2 replies to this topic

[magniloquentc0unt]

Hello longecity

I have started a course of Moclobemide, and after the bad experience ive had with fluoxetine, Id like to know if anyone is aware of long term side effects of moclobemide at a neurological level.

[blood]

Moclobemide may be neuroprotective (neurological side effects may be beneficial):

http://www.ncbi.nlm....?report=classic

Chiou et al. have elegantly demonstrated that cells isolated from the rat hippocampus, and treated with the antidepressant moclobemide, may be differentiated in vitro into neural cells exhibiting features to those of serotoninergic neurons. They have also suggested that this process was mediated, in part, through the expression of specific antiapoptotic genes (Bcl-2 and Bcl-XL) and via activation of extracellular-regulated kinase. This work raises the attractive possibility that the use of antidepressants, such as moclobemide, may exert neuroprotective and potentially neurogenerative effects not just in vitro, but also in vivo, through the selected differentiation of stem cells into functional neurons...

... More interesting perhaps... was the finding that treatment of cells with moclobemide at the lower concentration of 50μm increased cell survival, pointing towards the possibility that moclobemide may be in fact exerting neurogenic effects. In addition, these findings corroborate with a report by Li et al. (2004), who have shown that moclobemide upregulated proliferation of hippocampal progenitor cells in chronically stressed mice...

Edited by blood, 11 May 2014 - 03:43 PM.

[magniloquentc0unt]

Thanks, that sounds very interesting in term of regenerating SA neurons. I think either prozac (8months) or MDMA (3-4 times in my life at a distance of months between each other) might have either fried or altered mines.