Just wondering where would we begin if we were looking to reverse the damage caused by antipsychotics in relation to the various movement disorders that result from them? I am referring to the various muscular dystonias generated by prolonged use of various atypical antipsychotics and I am looking for substances of interest which would contribute to the reconstruction of the brain in the affected regions and otherwise.
The most compelling line of evidence suggests that tardive dyskinesia may result primarily from neuroleptic-induced dopamine supersensitivity in the nigrostriatal pathway, with the D2 dopamine receptor being most affected. Neuroleptics act primarily on this dopamine system, and older neuroleptics, which have greater affinity for the D2 binding site, are associated with high risk for tardive dyskinesia.[13] The D2 hypersensitivity hypothesis is also supported by evidence of a dose-response relationship, withdrawal effects, studies on D2 agonists and antagonists, animal studies, and genetic polymorphism research
http://en.wikipedia....dive_dyskinesia
A few targets have been identified already - melatonin, antioxidants and vitamins, here's a good link referring to treatment via melatonin and it turns out that higher doses of it work quite well in reaching the necessary parts of the brain.
It would be pertinent to identify how antipsychotics cause damage and to what parts of the brain and in which ways they do so, in order to develop a dependable framework for identifying treatment targets. I guess if we can understand the mechanism fully then there are probably a fair number of plants and other things already floating around which restore function & structure to the intended places. If you are experienced or well-versed in the relevant science behind this matter, your input would be supremely appreciated.
