JDTic: Pioneering Research into Potent KOR antagonism
Theories Behind KOR Antagonist Treatment and JDTic (as taken from TeamTLR)
JDTic via selective, potent, and long-acting KOR antagonist activity is theorized to alleviate psychoneurodysfunctional [Google it] states (moderate to severe), within a broad range of conditions, including states that encompass depression states, anxiety/fear/trauma states, OCD-S states, addiction states, depersonalization-related states, and other such psychoneurological/emotional states adverse to well-being.
The opioid system is the seat within the balance set within evolutionary 'design' of wellness:unwellness, and most all that is encompassed within such. Within that theory, currently proposed theory denotes the potential of direct antagonist activity upon KOR, the “seat of unwellness”, to foster a potent counter to this opioid receptor that is responsible for 'negative-state' promotion.
Antagonizing the receptor would appear to have no tolerance and addiction potential as with the induction of agonist activity of MOR, the “seat of wellness”, wherein such modalities are not viable as within bearing the intrinsic flaws of rapid tolerance and high addiction potential (among other well-known non-psychoactive adverse effects).
Quite to the contrary, KOR antagonist activity is anti-tolerance and anti-addiction, providing 'resetting' of “emotional tone” primarily through resetting of these pathways; within markedly reversing dysregulation within dopaminergic pathways and other addiction-related/tolerance-related pathways.
“Emotional Tone” or “Psychoneurofunctional Tone” is the level of resistance to adverse/dysfunctional emotional states (psychoneurodysfunctional states, which as well encompasses addiction states). JDTic in in vivo animal research has demonstrated long-acting effects (>30 days) within its KOR antagonist activity, to be such that in which is seen to 'corrupts' the KOR, which appears to be mediated via a c-Jun activation dependent mechanism.
To have capacity to so profoundly improve core(KOR) tone would appear to be of greatest value as a base treatment for improving a plethora of psychoneurodysfunctionalities.
JDTic Research / Experience:
Subject starting JDTic dose at 500MCG per day via sublingual route of administration. Subject has been diagnosed with depression / anxiety and other phobias inherited via a history of family mental illness and through self traits. I will be doing at 500MCG via 0.25ML of alcoholic-based solution @ 40%.
Day 1: T - 10:00AM:
Subject has administered the 0.25ML of solution containing 500MCG worth of JDTic. Subject feels slightly inebriated as to say with a slight increase in “emotional tone”, no VT has been noted thus far. At this point, I feel slightly depressed but have less anxiety levels then when administered.
I dosed another 500MCG, via the same route of administration as before. Subject feels slightly more “happier” and vision seems “HD Like”, with more vividness and colour although light is more sensitive.
Day 2: T – 8:00AM:
Subject will be dosing 1MG through 0.5ML of solution. Subject feels more of an “emotional tone” at this dose although not much of a mood uplift. Subject will be dosing via inhalation tomorrow.
Subject feels down and unsure of this unhappiness. Although, subject has found that when emotional tone is most noticeable the depression of the subject is felt more. This “negative mood” sensation goes with another dose subject took T+1:00 after initial dose.
Subject doses another 1MG of JDTic, achieving a good mood uplift with the enhanced emotional tone / state.
Day 3: T – 8:23AM:
Subject took 1MG through administering 0.5ML of solution via inhalation from a syringe (without needle). Subject feels the effects are felt quicker through administering the JDTic via inhalation.
Subject feels a nootropic form of action occurring as subject experiences increased visual clarity and sudden rapid mood uplifting effects. Subject feels more aware of his environmental stimulus with increased visual saturation.
Day 4: - 12:04PM:
Thus far, subject has not noticed any form of VT that has occurred from the administration from JDTic. At day four, the “emotional tone” from the JDTic is more pronounced. This tone gets more noticeable as the days go by.Today, subject will be administrating 2MG worth of JDTic via 2ML of solution SubL.
T + 3 Minutes – Subject feels a “lightness” come over him with a sensation of being inebriated.
T+ 6 Minutes – Subject feels “happy” and “emotionally uplifted”, as if the world has more meaning embedded into it. Life’s events appear to be funnier, social conversations appear to be more interesting and enjoyable.
Day 10: - 3:00PM:
After a 10 day period of dosing with JDTic at 1MG (despite the 2MG during day 4 for “testing purposes”, subject feels that mainly his “fear”, “social phobias” and “anxieties” have faded over this period of time.
Subject feels that JDTic is a drug that you have to administer over a graduated amount of time in order to see any “real” benefit from it. My mood has also uplifted a lot, although subject feels like his fear has mostly been diminished the most from this 10 day administration of JDTic.
Subject at this current moment in time feels less hostility, more loving and caring towards people and general love for the things in his life and those around him.
Subject feels it is not rewarding in itself, but life seems richer and the days more infused with meaning. JDTic is most effective at preventing stress and fear. JDTic is definitely a drug worth investigating IMO. Although, recommended administration would be via inhalation / nasal spray over at least a month to get true KOR-antagonism. 
