect on my blood pressure lasted about 8 hours.  I took a look at the page on examine (Sec 2, Pharmacology, 2.2 Serum) where one study documents the half life of salidroside to be 45 minutes in the blood stream of rats.  This study does not represent the time salidroside disappears from the body of a rat which would be determined by organ analysis of perhaps liver, lungs, brain, and fatty tissue.  Also this study only measured salidroside and not p-tyrosol, rosavins, and procyanidins which are also present in Rhodiola in significant amounts.  Fwiw, the examine page also references a 2nd rat study that observed a blood stream half life of 1.32 hours measuring salidroside and  p-tyrosol together.

 

Howard



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#34 normalizing

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Posted 23 March 2018 - 02:57 AM

 

E and C are highly pro-oxidants too. i would recommend against regular ingestion of them in pill form and concentrate on foods that contain them

 

They aren't pro-oxidant, highly anti-oxidant, which has its own problems. Alpha-tocopherol alone without gamma can be problematic and too much of both E and C is also problematic especially where ROS can benefit such as exercise and other ways of creating a stress response. It's fine in this occasional use case of taking potentially neurotoxic drugs or drugs that inhibit reuptake as a protective measure. Food sources are fine too but there's really no difference other than inclusion of lipids for bioavailability and other micronutrients. Also, almonds are mostly alpha tocopherol (25:1) while walnuts are mostly gamma (28:1), so... you'd have some of the same issues, you'd want to balance those out anyway. 

 

 

did you try google? it clear has dozen of articles stating E and C can pro-oxidant. and silly me, i got tricked by wikipedia initially, but screw the troll who edited the page that day. and i guess his friends are continuing his mission to state E and C are pro-oxidant because it hasnt changed since...


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