2 replies to this topic

[BigKev]

The ones I've heard about are Caffeine, vits B12 & D, Resveratrol and R Rosea. I just got a couple raw ingredients for testing and I'm very interested to hear about experiences of members here.

Anyone here can share their experience in attempting buccal absorption? (Onset timing, dosing, dosing change due to buccal abs., effects change, by-products, pathways, etc...) Also looking for literature and posts (here or even redditt ;-)

Cheers,
K

Attached is the list I have a lot of interest for.

List

Rhodiola Rosea
Green Tea Extract
Huperzia Serrata
Korean Ginseng Extract
Bilberry
Oat Straw
Grape seed extract
Alpha GPC
L-Theanine
L-Tyrosine HCl
Alpha Lipoic Acid
Bacopa
Vinpocetine
Eleuthero Extract
Beta-Alanine
Choline Bitartrate
L-Arginine Base
Acetyl L-Carnitine (ALCAR)
DMAE-Bitartrate
N-Acetyl L-Cysteine (NAC)
Ginkgo Biloba Leaf Extract
N-Acetyl L-Tyrosine (NALT)
L-Tyrosine
L-Arginine a-Ketoglutarate (AAKG)
L-Citrulline DL-Malate 2:1
Longjack Extract 100:1
D-Ribose
Branch Chain Amino Acids (BCAA)
Hyaluronic Acid (Na Hyaluronate)
Tribulus Terrestris
Curcumin 95% Natural Turmeric Extract
Grape Seed Extract
Green Tea Pure Extract 50% Caffeine
Green Tea 50% Polyphenols
Gamma Aminobutyric Acid (GABA)
Coenzyme Q10 (COQ10)
Phenylethylamine HCL (PEA)
N,N-Dimethyl Glycine HCL (DMG)
L-Tryptophan
L-Methionine
Quercetin Dihydrate
Para-AminoBenzoic Acid (PABA)
Taurine
R-Alpha Lipoic Acid (R-ALA)
Spirulina
Ascorbic Acid (Vitamin C)
D-Aspartic Acid (DAA)
Whey Protein Isolate 90%
Potassium Citrate
Glutathione Reduced
Magnesium Glycinate
Sucralose
Stevia
Vitamin B3 (Niacinamide)
Chlorella Blue-Green Algae
Inositol (Vitamin B8)
Vitamin B12 1% (Cyanocobalamin)
Niacin (Vitamin B3)
Betaine Anhydrous Trimethylglycine (TMG)
Vitamin D3 (Cholecalciferol)
Potassium Chloride
MSM (Methylsulfonylmethane)
L-Citrulline DL-Malate 1:1
Vitamin B6 (Pyridoxine HCL)
Zinc Gluconate
DL-Phenylalanine
Vitamin E
L-Ornithine HCL
L-Methionine
L-Lysine HCL
Glycine
Thiamine HCL (Vitamin B1)
Pine Bark Extract
L-Proline
Thiamine Mononitrate (Vitamin B1)
Magnesium Carbonate
Maca Root Extract 4:1
L-Carnosine
Biotin 1% (Vitamin B7)
Guar Gum
Lutein
Hoodia Gordonii
L-Isoleucine
Beta Sitosterol (Plant Sterol)
Nattokinase
Cinnamon Bark Extract
Rutin
Potassium Gluconate
L-Alanine
L-Histidine HCL
White Willow Bark Extract
L-Threonine
L-Aspartic Acid

[jadamgo]

Bump. I had a hard time finding much information about buccal absorption; any help would be appreciated.

What I know so far is that small uncharged molecules are usually the best candidates, especially if lipid soluble and also at least a little water soluble. The smaller the better.

Also, the required dose should be low enough for sublingual use to make sense. A 10mg dose of noopept is a tiny amount of powder, easily and rapidly absorbed despite being a large molecule simply because it's such a small amount of substance, and also, whatever gets swallowed will still be absorbed lower in the digestive tract anyway. But a 4g dose of piracetam would be useless because it would take forever to absorb. (Plus, that taste -- God!)

The problem is that those rules don't explain everything. Zaleplon, for example, should be a great candidate. But it isn't. Trying to take it sublingually is a waste of time because it simply won't absorb well until it's gone past the stomach. Why is this so? I can't figure it out yet.

[BigKev]

Bump. I had a hard time finding much information about buccal absorption; any help would be appreciated.

What I know so far is that small uncharged molecules are usually the best candidates, especially if lipid soluble and also at least a little water soluble. The smaller the better.

Thanks for the bump, I dind't find a topic focused on buccal absorption elsewhere.

To build a bit more on the topic, the reasons I'm researching on this is to increase onset rate & bioavailability while decreasing degradation (stomach, gut, hepatic, etc).

The usual thumb rule is better absorption with compact molecules and small dosages.