Interesting observations. I'd love to start his muscle building program(s), but it may be heard for me to get in 4-5k calories without resorting to heavy whipping cream or simply eating tons of carbs every day. Now, I'm really trying to add nutrient dense foods into my diet, because even after adopting an ancestral-style diet, I never added them in, simply excluded lots of toxins; now I'm adding in chicken livers, gizzards, backs, feet, and I should be receiving some Deer organ meats from my fiances step father - hopefully liver, kidney, and heart. Most of which aren't
too calorie dense. I agree that creating adequate mucin/polysaccharides, etc. via gluconeogenesis may be stressful, especially in the long term. I simply don't have enough research done on what may be optimal, but right now, in the modern world (yet depending on goals, genetics and epigenetics, and so on) I think operating both metabolic pathways (energy via beta-oxidation or using glucose) may be wise. This lends some merit (from experience and research) to Dave Asprey's ideas on cyclical ketogenic dieting, and Steven Fowkes has alluded to cycling in and out of ketosis, though not making it a metric to track ("am I in ketosis right now?!?!"). After viewing a lot of the results of Ben Greenfield, Peter Attia, and most incredible of all, Barry Murphy (Ross?), I think ketosis may benefit highly intense activities as well, especially when activating PGC-1a (although I've seen PGC-1beta being better for beta-oxidation, alpha being for glucose oxidation, and PQQ works PGC-1a...), brown and beige fat, and so on, fats can be used even better. Carbs can be consumed while still maintaining proper fatty acid utilization, and to a degree, beta-oxidation.
I'm just not certain on what's optimal, but I suppose it is entirely individual, hence why I want 23andMe and Organic Acid Testing done on myself. I was reading some portions of Vilhaljmur Steffanson's books, and he actually cited the Inuit eating carbs even in winter - keep in mind this is POLAR winter. They ate berries, found in ground starchy foods, twig-like foods, digested carbs in animals and fish, and so on.
I think Jaminet's argument, from interviews I've heard, is that fructose is detrimental to the liver, increases trigs, and forms AGEs. Again, this isn't shown in the most up to date literature not using supraphysiological, isolated, non-whole foods forms of fructose. Fructose actually forms reducing equivalents in the Pentose Phosphate Pathway (I need to learn more about this pathway, so I'm not entirely certain on the implications here) in the form of NADPH, can create phospholipids, can be turned into glucose, and is surprisingly less anti-ketogenic than glucose, and possibly galactose. Fructose is actually a 'ketose', rather than an aldehyde:
http://www.elmhurst....43fructose.htmlhttp://chemed.chem.p...yde.html#commonI wonder if that is at least partly why it has been used with success in diabetic patients. If ketosis is stressful and solely mimics the starvation processes (which it does, but as far as I can tell that isn't necessarily a bad thing - activates chaperone mediated autophagy, among other interesting things), it seems as though fructose would be the best way to maintain adequate metabolic 'efficiency' (not damaging your beta-cells, maintaining low(er) blood glucose, increasing RMR, producing CO2, NADPH, etc.), along with adequate use of other glyconutrients such as galactose, d-ribose, xylose, xylitol, and so on.
Edited by BigPapaChakra, 25 October 2013 - 04:11 AM.
