6 replies to this topic

[Even_Smarter]

Hello,

I read several times in the internet that combining racetams with MAOIs could lead to severe brain damage. This is due to Phenylaminoacids or Phenylacetyl (Im not that into chemistry) found in racetams. I also found reports in the internet that this combination leads to pain in the back of the head and in the neck, which actually is not a good sign at all. I experienced that as well, I am using Moclobemide at a low dose. Sadly there is no confident source on the internet to find about this matter.

Another question I wanted to ask is, if anybody knows about Intellimeds.co.uk? I ordered some Pramiracetam and since they do not respond to emails and the substance fully dissolves in water, which it should not although it is forming some kind of oily films in the water, I was wondering if this is real Pramiracetam.

Thanks for your advice

[Tom_]

A full MAOI while its not going to lead to brain damage could lead to severe hypertension or serotonin syndrome (or if you are really lucky both).

Moclobemide however is an MAO-A-I inhibitor not a duel inhibitor of MAO A and B. So its about as safe as combining a racetam with an SS/NRI or NDRI. In other words very safe.

[Even_Smarter]

Thanks thats what I was thinking about too. Secondly it inhibits MAO-A just for 80% and is reversible. Although I dont know what compounds are detoxicated by MOA-A respectively B, but I think B is the crucial one.

[Tom_]

80% inhibition is very high however that and the fact it is reversible doesn't make much difference in this case.

The rest of what you have written doesn't make any sense.

Why is MAO-B the crucial one?

[Even_Smarter]

Because no special diet is required while taking MAO-A inhibitors. Also you just said before that it is safe because it is not a duel inhibitor, so I assume MAO-B is the crucual one. Crucial in terms of removing harmful substances, which is the purpose of monoamine oxidase. At least that is what I thought.

[golden1]

I'm positive I've taken at least aniracetam and piracetam while on deprenyl(mao-b inhibiting dose only).
Didn't seem to be any interaction.

[Tom_]

I follow you now. No, only when you combine both an MAO-A and B or duel inhibitor does the combo become significantly risky (requiring some diet changes and being careful when it comes to polypharmacy).