That's a really dumb thing to do unless perhaps you have some very bad health condition that you clearly notice physically and have already tried the evidence backed solutions to no avail only then might it be a good idea to start trying out all kinds of things just to see if they work. Of course this method only works if you have some health condition you can notice yourself if it improves. Painful arthritis is one example, if you have that you could test some things and see if you feel less pain. But me f.ex. I don't have arhtitis and my joints feel great. I could try a bunch of arthritis supplements and drugs and not feel a thing because my joints are already feeling great. I would just be wasting my money.
So basically you have never tried oral gluthatione and from your pedestal of self proclaimed longevity guru and professional reviewer of academic literature you are telling people, including those that do suffer from a medical condition and/or genetic mutation, not to bother to take it because most likely, according to your not up-to-date literature review and knowledge (which misses by the way a 6 months Penn State study, pointed out by Turnbuckle, that reaches opposite conclusions), it is mostly worthless and/or placebo.
You later state that you have tried dozens of supplements in your life but in this case you would not even try oral gluthatione because you do not have any bad health condition to justify trying it. That to me it is both a contradiction and an additional reason to keep my mouth closed if I were you.
You also discount my personal experience as a N=1 sample forgetting that also Turnbuckle, who also - at least - tried oral gluthatione before opening his mouth, stated to experience positive benefits from it. This N=1 sample suddenly becomes N=2 sample just in this forum post and would become N=X sample if you just would take the time to read forum posts such as the ones posted by, for example, Chronic Fatigue Syndrome (ME/CFS) sufferers at http://forums.phoeni...ng.me/index.php and MTHFR genetic mutation sufferers as in my case.
I guess all these people are also imagining their relief from oral gluthatione protocols and should rely instead on the closed minded partial review of academic literature carried out by someone that does not suffer from any particular condition nor has ever bothered trying oral gluthatione himself.
Wasting money in my opinion is to subscribe to a web 1.0 looking website that promises you to share the secrets to live to 120 (and maybe beyond) that you have repeatedly publicized in this post.
I have an open mind too and I never said it couldn't possibly help some people but that still doesn't make it a good idea to just go about spending money on trying out supplements with low evidence of benefit. There are hundreds of other supplements I could try out and see if I notice any benefits but it wouldn't be a smart idea. The point about it likely not having effect on me because I am young and healthy, yes, exactly! There is one of the main reason I don't rely on testing supplements. I have tried dozens of supplements in my life and can only quickly recall two that had noticeable effects on me. One is beta-alanine, which caused tingling, and niacin, which also caused tingling. In case of the beta-alanine the tingling is normal and therefore the tingling sensation gave me a nice confirmation that the beta-alanine product I was taking was good quality and actually contained the stated amount of beta-alanine. The tingling didn't mean it necessarily worked or had positive effects on my health, I cannot detect whether it does therefore I go by what the evidence says. The same with niacin, tingling is a normal side effect of high dose niacin and the fact that I felt tingling meant that the supplement likely contained a good amount of niacin but it didn't say much at all about whether the niacin was beneficial or not, to know that it was best for me to examine the scientific literature, which I of course had done before hand.
I am happy to spend my money on supplements that have a consistent and considerable positive effect on my mental and/or body health no matter what the current theoretical evidence of benefit is. In this case I am extremely happy to have tried reduced gluthatione, which is for me a game changer, and I will be happy to try different oral forms of it including the liposomal and acetyl ones.
I have never suggested to randomly try hundred of supplements but instead to do your own research, especially - if available - at a genetic level, and select a few supplements to try based on one's genetic profile.
For my severe morning anxiety I have initially tried all the supplements listed in the remarkable forum post TREATING ANXIETY SAFELY & EFFECTIVELY posted by ScienceGuy in this website. Unfortunately none of them has helped me as much as those that I found out by myself, not thanks to the traditional medical establishment advise, through a genetic test with 23andme.com and third parties apps.
When your anxiety is relieved, your brain fog disappears, your energy levels drastically increase, you do not feel like intermittently sleeping anymore during daytime and are less intolerant to certain food (intolerance that started in my late thirties) are just some of the beneficial effects that I experience when taking gluthatione orally I would not compare it to your tingling experience. We are mixing apples with oranges here and we are talking about a complete different level of symptoms and benefits.
Having a scientific approach is perfectly reasonable but being open minded and trying supplements based on other people personal experience, especially if they share the same medical condition or genetic mutation, makes perfectly sense to me.
Well that's very stupid to do. Yes you should always listen to your body also, but in most cases that still doesn't tell you much. Using the scientific literature is more appropriate, that's why scientists do that.
I think you should really consider to refrain yourself from labeling eveything you do not agree with or that contradicts your "a priori" conviction as stupid, dumb, not smart etc.
You have done it with the comments made by Turnbuckle before, who is far from stupid, and you keep doing it with my personal experience contribution.
I do not think your educational background or professional experience, that you have promptly publicized along with your "envisionary" website, entitles you to lack of respect towards other contributors to this forum no matter what different area of specialization they have.
Lacking of respect and showing an over-inflated ego does indeed make a fool of oneself.
You should care what your doctor recommends although you should never take his recommendation blindly. Why? Because he knows a lot of stuff you don't. But by listening to them I don't mean blindly following their advice. Listen to them keeping in mind how they were educated and what they do and keep in mind that they don't often care so much about your health. You should always do your own research too if you can, but you clearly don't seem to know how to do that. Yes a lot of doctors don't know much about some important genetic mutations but some of them do. Some doctors are more open minded, don't put them all in the same category.
I have already replied to this point. Here in Australia doctors know nothing about methylation genetic mutations and it can take decades before the medical establishment become familiar with cutting edge research findings, including genetics and nutrigenomics.
I have never suggested a black or white, yes or no approach when it comes to the traditional medical establishment; however when you see that the only solutions proposed are habit forming benzos it is time to do your own research and search for alternative and better solutions.
You are only making a fool out of yourself with all these comments. Make sure you know who you are talking to before making such statements. I don't know why you are so pissed off that I don't agree oral glutathione is a valuable supplement in general. Who cares if the scientific literature evidence doesn't fit your personal experience, whether you're an exception to the rule or are feeling placeby if you feel a clear positive effect from taking it then by all means keep doing it because obviously something is having positive effects on you. I am not telling you to stop taking it, I am telling you to stop making stupid claims based on your personal experience. I have made my points. I am done responding to you.
The only person that is making fool of himself is the one that, possibly driven by an over-inflated ego, bases his conclusions merely on a partial literature review, stick to it trying to minimize recent studies, discount personal experiences available in this and other forums, repeatedly label other contributions as stupid, dumb and so on putting himself on a pedestal of alleged untouchability despite having zero direct personal experience with the oral supplementation of reduced gluthatione nor medical condition or genetic mutation to test its real life (not on paper) efficacy against.
