7 replies to this topic

[casinelli26]

Hi everyone,

I've been a member of this community for a few years, but this will be my first post!

Anyways, I have a somewhat brief experience with nootropics in the past and I recently decided to experiment with noopept. Before going into my question, I want to provide some background info on my past experience and why I chose to try noopept. I just graduated from college but while I was there, I chose to dabble a little with stimulants (adderall). I was given a prescription by my psychiatrist for ADD, 10mg 3x a day. My use with this medication was sporadic and was correlated with the amount of work I was given at the time. Getting straight to the point, there were all nighters that resulted in excessive use to keep me awake when cramming was necessary. I'm talking multiple 48 hr periods with dosages in the range between 100mgs-200mgs. It was very irresponsible I know, and I'm also well aware of the neurotoxic effects that stimulants have on the brain. I stopped using stimulants around 6 months ago as I realized this was poor way to function in life and I was robbing my future self of energy.

This lead me to search into noopept. I've done my obligatory due diligence in researching the chemical and other user experiments, but I'm no where well versed enough in scientific terminologies used to understand everything that I have read. I chose to start slow and experiment with this chemical 4 months ago, and for a month I would dose 30mg 1x a day. The effects were not profound, but there was certainly 'something' happening and those who have felt it before know what I'm talking about. After my supply ran out, I chose not to re-order more because didn't feel the need to. Fast forward to now, out of curiosity I decided to experiment with the chemical again. This time I ordered it in powder format and use a mg scale to measure my dosage. I know the suggested use is 15-30mg a day. My usage has been varying anywhere between 30mg to 90mg a day for no specific reason other than experimentation and to see how different dosages affect my perception. I unfortunately haven't established any metrics to measure these effects and therefore it's all subjective so I'm going to leave it at that. I do feel however that 'something' going on.

Now what lead me to create this post is I am trying to gain a better understanding of this chemical, its long term affects, and how others have reacted to it. From my research on this forum and over the internet, there appears to be a wide range of user experiences from the extreme positive life changes to no differences felt and to the extreme at the opposite end of the spectrum, depression and derealization. I think I may have picked up on a pattern though, but uncertain if its due to the frequency of me searching this particular topic, but there seems to be a positive correlation between negative symptoms as a result of noopept use and the duration which one has used noopept. Again this is more subjective than factual base as I cannot present to you actual statistical figures, but what inspired me to write this was the chemical's review on examine.com. I came across this excerpts

"0.01mg/kg injections of Noopept for 21 days in rats has failed to increase memory in otherwise healthy rats, but appeared to restore memory in rats subject to a bulbectomy (removal of olfactory bulb).[20] "- http://examine.com/s...ements/Noopept/

"One rat study has noted that, similar to Piracetam, administration of Noopept to otherwise healthy rat pups (8-20 days of age) results in an impairment of memory formation (declarative and procedural) without influencing locomotion.[30]"- - http://examine.com/s...ements/Noopept/

So in summary it looks that noopept appears to be an effective tool used to treat a brain that has received some damage whether it be oxidative stress or excitotoxicity, but otherwise healthy brains receive no positive benefit from noopept use and if anything, the study showed they suffered negative effects of memory impairment. This lead to me to hypothesize that noopept does work well when first administered to someone who has undergone some type of damage to their brain, but as the brain goes back to its normal executive functioning level, noopept use could actually be detrimental. This theory makes sense to the reasoning why someone initially benefits from this drug but long term use does not provide the same benefit as the first few doses. Thus, should noopept be used more as a treatment aid than a supplement aid?

For those who have read this far, thanks. I just wanted to get a feel on what others thought about this subject since this chemical is certainly potent and not something to mess around with. If anyone has other links and research studies (that can be understood in basic english), or want to share their experiences, I would love to read them.

[Strelok]

Hmmm, might be onto something.

I took Noopept for 2-3 months, about 10mg twice daily. I did this because it is the suggested dosing from the manufacturer. I usually mixed it in with my coffee. I would notice that it would give me an anxiolytic effect, in spite of the caffeine from the coffee. I don't really have an anxiety problem, but it did seem to make it easier to talk to strangers...

I started a washout period months ago. I had initially planned on only doing 1-2 months of washout, but never got around to adding it back to my stack. The washout period turned out to be over 6 months. It seems that any benefit that I had originally got from it (anxiolytic) has vanished. But maybe I just got used to a different baseline.

Anyway, i just started talking it again 2 days ago. Per manufacturer recommendations, I'm going to take it for 1 month, 10mg twice daily. Impairment of declarative or procedural memory is definitely something I want no part of. If anything, I specifically want to enhance those areas of my memory. I hope my memory hasn't gotten worse from without me noticing. I'd guess not, though.

[casinelli26]

Thanks for responding, I was beginning to think no one would. In regards to your comments on memory, when reading through other user experiences, they did notice that their short term spatial memory was affected. There was a correlation between higher dosage and memory issues. The paradoxical thing about memory is that it's sometimes difficult to tell you are forgetting things if you can't remember them in the first.

In my own personal experiences, I haven't noticed any deterioration in with memory, and I suppose I could say my long term memory retention may have improved. Then again, this could all be subjective or a placebo effect. It's frustrating that there is no simple way to measure the effects of this drug. On that note, I did briefly read through a journal log that used complex statistical measurements to see if noopept worked or not. The data was too complex for me to understand or even follow. I don't have the source on me now, but if you or anyone is interested I can dig it up.

[mrd1]

Ive been consuming 140 mg daily now for a few weeks and have been using noopept at various dosages and frequencies for months. Perhaps it is because the effects of noopept are bimodal that some people have issues. Bimodal just means two peaked and it worked out for me to like 8mg-10mgish or 135-140 mg. With the second peak being about twice as effective at bringing the sample of rats to baseline I believe.

[BigJohn]

Do you think that any adverse effects would apply to aniracetam or oxiracetam (which I currently take on a daily basis)? Why do you hypothesize that noopept or any race tam would have adverse effects on an already healthy brain? There are studies out there that claim to support the hypothesis that nootropics (racetams in particular) can impact healthy brains positively, and studies have shown that racetams are neuroprotective, which would lead me to believe that they have no potential to damage the brain in any way. By the way, I too, have heard sketchy things about noopept which led me to stick to the more well known and researched nootropics such as oxiracetam and aniracetam.

[casinelli26]

BigJohn, I cannot speak for aniracetam or oxiracetam as I have yet to do any of my own research into these chemicals or have tried them. I've only tried Piracetam and this was a little over two years ago. My hypothesis only applies to noopept and none of the racetams, theoretically noopept is not even a racetam> "Noopept is not technically a racetam molecule (due to not having a 2-oxo-pyrollidine skeleton), but is generally grouped together in the same category"- http://examine.com/supplements/Noopept/

While I have no doubt that noopept benefits the brain in a positive way, it was my research into user experiences that lead me to dig deeper into the long term effects of this chemical. Some users have had drastic negative experiences with noopept such as http://www.reddit.co...here_have_this/

The comments in this thread are more in terms of the efficacy of the chemical diminishing after being used for the first time or few times afterwards and not over a longer period.

I came across this post on http://www.longecity...has-changed-me/ which I suppose inspired me to start digging deaper into this checmical as this person reported very extreme side effects, and I've always wondered if there was any pscyhological strings attatched with ingesting this chemical akin to the dysphoria one might feel after stopping stimulant usage over a prolonged period of time.

[Jeoshua]

Whatever might be true is certainly not going to have to be true to Noopept. Despite common knowledge, Noopept is NOT a racetam. Any studies that show that Noopept does this or that or the other thing will have exactly Zero bearing on the effects or knowledge of what any of the 'Racetams do. Long story short, they're all called nootropics, but Noopept and 'Racetams are very different beasts.

FWIW, I had great experiences with Oxiracetam, my favorite of the 'Racetams, but Noopept didn't do anything but give me a mild anxiolytic effect and a marked increase of the "tip of the tongue" effect.

[Sciencyst]

With noopept, less is definitely more... My first "attack" dose was a few hundred mg over the day (sublingually).. Maybe totalling roughly a gram but I dont have my scale. And I thought it wasnt doing anything. When I take one microscoop of it life is beautiful though. It seems to have some rate limiting enzyme or dose ceiling.