http://en.wikipedia....ramiracetam.svg
This is the Pramiracetam molecule. I was looking at it recently and it got me thinking. Everyone here talks about Pramiracetam being fat-soluble, that it needs to be taken with a fat source etc, however when you look at the molecule it looks like it would be fairly water-soluble too. I don't know a tremendous amount about chemistry, however the polar ends at the two oxygen atoms, as well as the nitrogen atom surrounded by hydrogen, would certainly provide a polar enough environment for water-solubility.
To that end, I just did some tests. I took 185mg of Pramiracetam and dissolved it into filtered water. I can say that at .5 oz water, it fully dissolves, very quickly. This wasn't even an issue of having to force it to dissolve through stirring, it just simply very easily dissolved into solution. And to this, I say that it's pretty clear that Pramiracetam is highly water-soluble as well as fat-soluble. It does not necessarily need to be taken with a fat source to be effective. If I had more Pram to spare, I would test it further and see how low I could take the water dose before it's no longer fully soluble.
Just wanted to clear that up here, and perhaps get some input on this from more-knowledgeable people.
