Thanks for the response!
If this is the case with Pyrinitol and Sulbutiamin then both products are SCRATCHED OFF the list.
Yeah, I should also mention their both just two B-vitamin compounds bound together (Pyrinitol being two B6 compounds, Sulbutiamine two B1 compounds), which are likely cleaved apart in the brain and other organs into just plain old B-vitamins. Now, this doesn't mean they have no uses; they both penetrate the blood-brain-barrier much more efficiently than standard B vitamin preparations. I suspect they'd be beneficial in rapidly correcting respective B vitamin deficiencies. They may also have a use in correcting depleted levels of Vitamin B in the CNS, when systemic levels are normal (what circumstances would produce a specific depletion are unknown to me). They also seem to be neuroprotective and neurorestorative properties (rescueing damaged neurons), but this only seems useful in treating organic brain damage, either disease or trauma induced. There are better neuroprotective compounds for just preventing general age decline.
I totally want to remove l-tyrosine (possibly 5-htp) and NADH
and replace it with the best MAO-B Inhibitor. Like Deprenyl
but I need to find the best non-controlled substance of this.
I would honestly advise against MAO inhibitors for cognitive enhancement. They might be useful as a last ditch effort for ADHD issues, but in healthy individuals they aren't worth the risk. You need to be verrry careful with your diet with some irreversible MAO-inhibitors (the common ones are), and even in reversible inhibitors I would not combine them with a huge nootropic stack, as it would be too difficult to predict interactions. You could possibly have a hypertensive attack if something increased monoamine levels while you were simultaneously inhibiting the enzymes designed to keep them in check.
For a college student, who I presume may have irregular sleep schedules (woo for the college life;) ), modafinil would be a much better replacement for a MAO-inhibitor. It'll likely produce the same effects you're looking for (increased alertness, decreased sleep-related fatigue), without the risk. It's actually a great compound with a minimal risk profile (just stick with a lowish dose). Very little tolerance, no addictive properties (minor discontinuation syndrome if you abruptly stop taking it, but probably not as bad as caffeine's). There a few of different versions of it (modafinil, armodafinil, adrafinil), I would go for armodafinil if you can afford it, it's the pure active isomer of modafinil, so it has a more steady pharmokinetic profile. Adrafinil is an extended release version, but it can produce hepatotoxicity with chronic use due to putting stress on the liver to metabolize it (do not take Adrafinil for more than a month without a liver enzyme panel to check for distress). Pure old modafinil is the easiest to get, but tends to have high peaks and valleys in the pharmokinetic profile.
I'm wondering what the long-term effects with inhibition of MAO-B receptors.
If I cannot find anything, I will make a new topic on this.
MAO A/B are not receptors. They are enzymes that metabolize various neurotransmitters (dopamine, serotonin, etc). Along with COMT enzymes, they keep neurotransmitter levels in check (though they can still be overridden by large surges of neurotransmitters, such as that produced by MDMA). Inhibiting them slows down the various neurotransmitters metabolism since it puts all the work on COMT enzymes.
The only problem I have with the newish Racetams are that they have very little studies, and the ones that are studied are typically only found by individuals on Longecity, etc.
That's a valid concern, especially for the extremely vague racetams like Unifiram. It should be noted several members have used them regularly for months with no apparent negative effects, but if you'd rather not take the risk that's fine.
I will always consider Noopept, but I am trying to create a universal stack so that maybe 8 out of every 10 students will find many benefits when using my product.
and unfortunately there are many cases that noopept creates brain fog the first time using this product and long-term use if found to increase anxiety.
The brain fog effect is pretty valid, a lot of people do experience brain fog the first few days, though I would mention a lot of those people were trying crazy doses. A good starting dose is 10 mg, which is unlikely to produce signifigant negative effects, as it's at the bottom of the therapeutic index. I use 20 mg, and as a 160 lb male I experience no negative effects.
The anxiety effect should not be common, as Noopept has actually been observed (in clinical studies) to be anxiolytic, it prevents spikes in hippocampal activity associated with stress.
However, my mind is beginning to accept certain inhibition suppliments like Deprenyl, therefore opening my eyes up to other inhibiting suppliments such as Huperzine A.
Huperzine A seems to be the only suppliment I could find that specifically increases short-term memory ability other than Piracetam.
I would much rather use CDP Choline or Alpha GPC to increase choline. But is there a good chance that Huperzine A might have more beneficial effects towards short-term memory as apposed to one of these more premium Choline sources?
I would not use Huperzine A. Like MAO-inhibitors it raises acetylcholine levels through the inhibition of acetylcholinesterase, the enzyme in charge of metabolizing acetylcholine. The fact this enzyme so efficiently controls acetylcholine levels is likely the reason why many of the racetams can be taken at extremely high doses without dangerous side-effects (besides head aches, brain fog, and muscle tightness). Inhibiting it opens up the possibility of acetylcholine rising to dangerous levels.
I would point out that nerve gas, a chemical weapon works in the same way, blocking acetylcholinesterase, causing increased cholinergic activity, which at low doses produced distress, and large exposures, death from asphyxiation. I would really not mess around with Huperzine because of this. Additionally, a lot of members experienced a bunch of side-effects like depressed mood, brain fog, etc.
CDP-choline would be a good supplement, it's a good choline source. Alpha-GPC has been less studied, but seems to be even more efficient. However I've found it to be more expensive and not worth the cost.
Edited by GetOutOfBox, 19 November 2013 - 08:21 PM.
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