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Equilibrium - Prozium = Nirvana

emotions happiness pain suffering

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#1 Reformed-Redan

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Posted 10 June 2013 - 06:27 AM


I know many people here have seen Limitless. I'm wondering if anyone has seen "Equilibrium?" There was a fictional drug in the movie called, not NZT; but, Prozium.

This drug quelled all emotion in the movie. I am wondering if any such drug exists today that would not hamper cognitive function in any way. I would love there be such a wonder drug. As Schopenhauer stated in his aphorisms, I want to avoid pain and suffering by not seeking that which is pleasurable. In other words, I think, the release from the chains of desire and emotion will lead to a state of nirvana. Is there such a thing as Prozium? Not Prozac; but, Prozium?

Link to full movie if you have free time. It's a good watch. The whole point of Prozium is condensed in the beginning.

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Edited by yadayada, 10 June 2013 - 06:32 AM.


#2 lammas2

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Posted 10 June 2013 - 07:14 AM

So you want to be a human robot?

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#3 Galaxyshock

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Posted 10 June 2013 - 07:53 AM

When my anhedonia was really bad I felt like that. A horrible zombie-like state no emotions no feelings nothing, but my cognition was affected too.. Maybe if it was somehow not so dehumanizing etc. it could be interesting, but I think he human brain is not designed for something like that. You are romanticizing that state like some kind of freedom yet it can be the exact opposite. You don't feel bliss, relief, clarity - you don't feel anything. You are and exist but there is no affect.

Edited by Galaxyshock, 10 June 2013 - 07:56 AM.

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#4 Patrick Sylvester

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Posted 10 June 2013 - 08:53 PM

' class='bbc_url' title='External link' rel='nofollow external'>http://en.wikipedia.org/wiki/Reserpine']
Reserpine (Lannett's Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms...The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings...
Reserpine irreversibly blocks the vesicular monoamine transporter (VMAT). This normally transports free norepinephrine, serotonin, and dopamine from the cytoplasm of the presynaptic nerve terminal into storage vesicles for subsequent release into the synaptic cleft ("exocytosis"). Unprotected neurotransmitters are metabolized by MAO (as well as by COMT) in the cytoplasm and consequently never reach the synapse.
It may take the body days to weeks to replenish the depleted VMAT, so that reserpine's effects are long-lasting.
Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian snakeroot), which had been known as Sarpagandha and had been used for centuries in India for the treatment of insanity, as well as fever and snakebites — Mahatma Gandhi used it as a tranquilizer.
Reserpine almost irreversibly blocks the uptake (and storage) of norepinephrine (i.e. noradrenaline) and dopamine into synaptic vesicles by inhibiting the Vesicular Monoamine Transporters (VMAT).

→ source (external link)


#5 renfr

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Posted 11 June 2013 - 03:22 AM

Prozium is pure evil, I don't understand why would anyone would like to try such a drug.
You should look into antipsychotics, that's what they do but you'll be zombified and cognitive function will be shut down.
Or maybe you can remove your amygdala, it will suppress fear and recognition of emotions.
Chronic alcohol consumption can cause an amygdala shrinkage.
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#6 Reformed-Redan

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Posted 11 June 2013 - 03:48 AM

Prozium is pure evil

Lol, I don't see how you can make that assertion without an object to label it to.

I don't understand why would anyone would like to try such a drug.
You should look into antipsychotics, that's what they do but you'll be zombified and cognitive function will be shut down.
Or maybe you can remove your amygdala, it will suppress fear and recognition of emotions.
Chronic alcohol consumption can cause an amygdala shrinkage.

For reason you have mentioned and must be all too clear; antipsychotics aren't an option.

#7 Dissolvedissolve

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Posted 11 June 2013 - 06:01 AM

When my anhedonia was really bad I felt like that. A horrible zombie-like state no emotions no feelings nothing, but my cognition was affected too.. Maybe if it was somehow not so dehumanizing etc. it could be interesting, but I think he human brain is not designed for something like that. You are romanticizing that state like some kind of freedom yet it can be the exact opposite. You don't feel bliss, relief, clarity - you don't feel anything. You are and exist but there is no affect.


I think you're associating a certain affective component with anhedonia and then conflating that as being part of the state of detachment/"enlightenment" that the OP is describing. There's a serious difference between lack of desire achieved through meditation, awareness training, etc. and lack of desire through anhedonia.

There's absolutely no reason to believe in there being much commonality between these states in chemical or biological terms. I know I've read about increased left hemisphere activation in experienced meditators vs. increased activation in the VMPFC in anhedonia.

I know in my experience, being calm after meditating and being calm due to anhedonic tendencies are vastly different. There's a certain dull, empty, tired numbness to anhedonia versus a tranquil, peaceful, content feeling with regular meditation. OP - I would just start meditating if I were you. It's a slow process and difficult at first, but it's the only way I know of to get at what you're trying to achieve. Some people use drugs (ie serotonergic psychedelics) as shortcuts, but the progress they enable generally fades soon after the drug leaves your system.

Edited by Dissolvedissolve, 11 June 2013 - 06:02 AM.

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#8 brainslugged

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Posted 11 June 2013 - 08:23 AM

I am going to side with renfr here.

I strongly object to destruction of emotion.

Maybe part of it is because of my dabbling in Nietzsche's books when I was in early HS and even more impressionable than I am now, but I think that emotions, good or bad, are very valuable to us. Forgive me if I get pseudophilosophical here.

Are your emotions really that troubling? Is it really that much of a hell inside your head? Sure emotions are troublesome, like a child is troublesome, but I wouldn't kill the child. There are highs and lows, but that is part of being human, am I right? That is part of the experience. You deal with the highs and the lows and work to maximize the highs and minimize the lows. Saying 'screw it' and just throwing it all away, you might as well be dead (don't take that the wrong way). Seriously, without emotions, what purpose is there to live? The only purpose I feel in life is hope of being happy, hope of falling in love, hope of overcoming challenges and coming out of the other side happy. Maybe it is just because I am young and stupid, but I think it is at least worth fighting to the death for.

There are certain aspects of zen/Buddhism (as I understand it, which may not be correct) that I agree with, and certain ones I disagree with. I do believe in what I understand to be the appreciation aspect of zen, to observe everything and appreciate subtleties, etc. However, what is nirvana? Is it just giving in, and being calmly content and kinda happy, like the tired and mildly euphoric state after you eat a large meal and lean back in a comfy chair? There is certainly a time and a place for relaxation and being care free, but it is only in complement to actually doing and experiencing things.

Believe me, I love relaxation. I love, on vacation, to just sit in a comfy chair and drift away, even better if it is near an ocean or lake. But what about the rest of life? Haven't you ever flirted with someone? For the love of god, even I have done that, and I am someone who hasn't even left their house in a month and a half except to go to visit my father. For fucks sake, I have been like this my entire life, barely able to even come up with words around people, alone unless I am at school, and mostly alone even there. I am certain you know what it is like to make the connection, when there is like a lazer between the two of you, and it is like a rythm or something, like the greatest music video to the sound of the world, like the feelings from music, but a thousand times over. And, I mean, that is just one aspect. There are millions of things to experience and explore. Going to Greece, the top of an old acropolis and looking at the mountains around it, holy shit, that feeling where you are like half-crying. And maybe you become disillusioned with the mountains, or the flirting leads to an unhappy marriage, but you do something about it. You find new things that invoke the feelings, you resolve the marriage, even if it means divorce. That is the purpose, and it is what we do. You don't just give it up.

Maybe you accidentally become infatuated with the wrong person. Maybe they hate you, but you just can't get them out of your mind, maybe for a year or a year and a half. But you have to out last it, and there is pleasure even in shit like that. You just have to enjoy the ride, and when you are sick of it, remember in that one sane part of your brain not feeling so incredibly painfully lonely that all the emotions are part of being you. The good times will come. And if they don't then you have enjoyed your struggle.

Why just be a robot in a constant mild state of euphoria? Just do everything automatically? Just go through the motions while you are happily content? That doesn't sound like a plan to me. What about being happy and living forever? What about enthusiasm and discovery? Wouldn't you miss them? Or, maybe a better question since you wouldn't be able to care, don't you want to preserve them like you want to preserve your life? If your emotions aren't you, then what is? Just a cold, objective, organic calculator?

The point of that calculator is to serve the emotions, in a way. We are essentially organic heuristic computers that are self-aware. Maybe we are like a version of Lenat's Eurisko, programmed by evolution to survive, evolving more and more complex systems that help us reproduce until the point that we evolve a system that makes us realize that we don't want to reproduce, we want to live forever, the best way to get the best life is to break the way it works and ignore the evolutionary goal. But it doesn't matter because there isn't some sort of natural imperative to any sort of thing. There isn't a purpose besides the one we have created for our emotions through the screwed up evolution.

Without the emotions, what is really the point? I mean, I guess if you just want to be contentedly mildly euphoric. But there isn't any purpose in the sake of progress or anything. If we kill the scoring system of the heuristic, what is the computer working for? What is the goal then? What good does progress do if you don't have emotions to enjoy it?

A lot of the time, I feel like it is hell inside my head, but maybe I don't really know what hell is because there is always that small part that reminds me it will be okay later, and that suffering is necessary for progress because it implies that there is something to progress for. There must be a way to improve it. There must be a way that I will be able to talk to people and focus right so that I can enjoy things, and I'll be damned if I won't try until I either find a solution or it kills me. I don't think I am alone on this. This is a life extension and medical improvement forum. Isn't our entire purpose to solve the problems, not to just give in? Aren't we here because we don't want to be life's bitch? Otherwise, why not just drown ourselves in lithium and SSRIs and call it a day?

Sorry, I just have a lot of emotions (and I love them to death :3).

Anyway, that movie looks pretty good. Going to watch it probably tomorrow or something. Got a 7.6 on IMDB, impressive enough to warrant my watch.

Edited by brainslugged, 11 June 2013 - 08:31 AM.

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#9 jly1986

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Posted 16 June 2013 - 12:07 AM

Cool movie Equilibrium.
Awesome "gun kata."
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#10 3AlarmLampscooter

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Posted 16 June 2013 - 07:33 AM

One day I was on a combination of Klonopin, Benadryl, Tegretol, Afobazole, Inderal, Latuda and Trazodone. I had basically nothing in the way of emotions, despite going through something at the time that would usually elicit a strong emotional response. I'm naturally not a very emotional person, but this was as damn close to drug induced psychopathy as I've ever been.

Edit: I'd say the majority of the effect was the Klonopin/Benadryl combination with Tegretol. Inderal mostly just stopped any physical response to fear.

Being on Seroquel+Klonopin had a somewhat similar effect, except not as strong and much more sedating.

Edited by 3AlarmLampscooter, 16 June 2013 - 07:42 AM.






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