According to the limited amount of Russian literature that's been made available, the typical dose for picamilon is 50mg 3X daily for a total of 150mg/daily but doses up to twice that are sometimes used. Discontinuation is recommended after 1-2 months, again according to russian literature advising physicians on proper usage. I have no idea why the discontinuation is recommended.
CDP choline should be taken with at 1-2 grams (1,000-2,000mg) daily, but sometimes doses as small as 500 mg/daily are used. You'll gain many benefits if you add fish oil to this to get the DHA (search Choline, uridine and dha on longecity to find out why), since CPD choline is a prodrug for uridine (in humans) and choline.
IIRC ~165mg Bacosides daily is the standard dose to achieve its proven effects r.e. cognitive enhancement, so it will depend on the % bacosides your supplement is, although some (myself included) use doses much higher than that. You might want to increase the dosage to suit your needs. Bacopa does decrease sperm motility a good amount but has no effect on libido, testicle size or testosterone levels. You will see some sensationalist posting on this forum about the downsides of bacopa. The claims are very overblown and have no scientific basic, just paranoia. Bacopa has more evidence behind enhancing memory in healthy people than any other supplement we can buy, that's not to say it will be the most potent nootropic, just the most proven in people without any cognitive decline. This is an accumulative effect and takes 1-3 months to manifest, you will not notice the memory enhancement right away. Anxiolytic effects are felt right away though.
If you got the cash to burn, Kava is the most potent of the non-addictive anxiolytics, but there is some slight concern over LONG-TERM use and pre-existing liver conditions, doesn't seem to make a good match for the extremely rare case. It's also been proven to help restore GABA-A fuction/density, cant say whether or not that will do much for you though.
In personal experiences, I sometimes combine 300mg 'Cyracos' Melissa Officianalis extract with Lavender Essential oil aromatherapy for anxiolytic effects and CRAZY dreams. Valerian should help (commonly paired with melissa) but I cant say so from personal experience. The lavenderXmelissa synergy is purely theoretical and hasn't been proven
in vivo, only
in vitro, but from personal experience the synergy is there and very potent. To use lavender for aromatherapy just get some essential oil and a q-tip, dip one end of the q-tip in the oil and place it as close to your pillow as possible. You can use the melissa as aromatherapy as well instead of the Cyracos standardized extract and just dip the other end of the q-tip in it so you have lavender on one side and melissa on the other. For daily aromatherapy use you could stick the q-tip behind your ear.
Melissa officinalis L. has been shown as an anti-stress and anxiolytic agent. We previously reported moderate stress improvement in mice in which Cyracos(®), a standardized Melissa officinalis L. extract, was administrated. Cyracos(®) contains phytochemicals that inhibit gamma-aminobutyric acid catabolism. This was a prospective, open-label, 15-day study to evaluate the efficacy of Cyracos(®) on stressed volunteers, who have mild-to-moderate anxiety disorders and sleep disturbances. Using clinician rating criteria, primary outcomes showed improvement of symptoms. Cyracos(®) reduced anxiety manifestations by 18% (p < 0.01), ameliorated anxiety-associated symptoms by 15% (p < 0.01) and lowered insomnia by 42% (p < 0.01). As much as 95% of subjects (19/20) responded to treatment, of which 70% (14/20) achieved full remission for anxiety, 85% (17/20) for insomnia, and 70% (14/20) for both. Our study demonstrates, for the first time that chronic administration of Melissa officinalis L. relieves stress-related effects. It is critical that further studies incorporate a placebo and investigate physiological stress markers.
http://www.ncbi.nlm....pubmed/22207903Both Melissa officinalis (Mo) and Lavandula angustifolia (La) essential oils have putative anti-agitation properties in humans, indicating common components with a depressant action in the central nervous system. A dual radioligand binding and electrophysiological study, focusing on a range of ligand-gated ion channels, was performed with a chemically validated essential oil derived from La, which has shown clinical benefit in treating agitation. La inhibited [35S] TBPS binding to the rat forebrain gamma aminobutyric acid (GABA)(A) receptor channel (apparent IC50 = 0.040 +/- 0.001 mg mL(-1)), but had no effect on N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) or nicotinic acetylcholine receptors. A 50:50 mixture of Mo and La essential oils inhibited [3H] flunitrazepam binding, whereas the individual oils had no significant effect. Electrophysiological analyses with rat cortical primary cultures demonstrated that La reversibly inhibited GABA-induced currents in a concentration-dependent manner (0.01-1 mg mL(-1)), whereas no inhibition of NMDA- or AMPA-induced currents was noted. La elicited a significant dose-dependent reduction in both inhibitory and excitatory transmission, with a net depressant effect on neurotransmission (in contrast to the classic GABA(A) antagonist picrotoxin which evoked profound epileptiform burst firing in these cells). These properties are similar to those recently reported for Mo.
Edited by Dizzon, 27 November 2013 - 01:50 AM.
