22 replies to this topic

[revenant]

I am going to be 46 in 2 weeks

[revenant]

^{take your carnosine ...no joke}

[sthira]

^{take your carnosine ...no joke}

Does beta-alanine elevate tissue carnosine levels?

[N.T.M.]

^{take your carnosine ...no joke}

From what I've read about it, there doesn't appear to be any risk of toxicity, even at very high doses. I've been taking 500 mg/day, but I've been thinking about increasing it. How much do you take?

[revenant]

I actually take 1500mg per day, but I eat vegetarian and like a bit of refined sugar and seared/fried tofu.. so I may need more.

[revenant]

^{take your carnosine ...no joke}

Does beta-alanine elevate tissue carnosine levels?

I think that if L-Cystine levels in the body are sufficient, it is likely. I have not looked around for studies that demonstrate this. I wouldn't want to risk not getting adequate carnosine though. FWIW, I do take a week off from carnosine every 6 weeks, trying to be safe...completely arbitrary.

[revenant]

Oh also, if you don't take L-Carnitine supplements, methylene blue, and vitamin-E as well, have been shown to slow/perhaps preclude the deposition of lipofuscin, which carnosine consumption seems to compound.

[N.T.M.]

Oh also, if you don't take L-Carnitine supplements, methylene blue, and vitamin-E as well, have been shown to slow/perhaps preclude the deposition of lipofuscin, which carnosine consumption seems to compound.

Am I understanding you correctly? You said that carnosine accelerates the accumulation of lipofuscin? I'd say that's quite a drawback.

Could you possibly refer me to any sources? Also, have you read anything about taking carnosine at higher doses, like what you're taking?

[revenant]

Am I understanding you correctly? You said that carnosine accelerates the accumulation of lipofuscin? I'd say that's quite a drawback.

http://www.researchg...-ageing_peptide

Article
Carnosine, a protective, anti-ageing peptide?



A R Hipkiss

Molecular Biology and Biophysics Group, King's College London, Strand, UK.The International Journal of Biochemistry & Cell Biology (impact factor: 4.63). 09/1998; 30(8):863-8.
Source: PubMed



ABSTRACT Carnosine (beta-alanyl-L-histidine) has protective functions additional to anti-oxidant and free-radical scavenging roles. It extends cultured human fibroblast life-span, kills transformed cells, protects cells against aldehydes and an amyloid peptide fragment and inhibits, in vitro, protein glycation (formation of cross-links, carbonyl groups and AGEs) and DNA/protein cross-linking. Carnosine is an aldehyde scavenger, a likely lipofuscin (age pigment) precursor and possible modulator of diabetic complications, atherosclerosis and Alzheimer's disease.

Could you possibly refer me to any sources? Also, have you read anything about taking carnosine at higher doses, like what you're taking?

I know that beef contains about 1,500mg per pound. I used to eat that much in a day sometimes, not often, but sometimes. I take breaks from carnosine because I have not found any research concerning the absolute safely of taking that much continuously for prolonged periods. My worry is developing an acute carnosinase deficiency. I don't know if that is possible, or if it could be dangerous. I have not found any studies that demonstrate that carnosine supplements can cause a carnosinase deficiency. Nor have I read about any persons ever being seriously harmed by carnosine. Of course if one had the rare genetic mutation that precludes carnosinase production, then carnosine supplements would definitely be off the table.

I only started taking 1500 mg daily about 6 months ago. Before that, since about 2004, I have been taking 1000mg daily. I have noticed only good health effects so far. I particularly notice good skin and hair. Also, I used to have chronic pain in my one of my knees, but that has been gone for about 5 years now.

You are wise to question taking large doses of anything. I have always been a bit zealous about taking supplements that I think are important (yet I am still mousy about taking any C60/oo). Carnosine though is very protective. I think even 500 mg is doing you a lot of good.

[Julia36]

we scratch at the dge of biochemical supplements. The interactions are not possible to comprehend nor configure until machine intelligence breaks in about 2022, IMO.

But massively important is.

1. All of us are different. What works for me could kill you.

2. Foods have been tried over centuries.

3. Drug interactions have to be studied before taking anything.


It is boring that we may still be too early to use many supplements.

I use lef.mix and have looked for about and hour on google scholar and others on carnosine.

It looks good, but it may not be.

I've taken lef.org mix much of the time over 20 + years, and just started alternate fasting days of 600 calories/eat anything.

The results of fasting are good.

The results of lef mix were brilliant for the first weeks (ie I noticed the great effects).

Compared to my sibblings who take no supplements but have excellent nutricious diets I dont appear to have any edge, although they maintain healthier lifestyles than me, and use music heavily which has been shown to de-stress mitochondria (I've just searched for a ref but cant find it):

Exercise is v important as well.

[1kgcoffee]

Maybe it's not showing, but can you post a picture for us?

[N.T.M.]

I know that beef contains about 1,500mg per pound. I used to eat that much in a day sometimes, not often, but sometimes. I take breaks from carnosine because I have not found any research concerning the absolute safely of taking that much continuously for prolonged periods. My worry is developing an acute carnosinase deficiency. I don't know if that is possible, or if it could be dangerous. I have not found any studies that demonstrate that carnosine supplements can cause a carnosinase deficiency. Nor have I read about any persons ever being seriously harmed by carnosine. Of course if one had the rare genetic mutation that precludes carnosinase production, then carnosine supplements would definitely be off the table.

I only started taking 1500 mg daily about 6 months ago. Before that, since about 2004, I have been taking 1000mg daily. I have noticed only good health effects so far. I particularly notice good skin and hair. Also, I used to have chronic pain in my one of my knees, but that has been gone for about 5 years now.

You are wise to question taking large doses of anything. I have always been a bit zealous about taking supplements that I think are important (yet I am still mousy about taking any C60/oo). Carnosine though is very protective. I think even 500 mg is doing you a lot of good.

Thanks for the information. And I'm a little unsure about taking C60, too. It seems like taking the wrong kind, or not using the correct delivery mechanism, can result in brain damage. Scary stuff.

[revenant]

Maybe it's not showing, but can you post a picture for us?

Well, I'm going to really regret this when the deathists' brownshirts start rounding us up. But here you go, don't hate me.

[ben951]

To me you look younger then 46 more like someone in his late thirties.

I'm 40 and I noticed that I tend to look younger when I'm a bit overweight even though I'm in a better shape and have more energy when I'm thin.

[N.T.M.]

You look excellent, Revenant. Definitely not like a 46-year-old.

[forever freedom]

You're in good shape. I'd say late thirties too.

[Julia36]

Good one.

I think it is possible to slow aging. I'm using ADF, discounting the 2010 paper which showed it killed rats, because they were completely deprived food on alternate days and not 50--600 calories plus vits and minerals on ADF.
big callenge.

Important to get bio markers accurately measured.

It cant ever be to do with face.

A colleague of mine is 56 and he looks 38 but he has stayed out of any sunlight for 30 years and has ultraviolet screens in his apartments.

Genetics are presently pretty dominant. Then supplements.

Then exercise.
Then stress levels.
Then socialising/lifestyle.
Having people clapping whereever you go in public is very helpful.

I refuse to use moisturiser/deorederant etc they are obviously going to act against the body.

Many of us do things regarded as eccentric by society.

I take air baths like Bemjamin Frankin (died aged 84),

but am a night owl and can work for 2 days.


To turn SIRT1 on is a

[Lightflow]

You look like you're in a good shape, but that's just what it is - shape, health. Maximum lifespan is still genetically predetermined, isn't it? Talking about telomere study for example. I'm new here, so feel free to point out how ill informed I am.

[revenant]

You look like you're in a good shape, but that's just what it is - shape, health. Maximum lifespan is still genetically predetermined, isn't it? Talking about telomere study for example. I'm new here, so feel free to point out how ill informed I am.

Oh good! Now I get to blather narcissistically about my supplements etc. Here are some of the things I am worried about and what I do to protect myself.
Hayflic limit: strong homemade Astragalus tincture (about 8 oz per month), carnosine, vitamin D3, vitamin C, other antioxidants

AGES: carnosine, aspirin (inhibits formation of pentosidine), cycle ho shou wu /2,3,5,4 tetrahydroxystilbene glucoside (inhibits formation of pentosidine), good diet

Mitochondrial DNA attrition from ROS: methyleneblue, alpha lipoic acid, red ginseng (methionine sulfoxide reductase expression), hoping MitoSENS type research can save our mitochondria

mTOR/DAF-1/FOXO: reishi, acetic acid, exercise, hoping for effective gene therapies

Endogenous antioxidant decline: gotu kola (upregulation of catalase, SOD, glutathione redox) , carnosine (salvages SOD), NAC (catalase, and glutathione), daily exercise increases levels of endogenous antioxidants through hormetic pathways

Extracellular/intracellular aggregates: carnosine, methyleneblue, vitamins C and E, hoping for effective proteome therapies and antibody vaccines

[Lightflow]

Oh good! Now I get to blather narcissistically about my supplements etc. Here are some of the things I am worried about and what I do to protect myself.

Thanks, you gave me a lot to google about.
Can you please tell how long you think this can prolong your life? Let's say if any tech-progress stopped and you did what you do atm for the rest of your life?

[revenant]

Oh good! Now I get to blather narcissistically about my supplements etc. Here are some of the things I am worried about and what I do to protect myself.

Thanks, you gave me a lot to google about.
Can you please tell how long you think this can prolong your life? Let's say if any tech-progress stopped and you did what you do atm for the rest of your life?

Without SENS type therapies in the formula -and I know this is going to sound deluded- I am hoping for an extra 35 years of health-span beyond the average. This is probably an optimistic and mostly an arbitrary estimation, but I have to be optimistic, otherwise I wouldn't be doing this every day. I have seen some really good results so far. I'm in absolutely perfect health according to my physician. I look and feel the same as I did 10 years ago. A little better maybe. I am really hoping that C60/oo turns out to be unquestionably safe.

[revenant]

I'm using ADF

ADF as in alternate day fasting? If so, would you mind elaborating on your experiences a bit.. please?

[N.T.M.]

I am really hoping that C60/oo turns out to be unquestionably safe.

Yeah, I've been waiting for the same thing.