2 replies to this topic

[geo12the]

I have a couple of questions. I apologize in advance if they are redundant and have already been discussed, I am trying to wrap my head around the C60 thing.

• I came across this paper http://www.ncbi.nlm....pubmed/11331193 where they saw positive effects of fullerenes in aqueous solutions. How important do people think it is that they are dissolved in olive oil?

• Olive oil is known to have phenolic compounds like hydroxytyrosol that have health benefits. Could there be some kind of synergistic interaction between these compounds and C60?

• Any potential bad interactions of taking C60 with things like fish oil, resveratrol and curcumin? Best time of the day to take C60?

Edited by geo12the, 16 September 2013 - 09:55 PM.

[niner]

I think that the olive oil is very important. The c60 isn't just dissolved in the oil, it reacts with it to form a new compound, a c60-fatty acid adduct. I think the c60-fatty acid adduct then gets incorporated into membranes, including mitochondrial membranes where most Reactive Oxygen Species are generated. People have reported a lot of favorable biological activities with a variety of molecular (ie, non-aggregated) fullerene species, including pristine c60 that has been forcibly inserted in water as a hydrated molecule (Andrievsky's work), water soluble analogs like Laura Dugan's tris-malonates, and the fatty acid adducts of Baati et al.

I don't see a mechanism for synergy between olive oil polyphenols and c60. The effects are probably additive.

I don't see significant interactions between c60-oo and typical supplements. I'd probably keep fish oil away from it, given C60's ability to react with various fatty acids. I don't think the time of day matters at all, since the half life of the compound in membranes is extremely long. I dose it once a month.

[hav]

That's a fairly old abstract. 2001. Seems to be commentary on another previously done study but that's not absolutely clear from the abstract. It seems to deal with a pretty limited subject of malonic acid c60 adducts, carboxyfullerenes, to treat cell cultures with limited in vivo data treating familial amyotrophic lateral sclerosis (FALS) in mice. I think this 1997 study may be what its referring to:

Carboxyfullerenes as neuroprotectiveagents (full-text)

It found a 15% delay (8 to 10 days) in the death of mice genetically predisposed to FALS when treated with carboxyfullerenes. But no data on life extension of healthy mammals.

Howard

Edited by hav, 16 September 2013 - 11:20 PM.