5 replies to this topic

[tham]

Effects of dairy consumption on SIRT1 and mitochondrial biogenesis
in adipocytes and muscle cells


" Data from this study indicate that not only leucine but also its metabolites
HMB and KIC are direct activators of SIRT1 enzyme. "

" Since SIRT1 is a negative regulator of NF-κB and attenuation of NF-kB
activity by SIRT1 results in suppression of TNF-α ; , it is possible that the
above mentioned effects of HMB are mediated, at least in part, by HMB
activation of SIRT1. "

" ..... It is likely that SIRT1-independent pathways also modulate some of the
effects of dairy components. AMP-activated protein kinase (AMPK), a key
regulator of energy metabolism, is a likely target, as it also serves
as an energy sensor and regulates cellular metabolism. "

" Since adiponectin activates AMPK, and we previously demonstrated the
high dairy diet to increase adiponectin, adiponectin stimulation of AMPK
may play a significant role in the observed effects. "

http://www.nutrition.../content/8/1/91

[tunt01]

I love this last part of the paper:

In addition, we did not examine the mechanism how leucine or its metabolites directly stimulate SIRT1, and cannot exclude the possibility that binding to the fluorophore used in the SIRT1 assay contributes to the observed increase in SIRT1 activity.

and PS, this study was:

Supported by the National Dairy Council and administered by the Dairy Research Institute.

[YOLF]

so it increases expression of SIRT1 in adipocytes (fat cells) and muscle, or just fat?

[joelcairo]

.

Edited by joelcairo, 17 March 2013 - 04:05 AM.

[YOLF]

Should I read that as it does it period?

[joelcairo]

LOL, I kind of lost interest in my post by the time I had finished it, and couldn't figure out how to delete it outright. Basically I was pointing out that there's hardly any leucine in milk anyways. There's a lot more in cheese, but even cheese doesn't exactly stand out as a source in comparison to other protein-rich foods.