This is in response to the topic mentioned several days earlier, which found that social interaction is dependent upon some complex response of the nucleus accumbens in social situations.
However, elevating dopamine alone does not appear to be the answer: it seems to also be rooted in raising GABA.
I've done a fair bit of research around this topic, and my findings are that substances which positively affect the benzodiazepine receptors of the GABA complex, appears to be quite unique in causing behavioural disinhibition. Interestingly, Ginkgo Biloba which was found to inhibit some of the GABA-A receptors, was found to decrease social contact when administered alone.
So, if you're a ''person of few words'', and haven't responded greatly to SSRI's or dopaminergic substances (Rhodiola, Chaenomeles), then it may be worth looking at substances which positively affect GABA signalling.
BUT, that does not mean going straight for classic benzo drugs, as their effects quickly disappear and tolerance builds. My first guesses would be instead to try the amino acid ''GABA'', or ''Picamilon'' which may have a better chance of reaching the brain.
This might all be a load of rubbish, but I am no expert. This is simply a theory.
Edited by agwoodliffe, 21 February 2014 - 12:48 PM.