Mixing nootropics in e-cigarette fluid is absolutely possible. Any chemical is suitable, just so long as it meets a few criteria:
- Must dissolve in PEG40, Propylene Glycol, or Vegetable Glycerin.
- Must be active orally or sublingually in the <50 mg range, the lower the better
- Must have an enthapaly of vaporization higher than the solvent you use
- Should not have a negative reaction when mixed with water for any length of time
- Should not have a very pronounced and easy to achieve "overdose"
- Should not have a very pronounced hangover or withdrawal symptom
Remember, you want the solvent you are using to vaporize, not the chemical it is carrying. The e-cig fluid will "atomize" when vaporizing, forming small particles of itself. The solvents used are generally also hygroscopic, which means that they attract water, and this is the "vapor" that you see. This vapor will encapsulate the chemicals and carry them into your lungs. If the chemical you are trying to use vaporizes, there is no telling what will happen to it's iso-structure, and whether or not it will turn into something inactive or just bad for you. (LSD, for example, would be a bad choice of a chemical to vape. Most of it would turn into iso-LSD, which is basically inactive).
Also, you want to make sure that the dosage that you receive is a good one, and not too powerful. Nootropics which are active orally at <50mg are ideal. As a good rule of thumb, a substance that is vaporized is about 10x more potent than it's oral form, and 5x more potent than it's sublingual form, and will last about half as long. A basic vaping session of e-cig fluid is about 0.25-0.5 ml. You want to have the proper amount of active chemicals in that to equal one dose, at those conversion rates.
To properly mix the chemicals, it is recommended to have a flat-needle syringe and an empty e-cig fluid bottle. Add the dosage of the nootropic to the bottle, put a full syringe of the e-cig fluid in, put the dropper tip back on the bottle, seal it up, and shake it up. Most of it will not have dissolved yet. Now take the syringe, stick the tip of it into the dropper tip of the bottle, turn the bottle upside down, and draw back the plunger of the syringe as fast as you can. This will cause a vacuum to be created in the syringe, will draw out any air or aromatics in the fluid, and will greatly assist in dissolving the powder. Then push the contents back from the syringe once it is full and repeat this process until everything is dissolved. Don't worry if there are a few chunks that do not dissolve, they will occur and are mostly harmless. Now you can add to nootropic e-cig fluid to your vape and enjoy.
I use Sunifiram, myself, at 12 mg/ml in a 12 mg/ml nicotine PEG solution (tropical flavor). The Coconut and Lime intermingles with and overpowers the Suni taste, and gives a very satisfying and mentally stimulating vape.I don't recommend any chemical which has an extremely potent smell, like Noopept, tho. It will make the entire room you are in stink of stale mushrooms and acetone. The negative effects of overdosing make it unsuitable for vaporization, as well.
Edited by Jeoshua, 08 January 2014 - 04:32 PM.