• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Tianeptine Affect on D2 receptors mRNA

tianeptine d2 receptors d2 receptors mrna d3 receptors

  • Please log in to reply
No replies to this topic

#1 noot_in_the_sky

  • Guest
  • 287 posts
  • 17
  • Location:Mex

Posted 02 August 2014 - 02:54 PM


I found this study and was a bit confuse. It seem that tianeptine increases the responds on D2 and D3 receptors, while also decreasing mRNA expression of D2 receptors.

 

So my question was, does the decrease in mRNA expression something worry about?

 

http://www.ncbi.nlm....ianeptine d2 d3

 

 

Effect of repeated treatment with tianeptine and fluoxetine on central dopamine D(2) /D(3) receptors.

Dziedzicka-Wasylewska M1, Rogoz Z, Skuza G, Dlaboga D, Maj J.
Author information
Abstract
 
Tianeptine (TIA) is an antidepressant drug that has been shown to decrease extracellular serotonin level and reveals no affinity for neurotransmitter receptors. The present study was aimed at determining whether repeated TIA treatment induced any adaptive changes in the central dopamine D(2)/D(3) system (behavioural and biochemical) similar to those reported earlier for tricyclic antidepressants. Experiments were carried out on male Wistar rats. TIA was administered at a dose of 5 and 10 mg/kg once or repeatedly (twice daily for 14 days). Fluoxetine (FLU), used as a reference compound, was also administered at a dose of 10 mg/kg. The results obtained showed that TIA or FLU administered repeatedly increased the hyperlocomotion induced by D-amphetamine and 7-hydroxy-dipropylaminotetralin (7-OH-DPAT). Biochemical study revealed a decrease in the [(3)H]7-OH-DPAT binding sites after acute and repeated treatment with TIA or FLU in the islands of Calleja minor, as well as in the shell part of nucleus accumbens septi. On the other hand, both TIA and FLU administered repeatedly increased the binding of [(3)H]quinpirole (a D(2)/D(3) receptor agonist) in the nucleus caudatus as well as in the core part of the nucleus accumbens septi. Similar effects have been observed when dopamine D(2)/D(3) receptors were visualized with the use of [3H]raclopride, a dopamine D(2)/D(3) receptor antagonist. However, TIA and FLU induced a decrease in the level of mRNA encoding for dopamine D(2) receptors, not only after repeated but also after acute treatment. These results indicate that repeated TIA and FLU administration induces adaptive changes in the dopaminergic D(2)/D(3) system and especially enhances the functional responsiveness of dopamine D(2) and D(3) receptors. However, the question of whether this increased responsiveness is important for clinical antidepressant efficacy remains open.

 


  • WellResearched x 1





Also tagged with one or more of these keywords: tianeptine, d2 receptors, d2 receptors mrna, d3 receptors

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users