Hey all,
First time post here. Sorry if this is a little different from the usual stuff, but I didn't know where else to post this. Judging from my months of lurking around here, it seems you guys are generally more scientifically knowledgeable about this stuff than peeps on other websites, so I thought I'd give it a shot. I'm currently prescribed Accutane (technically isotretinoin, Claravis is the brand, but saying Accutane is just easier) and Vyvanse, 40mg a day for both of them, though I often take the Vyvanse in the range of 80mg if I have a paper I need to finish (college student). Anyway, I got on the herbal supplement bandwagon for general health and longevity before being prescribed either of them and decided to continue the supplements to counteract many of the negative side-effects from both medications. However, I'm concerned that they might be interfering with the efficacy of the Accutane or creating unhealthy chemical imbalances with the Vyvanse.
I currently take:
500mg of Green Tea Complex (225.5mg total polyphenols, 125mg of which is explicitly labeled as EGCG)
100mg of Grape Seed Extract (95mg polyphenols)
250mg of Pomegranate Extract (100mg Ellagic Acid)
(All GNC Brand, 1 per day)
I take these everyday, regardless of whether or not I take the Vyvanse. Sometimes I do take them concurrently. However, I always take my Accutane about 3 hours before or 3 hours after any other supplements/vitamins. I'm specifically worried that the pomegranate may be affecting the absorption of the Accutane, due to pomegranate's ability to inhibit certain enzymes in the liver, which may overlap with the same enzymes used to process Accutane. Moreover, I know MAOI's and amphetamines shouldn't be mixed, but are any of the listed supplements truly potent in their capacity to create a negative effect? And if so, what would that effect look like? Can I still take them at the same time or only when I'm not on Vyvanse? For whatever reason, my mind has been fixated on this lately, so any insight here would be massively appreciated.