2 replies to this topic

[hadora]

i have just learned that risperidone is an inactivating antagonist at 5HT7 receptors, what does that mean ?,
does it mean that the 5HT7 receptors are shutdown for ever if you take risperidone ?

Anyone ?

[peakplasma]

Hmm... interesting. Not forever, I don't think.

The inactivation is by covalent binding where an irreversible antagonist will wear off eventually at the rate of receptor turnover. Unfortunately, I'm not sure what the rate of deactivation, degradation then synthesis, transport and insertion is... but I'm pretty sure its only pseudo-permanent for a matter of hours to a few days.

Edited by peakplasma, 29 May 2013 - 11:05 AM.

[kevinseven11]

Im assuming this is just a competitive antagonist and a neutral antagonist?