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SSRI long term damage/risk thread

ssri serotonin antidepressant anxiety depression attention adhd libido long term

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#31 Sunwind

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Posted 28 May 2013 - 09:59 AM

Agreed, mostly. I would place sex at a pretty high place on my pyramid. What would be lower, however, is the need for relationships/contact. I would far rather have a good relationship without sex than good sex without a relationship.

To relate this to the topic of the thread, my entire reason for wanting to be more social is because contact with people is extremely pleasurable to me, and I want it badly. The few times that I have had contact in a relational sense, briefly(and very mildly) involved with a girl in highschool, it was only things like hugs, hair-playing, and stuff like that, but it was a hugely great feeling, better than opioids as I compare the memories. I can endure loneliness. I am not going to be driven crazy because of it, but I am afraid that, by taking an SSRI, the blunting would prevent that sort of feeling, and, to be honest, I don't care for socialization if that were to occur. What is the point in reducing how much I care about it in order to get it (in a sub-desirable form)?

This is why I don't understand SSRIs for social anxiety. Aside from my specific problems, if we assumed that someone was totally resistant to the side effects and had super-concentration, and the only purpose was for the reduction of social anxiety via the dampening mechanism, it still seems like a HUGE compromise. I mean, yeah, the emotions can be overwhelming, especially when negative, but why not increase ability to deal with them instead of repressing them or try to only decrease the negatives? Is it to be more functional is a job/school or something? Does anyone have a counter to this? I can see how things like panic/severe depression could be justified this way when they make it impossible to enjoy anything anyway, so less of good and bad emotions is okay as long as it is less of the bad which were dominating your life in the first place, but in social anxiety, taking away part of the want to be social so that you can be more social seems counter-productive. Maybe I am stuck in the nootropic mentality that medicines should ONLY do good with extremely little harm.

Am I wrong about how this works? I would be interested in hearing how SSRI has helped your anxiety/social anxiety without a general dampening of emotions. Depression not so much included here, as depression itself can be mood suppressing, and probably increases in BDNF that cause an exit of depression are what cause the net increase in emotionality, but, hey, if you want to tell your story, I am not going to stop you :D.


I have that need aswell, what I mean is as an animal we have this driving force to procreate, the biological imperative, and if you are horny enough it's enough to push through any anxiety. I don't just want sex by any means, but there's no relationship if you don't even speak to them, and the horny-ness can help with that to begin with, after that fap away.

My emotions are definitely blunted while on Venlafaxine (SNRI) right now, but I still feel, I just walked my dog and was laughing while he tried to mate with another dog much bigger than him (he's a corgi). It doesn't make you a complete robot, at least in my experience. It may even seem worse than it is because when people stop taking them, the full emotions will come back and they might seem much more intense than normal because you're not used to it, just a thought.

Also I can't really tell if it has helped with my anxiety, I started it in october last year after I came home from university after being there for 1 week (couldn't handle it), when I got back I got my dog and I think that helped a lot by forcing me to leave the house nearly every day, so it's really hard to say, I still have a long way to go though. I would say if your anxiety is stopping you from doing anything, you should at least give an RI a try (Escitalopram?).

#32 magniloquentc0unt

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Posted 28 May 2013 - 11:08 AM

yes i have had permanent side effects from fluoxetine, emotional blunting and genital anaesthesia. stay away from that substance. you could try moclobemide for your symptoms. I wouldve said tianeptine too but in my experience it raises social anxiety

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#33 magniloquentc0unt

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Posted 28 May 2013 - 11:24 AM

Libido is definitely linked with motivation/"risky" behaviour. Have you heard of No Fap? This video explains quite clearly how libido is linked with motivation and how it can cause social anxiety etc.

I agree with the sexual motivation and social motivation being interlinked, and it does make a lot of sense. In more schizoid phases, when I have almost no social motivation, I also tend to have no sexual motivation. However, porn and similar things remain as pleasurable. If the social aspect is removed, the actual sex and porn still entertains/arouses me. I just lose interest in people and thus in any thought of having sex with them. Don't mean to get too side-tracked, but do you notice the same thing? Do you find yourself averse to the idea of sex itself or just to the interactions of people and social aspect of it?


I'm exactly the same way. I find when I am not on an antidepressant and I abstain from fapping, my libido/motivation goes through the roof and almost forces me to interact with people to satisfy my base desire to get my dick wet.


Thanks for the link and the video. This is extremely interesting and maybe i should give it a shot, i have the feeling im on the exact same boat

#34 nowayout

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Posted 28 May 2013 - 05:28 PM

From what little experience with SSRIs I have, they seem to reduce your ability to concentrate, so you don't fall into a spiral of negative rumination - you just can't keep up the concentration for that.

#35 nupi

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Posted 28 May 2013 - 08:04 PM

I have that need aswell, what I mean is as an animal we have this driving force to procreate, the biological imperative, and if you are horny enough it's enough to push through any anxiety.


Not for me, it isn't. I also have exactly zero desire to procreate (if we didn't have reliable birth control, I wouldn't even consider getting laid).

Edited by nupi, 28 May 2013 - 08:07 PM.


#36 Sunwind

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Posted 28 May 2013 - 08:06 PM

I have that need aswell, what I mean is as an animal we have this driving force to procreate, the biological imperative, and if you are horny enough it's enough to push through any anxiety.


Not for me, it isn't.


not horny enough then

#37 nupi

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Posted 28 May 2013 - 08:08 PM

not horny enough then


It never was enough,not at 14, not at 20 not now at 30. Arguably that says more about my anxiety, than anything else.

#38 Sunwind

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Posted 28 May 2013 - 08:10 PM

not horny enough then


It never was enough,not at 14, not at 20 not now at 30. Arguably that says more about my anxiety, than anything else.


i'm not deadly serious, anyway :) I know that feel

#39 nupi

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Posted 28 May 2013 - 08:19 PM

I wonder if SSRIs primarily work through mood-blunting to decrease anxiety. Of course, that would translate to lower ratings on social anxiety, but also lower quality of life for those of us with social anxiety but lacking generalized anxiety.

SSRIs are kind of marginal against SAD anyway. They do a pretty good job of getting rid of my GAD (mainly because I don't really care).

For generalized anxiety, they seem to work primarily by blunting, which may or may not be the best solution. MAOIs may be better tolerated with a proper diet.

Good luck finding a shrink that gives you one.

In cases of OCD or obsessive anxiety, inositol would be a better 1st line treatment, I think. It is safer and should have fewer side effects to people who are not ADHD.


I never really got to do it much at all for me.

It could also be a form of atypical depression... Did you try switching Eszopiclone for another sleeping medication?

In my case, the reading is partially replaced by watching movies but the point stands (I was never much of a fiction reader and usually can't be bothered to get started with books although if I do, I generally do finish them). But the "I know intellectually I should be bothered with this" or wasting my life part sounds pretty familiar. Unfortunately, choosing between being depressed and anxious (and not really doing anything productive with live, either with all motivation coming from anxiety) and being in a sort of SSRI lull that at least takes care of the anxiety to some degree, the SSRI clearly does win out. It of course does not help that I have pinched nerve in my neck that prevents me from doing sports since 2 months and typing quite painful (physiotherapy is slowly making it better but it will be a while still)...


Have you considered the possibility that you may have a mild form of ADHD? It is possible for this sort of thing to occur because of depression, but the fact that it gets WORSE with SSRIs means you should maybe at least look into it.


I test kind of borderline for ADD-PI (although I believe it is mainly because I have stellar scholar track record which is a big element in contributing to a no Adult ADD diagnosis). My nitwit shrink refuses to even let me try MPH, arguing that I don't have any of the typical problems it addresses. Coincidentally, I also test borderline onthe spectrum (but a lot of the spectrum and ADD-PI overlap, so that is not too surprising).

#40 Sunwind

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Posted 28 May 2013 - 08:23 PM

I've been thinking I recently had something to do with ADD, the problem with anxiety/depressive disorders is there is a FUCKTON of overlap between different disorders and such, I don't think we have a single true cure for anything either, it's mostly just treating the symptoms for the vast majority of people, isn't it?

Also, isn't there something to do with abolishing the ADHD/ADD diagnosis recently because it "doesn't exist"? my impression was that too many similar things are being put under the ADHD/ADD umbrella because of all the overlap.

#41 nupi

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Posted 28 May 2013 - 08:28 PM

This is why I don't understand SSRIs for social anxiety. Aside from my specific problems, if we assumed that someone was totally resistant to the side effects and had super-concentration, and the only purpose was for the reduction of social anxiety via the dampening mechanism, it still seems like a HUGE compromise. I mean, yeah, the emotions can be overwhelming, especially when negative, but why not increase ability to deal with them instead of repressing them or try to only decrease the negatives? Is it to be more functional is a job/school or something? Does anyone have a counter to this? I can see how things like panic/severe depression could be justified this way when they make it impossible to enjoy anything anyway, so less of good and bad emotions is okay as long as it is less of the bad which were dominating your life in the first place, but in social anxiety, taking away part of the want to be social so that you can be more social seems counter-productive. Maybe I am stuck in the nootropic mentality that medicines should ONLY do good with extremely little harm.


They do not really do too much about social anxiety but at the very least they make the results of it more tolerable. And they treat my GAD which helps me both in not going crazy in my job and having a more peaceful live. So very clearly, they are not a cure to me but more of a coping device. Still given the choice between anxiety, depression and your life going down the drain because of it and a dull but otherwise halfway successful life on an SSRI, the SSRI wins, hands down.

Would there in theory be a better option? Of course. Just like an Audi R8 is a much nicer car than a VW Golf. The R8 is out of reach for most. As it stands, for me, it is easier to be able to buy the R8 than fix my head (the main reason that I do not get one - or any other dream car - is related more to the fact that I don't actually need a car in my life)

#42 Saladface

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Posted 29 May 2013 - 11:34 PM

First post here, yay ;)

On SSRI's in one way or another for maybe 12 years or so. Depression, anxiety, OCD. Maybe about 20% effective but the mechanism of action seems to be a general blunting of everything to do with the brain. My pure O OCD was hellish enough for me to stay on them for this period despite their limited effectiveness. I only came off them when the side effects (tiredness, weight gain etc) had become so terrible I had no other choice.

Been off them over a year now, persisting side effects are a lack of motivation and almost no sex drive. Like many others the low sex drive isn't a problem, but the low general drive is. While on them I didn't care, now I do (so there is some drive) but actually doing something is very hard work. I still suffer with depression and to a lesser extent OCD, but it is hard to be objective re these meds as to what they actually did to me long term. My gut feeling is they fucked me over handsomely, but I am aware I felt like shit before taking them too, so it could be scapegoating on my part.

Back when I started taking them, almost none of the problems with SSRI's were known (or were hidden). They were seen as basically super low side effect versions of tricyclics by doctors, and they gave them out like candy. A lot of this persists today and their efficacy is greatly exaggerated imo.

My advice for what it is worth regarding SSRI:

1)Don't take them unless you have tried absolutely everything else.
2)If you do take them, get as many possible tests as you can before starting. Hormonal (esp thyroid, testosterone), lipids, ECG, insulin resistance, basically anything that gives you a baseline for your health without medication. (this is probably sensible for anyone about to take any medication for a while). Regarding any potential hormonal effects of these drugs, the 'normal' test ranges are so wide, without a baseline test you could have a 50% drop in testosterone due to these medications and it would still appear as normal. My testosterone levels after the medication are low normal, I suspect the SSRI's caused this but I can't say for sure without a baseline test.

#43 Sunwind

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Posted 30 May 2013 - 04:17 PM

I spoke to my doc today about Escitalopram, and he said it can be taken with Venlafaxine, he gave me a prescription for Escitalopram 10mg, and wants to lower my Venlafaxine dose to 150mg instead of 225mg at the same time. First I need to have an ECG test to check my heart baseline or something, and then after a few weeks have another to see if the medication causes a change or something. What do you guys think of this, could it be helpful to me for my anxiety than just the larger dose of Venlafaxine alone?

#44 nowayout

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Posted 30 May 2013 - 06:04 PM

I spoke to my doc today about Escitalopram, and he said it can be taken with Venlafaxine, he gave me a prescription for Escitalopram 10mg, and wants to lower my Venlafaxine dose to 150mg instead of 225mg at the same time. First I need to have an ECG test to check my heart baseline or something, and then after a few weeks have another to see if the medication causes a change or something. What do you guys think of this, could it be helpful to me for my anxiety than just the larger dose of Venlafaxine alone?


Why take an SNRI and an SSRI? It doesn't make much sense and it is not, afaik, a common standard of care.

Edited by nowayout, 30 May 2013 - 06:04 PM.

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#45 magniloquentc0unt

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Posted 30 May 2013 - 06:05 PM

the only reason it would make sense is if you're entering a washout period

#46 Sunwind

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Posted 30 May 2013 - 06:08 PM

http://apt.rcpsych.o...nt/15/2/90.full

This is all I could find on combining antidepressants.

SSRI with SNRI

This combination of an SSRI and the SNRI venlafaxine is now being seen in practice, but it does not make for rational polypharmacy as venlafaxine has predominant SSRI activity, particularly at low doses. Gonul et al (2003) report on four patients who only partially responded to high-dose venlafaxine but fully responded to SSRI–venlafaxine combination. To reduce the risk of serotonin toxicity, the SSRIs were added to lower than the maximum dose of venlafaxine.


Edited by Sunwind, 30 May 2013 - 06:10 PM.


#47 brainslugged

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Posted 31 May 2013 - 04:21 AM

Went to my GP today and convinced her to give me a non-SSRI, bupropion.

So, I am going to try that out, it has a much better safety profile.

Still, every doctor wants me to try an SSRI. It is troublesome. They won't give me a MAOI instead. It was a very tough battle just to get the bupropion.

I am kinda wondering the same thing as protoject, here now. What would be the harm in taking, say, 10mg paxil (when 20mg is normal dose) for a month or two?

If I can take a few SSRIs and try them, my doctor agreed to try other things since I would have shown that I don't react to them well, but she doesn't understand my concerns about SSRIs.

She absolutely refuses to put me on a stimulant since I am underweight and make good grades, so I am "functional" although she agreed that I have strong ADHD-PI symptoms. Fair enough, I guess. I can understand reluctance to put someone with social anxiety and a BMI of 18.5 on a stimulant. It took a lot of promising to eat more just to get the bupropion.

So, what is the chance of harm in a month or so's trial of paxil, and then probably a month or so's trial of zoloft or prozac, to prove that SSRIs don't fix my problem? If I prove that I am treatment resistant(really, to prove that my problem isn't panic, but more ADD/AvPD), then this whole thing can be over with. Maybe then I could get MAOIs or I guess a stimulant since that is absurdly probably going to be easier to get.

They do not really do too much about social anxiety but at the very least they make the results of it more tolerable. And they treat my GAD which helps me both in not going crazy in my job and having a more peaceful live. So very clearly, they are not a cure to me but more of a coping device. Still given the choice between anxiety, depression and your life going down the drain because of it and a dull but otherwise halfway successful life on an SSRI, the SSRI wins, hands down.

Would there in theory be a better option? Of course. Just like an Audi R8 is a much nicer car than a VW Golf. The R8 is out of reach for most. As it stands, for me, it is easier to be able to buy the R8 than fix my head (the main reason that I do not get one - or any other dream car - is related more to the fact that I don't actually need a car in my life)


I see your point. From that perspective it makes sense. However, I don't constantly suffer, and most of the time, I am pretty happy although maybe lonely (but that is what I have the internet for, lol).

From a theoretical view, if I could get a girlfriend with whom I had a close relationship, all my social needs would pretty much be filled between that and the internet. However, a major problem I have is with getting irritated/annoyed at friends who want me to do things all the time, and I can't. Sorry, I don't have the willpower to play a strategy game for 5 hours/day. I get focused in on forums and everything, and I start to neglect my friends, feel irritated around them. That obviously cannot fly in a relationship, it barely works in friendships, and only because they know I have always been like this. On the ritalin, this problem was solved. I was fine. I didn't get flightly/annoyed from being around people for too long. I am ranting now, so best to stop. I am just frustrated at the whole doctor-pharm system thing right now. FFS, I know what will help me, why can't I have it? I guess that does kinda sound like an addict-mentality, but it is hard not to want something that works so well. Sorry for the rants in this thread, just been having frustrating times with doctors. Don't let them distract from the actual goal of the thread :)

I spoke to my doc today about Escitalopram, and he said it can be taken with Venlafaxine, he gave me a prescription for Escitalopram 10mg, and wants to lower my Venlafaxine dose to 150mg instead of 225mg at the same time. First I need to have an ECG test to check my heart baseline or something, and then after a few weeks have another to see if the medication causes a change or something. What do you guys think of this, could it be helpful to me for my anxiety than just the larger dose of Venlafaxine alone?


Why take an SNRI and an SSRI? It doesn't make much sense and it is not, afaik, a common standard of care.

Yeah, it doesn't quite make sense to me either, but I have actually heard of it quite a bit.

The most sense I could make of it is that maybe they have different affinities for different parts of the brain? We don't even know information that specific about the drugs, though, so it would have to be some kind of "I tried this with other patients and it seemed to work" sort of thing. That being said, I think it IS plausible that it could be more effective.

#48 magniloquentc0unt

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Posted 31 May 2013 - 03:04 PM

keep us updated on any cognitive decline you might experience

#49 brainslugged

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Posted 31 May 2013 - 03:45 PM

I am wondering if anyone has experience combining Piracetam with SSRIs, and if it decreased side-effects.

Or, if anyone has experience combining SSRIs with NMDA antagonists, which may be able to reduce the desensitization of 5HT receptors. I wonder if this would negate theraputic effects, though.

#50 nowayout

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Posted 31 May 2013 - 04:18 PM

I have the same problem with doctors not "getting" my concerns with SSRIs.

Female doctors don't seem to get why sexual desire and function can be important to men. Older male doctors who have been married a long time and probably don't have sex anymore anyway are completely oblivious as to why a single guy might worry about losing sexual function. I had a doctor tell me seriously that it's okay because even if I lose desire the drug will make me not worry about it, and I'll have the advantage of reduced exposure to possible STDs.

#51 Sunwind

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Posted 31 May 2013 - 04:45 PM

I've been on Venlafaxine since October, it's an SNRI that acts on serotonen aswell as norepinephrine, and at larger doses dopamine. I started taking Piracetam yesterday in 5g doses (3/day, every 5 hours from 9am, or whenever I wake up).

Today I have felt my mood uplifted quite a bit, which may not be remarkable on its own, but I've been feeling shitty and depressed since, well, around October, so if this effect from Pira doesn't diminish as the days go by (I really hope not, you're not meant to build a tolerance to it are you?) then that will be at least decreasing the numb-mood effect of the SNRI. The other side effect I get is low libido, hasn't had any effect on that yet, and I can't really see it happening since Pira isn't known to increase libido (As far as I know). I'm keeping a log and can update weekly if you want.

Edited by Sunwind, 31 May 2013 - 04:47 PM.


#52 brainslugged

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Posted 31 May 2013 - 06:38 PM

I've been on Venlafaxine since October, it's an SNRI that acts on serotonen aswell as norepinephrine, and at larger doses dopamine. I started taking Piracetam yesterday in 5g doses (3/day, every 5 hours from 9am, or whenever I wake up).

Today I have felt my mood uplifted quite a bit, which may not be remarkable on its own, but I've been feeling shitty and depressed since, well, around October, so if this effect from Pira doesn't diminish as the days go by (I really hope not, you're not meant to build a tolerance to it are you?) then that will be at least decreasing the numb-mood effect of the SNRI. The other side effect I get is low libido, hasn't had any effect on that yet, and I can't really see it happening since Pira isn't known to increase libido (As far as I know). I'm keeping a log and can update weekly if you want.

Wow. That is a lot of piracetam. I guess if you can tolerate that much, then it is good. So far you seem to be doing well with it.

Yeah, in my experience, piracetam has a WONDERFUL mood-lifting effect, especially in the long term. I could not tolerate high doses (over 1.5g is anti-cholinergic and generally bad feeling for me, and I don't want to take choline daily), so mine tended to have a slow effect, but I have heard that higher doses have a quicker onset, so hopefully you will have a swift and effective treatment with it.

Unfortunately, like you said, it doesn't seem to have any effect on libido.

It is exciting to see that it is helping with the mood-numbing side-effect. Keep us updated.

As far as your statement about ADHD, I have heard that it is both under-diagnosed and over-diagnosed. It is over-diagnosed in that many children with opposition defiance are simply diagnosed as ADHD when the problem is most likely more complex than that, maybe partially to do with parenting or with an anti-social personality/sociopathy. At least where I live, MANY children are diagnosed with ADHD purely based on oppositional defiance and the child being energetic. Although a lot of these may be due to ADHD, many times they may be better solved with CBT or even anxiety medicine. Still, in most of these situations, ADHD is the proper diagnosis, and it probably isn't extremely overdiagnosed. There seems to be a very strong opposition against ADHD diagnosis and treatment by people who spout BS about ADHD being a "gift" or about how stimulant medicines are extremely addictive and are "virtually identical to speed", and these people seem to strongly push the idea that ADHD is underdiagnosed or false, and that it is simply a different way of learning.

On the other hand, ADHD is under-diagnosed in the adult and inattentive population. Often, it is mistaken for anxiety or depression, which may be there, but are caused by the troubles associated with Adult ADHD/ADHD-PI. There is also, unfortunately, a fairly common belief that adults "outgrow" ADHD, which is not true.

The fact that it is overdiagnosed (or at least considered to be overdiagnosed) in many situations hurts the people who do need to be diagnosed. Unlike what is said about the drugs, Ritalin seems to be a very safe and effective treatment for attention problems, as safe or safer than SSRIs. Ritalin is NOT speed. It is neuroprotective and even increases BDNF. The drug war has done a lot of harm to people who need ADHD drugs. As long as they are used responsibly, they are very safe and effective. Even amphetamine, "speed", can be administered responsibly and safely when it is combined with memantine and possibly with selegiline (although there is not enough evidence to know the safe dosages of the combination)

I have the same problem with doctors not "getting" my concerns with SSRIs.

Female doctors don't seem to get why sexual desire and function can be important to men. Older male doctors who have been married a long time and probably don't have sex anymore anyway are completely oblivious as to why a single guy might worry about losing sexual function. I had a doctor tell me seriously that it's okay because even if I lose desire the drug will make me not worry about it, and I'll have the advantage of reduced exposure to possible STDs.


Wow. That is a horrible attitude by the older male doctor. It is scary to think that they are treating people with that kind of attitude. With that kind of attitude, why don't we all just get lobotomies and sit around blissfully watching TV all day? Hey, reduced chance of dieing in a car crash!

Yeah, the female doctor who I went to didn't seem to understand my concerns that it could be possible. She said, even if it was 1 or 3 percent of lasting sexual effects, you benefit more from getting it treated. I disagree. My social anxiety doesn't kill me, I can be happy despite it. Losing libido would be horrible for my happiness.

Even more frustrating, though, is when they don't understand the possiblity of losing cognitive ability. I brought up that paxil reduces word recall. She said that since I was an honors student with a's, it wouldn't matter much if I lost a little mental ability -and since I was so skinny, it wouldn't hurt if I gained 20lbs-. That is part of the reason I don't fully trust the general opinion of SSRIs by doctors. Most people don't seem to think that losing a little mental ability is really a big deal. Maybe they will be a bit more forgetful, but if they can live a normal life, they are happy. Admittedly, like nupi said, this can be well worth it to some people, but it doesn't mean it is worth it to me, and I hate that others feel like they can tell me it will be worth it. At a normal digit span of 6, it is a wonder that I am able to do as well as I do in school; I don't want to push it.

Actually, though, here is a study against negative effects of paxil on working memory http://www.ncbi.nlm....pubmed/17219219 It is actually kinda positive. Of course, it is with rats, and negative human trials override them in my mind. Still interesting.
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#53 Sunwind

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Posted 31 May 2013 - 06:45 PM

I believe the weight-gain from antidepressants is due to increased appetite/overeating, and not any kind of metabolic disruption (correct me if i'm wrong), so as long as you have some self-discipline you shouldn't worry about weight gain. I've even lost weight while on this from changing my diet and exercising a bit.

Edited by Sunwind, 31 May 2013 - 06:48 PM.


#54 nowayout

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Posted 31 May 2013 - 06:55 PM

I believe the weight-gain from antidepressants is due to increased appetite/overeating, and not any kind of metabolic disruption (correct me if i'm wrong), ...


Not sure. I have seen a study showing deleterious effects on blood lipids from sertraline, probably others too.
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#55 prunk

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Posted 31 May 2013 - 06:56 PM

I believe the weight-gain from antidepressants is due to increased appetite/overeating, and not any kind of metabolic disruption (correct me if i'm wrong), so as long as you have some self-discipline you shouldn't worry about weight gain. I've even lost weight while on this from changing my diet and exercising a bit.

When I had a short trial with Agomelatine a few months back, I gained about min 3kg in a two weeks. My diet was exactly the same as before ( a very strict one ) as was my training routines. The same happened with MIrtazapine and Sertraline a few years ago. Although not as quickly as with Agomelatine, I guess.

Edited by prunk, 31 May 2013 - 07:01 PM.


#56 Sunwind

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Posted 31 May 2013 - 06:58 PM

I believe the weight-gain from antidepressants is due to increased appetite/overeating, and not any kind of metabolic disruption (correct me if i'm wrong), so as long as you have some self-discipline you shouldn't worry about weight gain. I've even lost weight while on this from changing my diet and exercising a bit.

When I had a short trial with Agomelatine a few months back, I gained about min 3kg in a two weeks. My diet was exactly the same as before ( a very strict one ) as was my training routines.


I see, maybe it's different with different antidepressants, or it just doesn't happen to some people for whatever reason they don't get other side effects (or do).

#57 prunk

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Posted 31 May 2013 - 07:06 PM

I think with Agomelatine the reason was water retention and with Mirtazapine and Sertraline pure and nice fat.

#58 arcticjoe

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Posted 01 June 2013 - 08:11 AM

my 2c - have been on lexapro and zoloft in the past, both worked well for my depression and oddly enough seemed to actually boost my libido (zoloft more so than lexapro)... not many physical sides to report, but they do change your personality somewhat. In hindsight i feel like i was a bit of a arsehole on lexapro and I really did not give a sh1t about much whilst on zoloft, including important things like work and relationships. In the end my performance at work dipped so I slowly tapered off.

#59 nupi

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Posted 01 June 2013 - 08:37 AM

Went to my GP today and convinced her to give me a non-SSRI, bupropion.

So, I am going to try that out, it has a much better safety profile.


It has it's very own problems though. With a BMI of 18, I would be seriously worried about its appetite-suppressing tendencies. It has also has a way of making you OCD without you really noticing it, at first. Finally, it has the odd report of memory issues.

I am kinda wondering the same thing as protoject, here now. What would be the harm in taking, say, 10mg paxil (when 20mg is normal dose) for a month or two?

If I can take a few SSRIs and try them, my doctor agreed to try other things since I would have shown that I don't react to them well, but she doesn't understand my concerns about SSRIs.


You can also always just pretend to take them...Personally, I would give it a shot thoyugh.


I see your point. From that perspective it makes sense. However, I don't constantly suffer, and most of the time, I am pretty happy although maybe lonely (but that is what I have the internet for, lol).

From a theoretical view, if I could get a girlfriend with whom I had a close relationship, all my social needs would pretty much be filled between that and the internet.


That's a recipe for disaster. Relationships can, do and will break apart at which point the in-person support network is most critical.
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#60 nupi

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Posted 01 June 2013 - 08:59 AM

Yeah, the female doctor who I went to didn't seem to understand my concerns that it could be possible. She said, even if it was 1 or 3 percent of lasting sexual effects, you benefit more from getting it treated. I disagree. My social anxiety doesn't kill me, I can be happy despite it. Losing libido would be horrible for my happiness.


I am a male and I really do not get that whole but it will lower my libido concern - especially not if you are single, anyway. I can see why ED would be an issue but lowered libido?

Even more frustrating, though, is when they don't understand the possiblity of losing cognitive ability. I brought up that paxil reduces word recall. She said that since I was an honors student with a's, it wouldn't matter much if I lost a little mental ability -and since I was so skinny, it wouldn't hurt if I gained 20lbs-. That is part of the reason I don't fully trust the general opinion of SSRIs by doctors. Most people don't seem to think that losing a little mental ability is really a big deal. Maybe they will be a bit more forgetful, but if they can live a normal life, they are happy. Admittedly, like nupi said, this can be well worth it to some people, but it doesn't mean it is worth it to me, and I hate that others feel like they can tell me it will be worth it. At a normal digit span of 6, it is a wonder that I am able to do as well as I do in school; I don't want to push it.


You are worried about cognitive decline and chose Bupropion of all drugs? Wooow.

Edited by nupi, 01 June 2013 - 09:01 AM.

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Also tagged with one or more of these keywords: ssri, serotonin, antidepressant, anxiety, depression, attention, adhd, libido, long term

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